«What we saw in mice
lacking STIM1 — whose T - cells can not generate
calcium signals — is that the number of mycobacteria in their lungs was dramatically increased, resulting in excessive inflammation,» says Stefan Feske, MD, an associate professor of pathology at NYU Langone and the study's senior author.
The mice also scratched if they
lacked the
calcium channel that transmits chloroquine - induced itch
signals and were exposed to chloroquine.