Sentences with phrase «labs studying genes»

Members of our lab study gene expression and organelle function in plants and humans.

My lab studies genes and signals in cells that regulate the growth and shape of plants.

The lab studies gene regulation via multiple lines.

Not exact matches

This study built on previous research from the Sundrud lab, which showed that when TH17 cells entered the intestine in human tissue samples, they increased the expression of a gene called MDR1.

Michael Kaplitt, a neurosurgeon at Weill Cornell Medical College in New York, whose lab develops gene therapies for brain disorders, teamed up with Greengard and other colleagues in the new study.

Europe came through: Last year, Cory received a European Molecular Biology Organization (EMBO) Installation Grant for his lab in mitochondrial biogenesis, and Gülayşe won a Marie Curie International Reintegration Grant from the European Commission to study how single genes can yield different protein products in neurons.

The researchers determined that CRISPR had successfully corrected a gene that causes blindness, but Kellie Schaefer, a PhD student in the lab of Vinit Mahajan, MD, PhD, associate professor of ophthalmology at Stanford University, and co-author of the study, found that the genomes of two independent gene therapy recipients had sustained more than 1,500 single - nucleotide mutations and more than 100 larger deletions and insertions.

The only trouble was that the Nasmyth lab was devoted entirely to the study of the HO gene (involved in mating - type switching) in the budding yeast Saccharomyces cerevisiae.

Bloch's colleagues at the National Institute of Environmental Health Sciences tested the oils in gene expression studies on lab - grown human breast cancer cells and found that they could mimic estrogens, the primary female sex hormones, and inhibit androgens, the primary male sex hormones.

So far, researchers have mostly turned on genes with CRISPRa in cells growing in lab dishes, says Charles Gersbach, a biomedical engineer at Duke University not involved in the new study.

To find out, the team looked at several hundred human mu opiate genes, lumping together their own studies of several dozen volunteers from pain or opiate addiction clinics with studies from other labs.

But he wanted the convention to call for greater transparency in how the technology is studied in labs and deployed in the field, for instance by creating a mandatory gene - drive registry.

Perhaps most significantly, in a study led by Frances Champagne — then a graduate student in Meaney's lab, now an associate professor with her own lab at Columbia University in New York — they found that inattentive mothering in rodents causes methylation of the genes for estrogen receptors in the brain.

«I'm not used to that kind of conference,» says Messer, who says he told the group about his lab's efforts to study the evolution of resistance to CRISPR gene drives in fruit flies.

A recent study was the first to show that a particular gene affects financial behavior outside the lab

In 2002 a student in Christiano's lab was studying the Human Genome Project database and noticed an unnamed region where Christiano had predicted the human version of the lanceolate gene would reside.

Both studies relied on a popular lab organism known as C. elegans, a nearly microscopic nematode that is fast growing, translucent and has a sequenced genome showing that nearly half its genes are closely related to corresponding human genes.

«Nevertheless, this gene will be useful in combination with other STB resistance genes, and our study provides tools for rapid lab - based tracing of Stb6 in wheat breeding lines,» says Kanyuka.

When that lab closed she went back to university, working in a biochemistry and molecular biology lab to study gene expression during wine making, but this contract, too, came to an end.

Prior studies from the Sancar lab showed that excision repair works more efficiently for actively transcribed genes in animals and bacteria.

Studying how genes affect different drugs manufactured by different companies gives Poirier greater influence on future drug development, he feels, which would not be possible if he was employed at any one pharmaceutical research lab.

The experiments set off a debate about the safest way to do gene drive experiments in the lab and helped prompt the Defense Advanced Research Projects Agency and the Bill & Melinda Gates Foundation to support the academies's study.

Geneticist Jiří Forejt of the Czech Academy of Sciences» Institute of Molecular Genetics in Prague wasn't looking for it when he caught wild mice and bred them with lab mice to study diversity of immune system genes.

To begin to grapple with those questions, the researchers involved in the new study first selected as «seeds» the nine genes that have been most strongly tied to ASDs in recent sequencing research from their labs and others.

Working with Berkeley Lab scientist Jill Banfield, a study co-author and also a professor in UC Berkeley's Department of Earth and Planetary Sciences, the team used newly developed DNA - based methods to identify all of the genomes of the microbes that used the introduced oil for growth along with their specific genes that were responsible for oil degradation.

The researchers in the Greenberg lab found that across all analyzed datasets, and in studies of different mouse brain regions, in the absence of MECP2 the expression of long genes is increased.

