Sentences with phrase «lack of dystrophin»

Duchenne Muscular Dystrophy (DMD) is coaused by a lack of dystrophin which is expressed in muscle fibers where it plays a role in ensuring structural integrity.

Manipulating proteins in the body to compensate for the lack of dystrophin is one of many strategies being investigated to halt or reverse the muscle damage caused by DMD.

Their study published online ahead of print in PNAS Early Edition suggests a new therapeutic strategy for patients with Duchene muscular dystrophy, a progressive neuromuscular condition, caused by a lack of dystrophin, that usually leaves patients unable to walk on their own by age 10 - 15.

Lack of dystrophin makes the muscle cell plasma membrane more vulnerable to injury.

The inherited condition, most common in boys, results from a lack of dystrophin, a protein that's essential for healthy muscles.

Not exact matches

This balance can be disrupted in diseases such as Duchenne muscular dystrophy, which is caused by the lack of a muscle - specific protein, dystrophin.

Lead investigators David Burns and Ken O'Halloran at University College Cork, in conjunction with collaborator labs at the University of Calgary and Trinity College Dublin, performed experiments in mice lacking dystrophin, the muscle protein that malfunctions in DMD.

Campbell and his colleagues began their work by genetically engineering knockout mice that lacked a functioning protein called δ - sarcoglycan, which is part of a larger molecular assemblage called the dystrophin - glycoprotein complex (DGC).