Sentences with phrase «lack of development activity»

The office sector is still far from being considered «healthy,» as evidenced by the lack of development activity.

Not exact matches

The report further cites a «lack of faculty support» for professional development activities at many institutions.

Although we agree that greater investments are needed in the clinical development of these therapies, we disagree with the authors» suggestion that, relative to embryonic stem cells, adult stem cells provide a superior vehicle for cell - based therapies because they lack tumorigenic activity, can be prepared by methods approved by the Food and Drug Administration (FDA), and have been free of ethical controversy.

In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10

Family history, age, gender, smoking, diabetes, high blood pressure, and lack of physical activity all influence, perhaps not equally, the development of heart disease.

Inadequate detoxification of toxins through lack of well - supported and well - regulated Phase I and Phase II detox activity has clearly been shown to increase risk of cancer development.

Issues in rural schools can include fewer resources for students and teachers; lack of access to professional development and student training opportunities; community isolation; students having the same teachers for multiple subjects and grade levels; and fewer extracurricular activities.

NUT Cymru secretary David Evans added that there were «significant barriers» to promoting better collaboration between schools or better access to professional development «from a lack of high quality training provision, a lack of financial resources to release teachers or workload pressures making non-classroom activity almost impossible».

The topic of sexism in game development has been a big issue recently, especially since for a long while, video games was often viewed as a «boys only» activity, but Tomb Raider scriptwriter, Rhianna Pratchett believes that it may not be the sole reason for the lack of female game...

The report highlights broad exemptions granted to industry from prohibitions, major delays in the development of recovery strategies for at - risk species, and a complete lack of public transparency about harmful activities occurring in at - risk species» habitats.

After years of the British government suffering criticism from international organisations such as the Organisation for Economic Co-operation and Development and Transparency International for its lack of enforcement activity in the area of overseas bribery, it appears that a real and tangible momentum is gathering pace behind the new Bribery Bill.

Several modifiable risk or protective factors have been identified, such as infant feeding mode (bottle vs breastfeeding), parental responsiveness to infant feeding cues and infant distress, the age of bottle weaning, timing of the introduction of solid food, sweetened beverage consumption and lack of physical activity.84 — 88 Inactivity can delay motor development and further increases the risk for early childhood obesity.85 89 — 91

In early childhood development, attachment is so important that a lack of connection to a secure attachment figure (most likely the mother, father, or other major caregiver) who was reliable and available results in physical alterations to the anatomy and chemistry of the brain, such as reduced brain activity and less developed cortexes.

The likelihood of self - initiated economic development activity seems remote given that NTRBs currently claim lack of authority and capacity to do the same.