Those tests will answer basic questions about changes in cells and genes; they are not the elaborate, years - long studies exposing lab animals or examining humans that can answer most important health questions.

However, animals that had mutations with Pcdha9, but not Sap130, can display defects in the aorta, but with normal - sized left ventricles, suggesting interaction between the two genes is needed to cause all the features of HLHS,» said Xiaoqin Liu, M.D., Ph.D., the first author of the new study and a research instructor in Lo's lab.

Combining fossils and lab studies, researchers home in on genes that transformed a snout into a bill

Geneticists usually prefer to study genes that are easy to mutate so that work can be replicated or varied, but only one lin - 4 mutation had ever been observed, in Brenner's Cambridge lab a few years earlier.

But a recent study was the first to show that a particular gene affects financial behavior outside the lab.

Kuruvilla's lab group — which has been studying the peripheral nervous system for years — found that abundance of a particular gene product in Down syndrome puts a brake on NGF's actions in fostering nerve development.

«We found the IFG2 gene marks the beginning of reprogramming to hematopoietic cells,» said Dr. Masatoshi Nishizawa, a hematologist in the Yoshida lab and first author of the new study.

According to Saura, «this study opens up new perspectives on therapeutic prevention and treatment of Alzheimer's disease, given that we have demonstrated that a gene therapy which activates the Crtc1 protein is effective in preventing the loss of memory in lab mice».

«When I first started doing plant paternity studies in the 1980s,» Ellstrand comments, «our lab assumed that gene flow was limited.

Previous evidence for a breast cancer link has been mixed — one study found increased risk in women exposed before age 14, whereas others found no association — but in a lab dish, DDT has been shown to activate the HER2 gene in human breast cells, which is expressed in some breast cancers.

Previous studies have revealed that human hair, reptile scales and bird feathers evolved from a single ancestor — a reptile that lived 300 million years ago — but this new study from the Fraser Lab at Sheffield has found that the skin teeth found on sharks also developed from the same genes.

Instead, researchers will have to rely on other evidence that the mutations are harmful, such as lab studies of the proteins encoded by the genes.

«We may have discovered a major step toward developing a «dream tool» for remotely controlling neural circuits, by manipulating specific cells using engineered gene products that respond to magnets,» said Ali Deniz Güler, a UVA biology professor who led the study in his neuroscience lab.

In a study published January in the journal Molecular Biology and Evolution, Gibbs and his team compared the DNA of the fat fruit flies to a control group in the lab and found nearly 400 candidate genes potentially associated with obesity and other health problems.

Terry Hwa's lab has been working on quantitative descriptions of how genes, proteins and chemicals work together to coordinate the physiological responses of the gut bacterium E. coli, and is more recently studying the interaction of gut microbes with each other and with the host environments.

These fruit flies in a lab at UNLV are good models for studying how genes affect human obesity.

1) Co-authors of the gata5 study, published in Genes & Development, were lead author Jeremy Reiter, and Jonathan Alexander, both MD / PhD students funded by the NIH Medical Scientific Training Program and students in Stainier's lab, Deborah Yelon, PhD, a postdoctoral fellow in Stainier's lab, Adam Rodaway, PhD, and Roger Patient, PhD, both of Developmental Biology Research Centre, The Randall Institute, King's College London, and the late Nigel Holder, PhD, of the Department of Anatomy and Developmental Biology, University College London.

In other work, the lab is exploring the mechanisms of heterochromatin formation and gene silencing through the study of a protein complex called RNA - induced initiation of transcriptional gene silencing (RITS).

In studying the regulation of gene dosage, his lab described the first known biological role of a microRNA in the mammalian system, ultimately revealing a network of microRNAs that titrate the dose of key cardiac gene networks that dictate cell fate and differentiation.

Only introducing the altered gene into cells and studying protein function in the lab provides that information, Traynelis says.

Previous studies from many labs, including a group at Cambridge University, showed that when exposed to the primary female sex hormone, estradiol, the estrogen receptor activates genes that encourage tumor cells to grow and divide.

Marek is performing postdoctoral research in the lab of Nick Ingolia at UC Berkeley studying the regulation of gene expression.

Her lab is using stem cells to study the function of the disease - causing gene and to generate human neurons suitable for transplantation and pharmacological screening.

Stephane completed his PhD at Cold Spring Harbor Laboratory studying RNA interference mediated gene regulation in Robert Martienssen's Lab.