Sentences with phrase «lack of activation»

A stubborn muscle group is often a result of the lack of activation of the CNS, thus using an unstable exercise could fix the problem.

Over time, this lack of activation leads to muscle imbalance and instability.

This lack of activation occurs because C - RAF lacks a constitutive charge within a motif in the kinase domain called the N - region.

Not exact matches

Their work elucidates a dynamic, two - step mechanism in females whereby B cells lacking the markers of X chromosome inactivation regain these modifications during B cell activation, in a process involving the transcription factor YY1.

In addition to looking for potential drugs and drug targets to control infection, the group is also addressing a major hurdle in controlling TB, which is the lack of accurate biomarkers that can predict granuloma activation.

Thus, the sustained activation which is necessary for a transformation of cells into cancer cells is lacking.

Existing electrode based ACC stimulation lacks specificity and leads to activation of both excitatory and inhibitory neurons.

MUS81 plays an essential role in this killing of cancer cells because nuclear DNA was not cut in cancer cells that lacked the enzyme and no activation of the immune system was observed in these cells.

Alison Murdoch of the Newcastle center noted that crucial knowledge is still lacking on what constitutes a «good» egg, on «what is the appropriate activation signal» for the oocyte, and on how long nuclear reprogramming takes.

On the flipside, they found mTORC1 activation defective in cells engineered to lack expression of SLC38A9.

The lack of cysteine proteinase inhibitor stefin B influence inflammasome activation and cytokine secretion

Bradley MN, Hong C, Chen M, Joseph SB, Wilpitz DC, Wang X, Lusis AJ, Collins A, Hseuh WA, Collins JL, Tangirala RK, Tontonoz P. Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.

In addition, a homolog of PHYB ACTIVATION - TAGGED SUPPRESSOR1 (BAS1), which encodes an enzyme that inactivates BRs (Neff et al., 1999), was also significantly reduced in the mutant, suggesting that inactivation was also decreased in response to a lack of BRs.

Diminished contact - dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D.

The new studies identify activation of endothelial Toll - like receptor 4 by Gram - negative bacteria as a critical event in formation of cerebral cavernous malformations, a significant predisposing condition for stroke and seizure for which effective medical therapies are lacking.

The contrast between the effects of these transfers on immunity and lack of immune activation by wAu transferred to D. melanogaster could be explained in various ways.

Failure of rTMS to increase BG activation in dystonia may be associated with the lack of effect on sensory discrimination in this group and may reflect impaired processing in BG - S1 connections.

Sub-second oscillations of inositol 1,4,5 - trisphosphate and inositol 1,3,4,5 - tetrakisphosphate during platelet activation by ADP and thrombin: lack of correlation with calcium kinetics

T - DOGGs can be made drug - inducible using the rTetR system, but Cre - DOG lacks the toxicity that can be seen with high levels of transcription activation domains.

In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10

Because the STAT6 DN form lacks the 662 — 847 aa, it is therefore devoid of the major portion of the transcriptional activation domain, and hence acts negatively.

In our laboratory, we have previously described an in vitro model of spontaneous transformation of the IL -3-dependent hematopoietic BaF3 cell line towards growth factor - independent tumorigenic clones with constitutive STAT5 activation.14 This model was developed from the study of BaF3 cells transfected with an IL - 9Rα mutant lacking the STAT - recruiting site (BaF3 phe116).

Experiments in mice lacking CTLA - 4 and use of CTLA - 4 antibodies demonstrated that absence of CTLA - 4 or blocking its activity could lead to T cell activation and tumor destruction.

In other words, lat pull - ins can make up for what other traditional back movements lack in terms of lat activation, more specifically rowing movements and lat pull - downs and pull - ups, because they allow you to stretch and contract your lats in a far superior way.

«The primary problem with the traditional plank is the lack of deep core activation over an extended period of time,» according to John Rusin, a physical therapist and strength coach.

Inflammation is the chronic activation of our immune system caused by eating a high carb, high processed food diet, lack of proper nutrients, chemicals in our environment, the overuse of medications, and, high levels of stress.

Sitting is not only bad for your health in general but it also creates acute problems such as back pain, lack of glute muscle activation, reduced circulation, and stiffness in the hip joint.

The liver can not utilize ketone bodies because it lacks the mitochondrial enzyme succinyl CoA: 3 - ketoacid CoA transferase required for activation of acetoacetate to acetoacetyl CoA [3].

Lack of core activation and full - body tightness, particularly during upper body pressing exercises, is a common training mistake.

If you feel like you're about to flip off the bench using a 70 - pound dumbbell but you typically handle 100 - pounds in each hand, then you're probably lacking significant levels of core activation, rotary stability, and full - body tightness.

Conclusion «The lack of significant differences in muscle activation between stable and unstable bench press may allow use of unstable loads by practitioners to add variety to resistance training programs», the researchers concluded.

Given that a lack of gluteus maximus involvement has also been implicated in several musculoskeletal conditions, this has led many clinicians to use isolated «glute activation» training, in order to help encourage the glutes to work harder during multi-joint exercises.

Allowing an end - user to set their own wireless enterprise activation password is literally a godsend in most situations, although the lack of an open management interface to this particular module somewhat disappoints me, although that's technically not what this product was designed for, either.

The FTC charged Telomerase Activation Sciences, Inc. and Noel Patton (collectively, TA Sciences) with lacking the scientific evidence to support claims that their capsules, powders, and creams could provide a broad range of anti-aging and other health benefits.

Finding a direct connection between network congestion and price is not a straightforward task, so it's not entirely clear whether miners are profiting directly from the lack of Segregated Witness (SegWit) activation or a hard - forking increase in the block size limit.

But, the majority of the Bitcoin community opposed the activation of SegWit2x, due to the lack of support from Bitcoin Core developers and users.

Interpersonal trauma, lack of stress - reducing secure attachment, and chronic activation of fear, often results in posttraumatic stress disorder (PTSD) in children.

First, the lack of hormonal and psychophysiological data limits our inferences about how attachment activation may impact on the stress response system.