Sentences with phrase «lack of efficacy of»

Are There Factors Other Than Lack of Efficacy of Monthly Heartworm Preventatives That Could Explain The Increase In Heartworm Cases?

I find the Free T3 and Reverse T3 to be invaluable in understanding the lack of efficacy of T4 in some patients.

Lack of efficacy of thickened feeding as treatment for gastroesophageal reflux.

Not exact matches

Topics included: early reporting on inaccuracies in the articles of The New York Times's Judith Miller that built support for the invasion of Iraq; the media campaign to destroy UN chief Kofi Annan and undermine confidence in multilateral solutions; revelations by George Bush's biographer that as far back as 1999 then - presidential candidate Bush already spoke of wanting to invade Iraq; the real reason Bush was grounded during his National Guard days — as recounted by the widow of the pilot who replaced him; an article published throughout the world that highlighted the West's lack of resolve to seriously pursue the genocidal fugitive Bosnian Serb leader Radovan Karadzic, responsible for the largest number of European civilian deaths since World War II; several investigations of allegations by former members concerning the practices of Scientology; corruption in the leadership of the nation's largest police union; a well - connected humanitarian relief organization operating as a cover for unauthorized US covert intervention abroad; detailed evidence that a powerful congressional critic of Bill Clinton and Al Gore for financial irregularities and personal improprieties had his own track record of far more serious transgressions; a look at the practices and values of top Democratic operative and the clients they represent when out of power in Washington; the murky international interests that fueled both George W. Bush's and Hillary Clinton's presidential campaigns; the efficacy of various proposed solutions to the failed war on drugs; the poor - quality televised news program for teens (with lots of advertising) that has quietly seeped into many of America's public schools; an early exploration of deceptive practices by the credit card industry; a study of ecosystem destruction in Irian Jaya, one of the world's last substantial rain forests.

The Dukan diet and the Whole30 diet, which the experts labeled as lacking scientific evidence of efficacy and as being entirely too restrictive to be healthy.

Not only should clinicians consider the lack of evidence supporting the efficacy of rACTH, but its story should cause us to reexamine and strengthen our standards for FDA approval, Medicare and private insurance coverage, and professional use patterns.»

Last year, the FDA approved a pioneering Duchenne treatment from Sarepta Therapeutics (srpt) over the protests of its own scientific advisers who said it lacked proven efficacy.

One might question the efficacy of having a variety of regulatory frameworks where a company may meet one state's regulation but be unable to meet another's due to a lack of legislative synonymy.

«What is not clear to us is whether the low yield of eggs was the culprit in the lack of a robust efficacy signal» in the Phase 1 study, he explained.

The limitations of macroprudential policies reflect the potential for risks to emerge outside sectors subject to regulation, the potential for supervision and regulation to miss emerging risks, the uncertain efficacy of new macroprudential tools such as a countercyclical capital buffer, and the potential for such policy steps to be delayed or to lack public support.14 Given such limitations, adjustments in monetary policy may, at times, be needed to curb risks to financial stability.15

Vastly more important than its lack of efficacy, however, would be its unfaithfulness to Christ.

He says: «As a result of the extended period of time that can elapse between meetings, and the nature of confessing something that is embarrassing, these kinds of groups often dissolve because of a lack of efficacy.

Whereas other baby washes often either lack scent or have a faint scent, there is no doubt about the efficacy and pleasantries of the lavender aroma produced by washing with this product from Little Twig.

In the third trial of the nurse home visitor program, nurse - visited, 6 - month - old infants born to mothers with low psychological resources (i.e., maternal IQ, mental health, and sense of efficacy) displayed fewer aberrant emotional expressions (e.g., low levels of affect and lack of social referencing of mother) associated with child maltreatment.18

7 They can also make mothers who experience breastfeeding difficulties feel that there is little they can do to change the situation because of their perceived lack of self - efficacy.

Bill Hammond notes the governor signed the mammography bill «despite a lack of evidence about the long - term efficacy of the procedure.»

It also teaches the «Maharishi Vedic Approach to Health», a system of herbal medicine, most of which lacks evidence of efficacy and safety.

It is worth noting at this point that this is not yet another case of a drug entering the market only to be withdrawn later because of lack of efficacy or even adverse reactions which could have been noticed with longer or larger trials.

Twelve percent withdrew from the study for lack of efficacy.

Despite a lack of rigorous clinical trials to test safety or efficacy, a ban of the treatment by health authorities, and a lack of peer review by the scientific community, the privately funded Stamina Foundation has been using cultured mesenchymal stem cells that have been exposed to putative conditions that favour neuronal differentiation to treat different diseases in severely or terminally ill patients.

There is no evidence that patients have suffered harm from these drugs; the FDA says it has detected no increase in reports of side effects or lack of efficacy among Cetero - tested medications.

Intervention from wealthy non-scientists such as the philanthropist Mary Lasker drove even deeper investment into animal - based vaccines despite growing evidence of their lack of safety and efficacy.

The technology has led to few approved drugs owing to safety problems and a lack of efficacy.

Given the lack of evidence to support the efficacy of antidepressants in bereavement, physicians should take a conservative approach in prescribing to avoid overtreatment.»

While buprenorphine has long been used to treat adults with opioid dependence, its efficacy can be hindered by lack of adherence to daily, sublingual (beneath the tongue) doses of the medication.

Conventional drug discovery remains a hit - and - miss affair and Hunter believes the 50 percent failure rates seen for experimental compounds in mid - and late - stage clinical trials due to lack of efficacy is unsustainable, forcing a shift to AI.

«Additional studies should certainly be considered, but we hope that medical professionals will consider the positive potential of honey as a treatment given the lack of proven efficacy, expense and potential for adverse effects associated with the use of DM,» said lead study author Ian Paul, a pediatrician and associate professor of pediatrics.

Marcus and Grollman disagree with the World Health Organization's endorsement of the use of traditional herbal remedies on the premise that traditional medicine is of proven quality, without mentioning the lack of scientific evidence supporting the efficacy of herbal remedies or their demonstrated hazards, as in the case of Aristolochia.

«Despite the increased quality risks and the lack of safety and efficacy data for non-FDA regulated custom - compounded bioidentical hormones, their use by menopausal women is higher than expected and appears to be continuing to grow,» said lead researcher JoAnn Pinkerton, MD, a professor of obstetrics and gynecology at the University of Virginia Health System, Charlottesville.

On «the lack of quality controls on cells,» which makes the treatment hard to replicate, thus not guaranteeing safety and efficacy of the product

The researchers found that military sexual assault training is often lacking in content and efficacy, especially in the eyes of personnel for whom it is most relevant.

Three patients discontinued, two with genetically undefined conditions due to lack of efficacy, and one CANDLE patient due to BK viremia and azotemia.

Medical professional societies and clinical researchers advocated for the policy based on the available literature on FMT's safety and efficacy and the lack of treatment alternatives for this patient population.

«Using proteins that are found on the surface of bacterial cells as the basis for vaccination may lack efficacy because of the variability of the exact protein structure,» says Mobley.

There is evidence that rTMS is safe and not associated with any adverse events, but given the variability in technique and outcome reporting that prevented meta - analysis, the evidence for efficacy of rTMS for seizure reduction is still lacking despite reasonable evidence that it is effective at reducing epileptiform discharges.

One of the limitations of preclinical efficacy evaluation is the lack of appropriate animal models covering important aspects of the human disease.

Structured Abstract Introduction: The analysis of pharmaceutical industry data indicates that the major reason for drug candidates failing in late stage clinical development is lack of efficacy, with a high proportion of these due to erroneous hypotheses about target to disease linkage.

Clearly this is a testament to the effectiveness of advertising to physicians and the general public as our most well respected scientific journals support its lack of efficacy.

«We conclude that there is a lack of efficacy in mild Alzheimer's,» says the lead researcher, Lon Schneider, M.D., a professor of psychiatry, neurology, and gerontology at the University of Southern California, in Los Angeles.

Another 2015 review cites «inconsistent / weak evidence» for flossing and a «lack of efficacy.»

With direct proof of serotonin deficiency in any mental disorder lacking, the claimed efficacy of SSRIs is often cited as indirect support for the serotonin hypothesis... The fact that aspirin cures headaches does not prove that headaches are due to low levels of aspirin in the brain.

Persistent hunger and irritability noted in non-obese men and women in earlier IER trials, where food was completely restricted on alternate days, suggest that some individuals are unlikely to be able to comply for extended periods of time.33 Compliance with IER protocols which allow some intake on restricted days have been promisingly high.38, 43, 48, 49, 51, 52 Additionally, several studies have also demonstrated a lack of compensatory hyperphagia 38, 39, 41, 48, 52, 84 upon resumption of free - eating which, if were to occur, would be expected to limit the efficacy of IER as a weight loss / maintenance strategy.

Conventional medicine offers medication to its sufferers that is designed to slow the pace of cognitive decline but seems to lack efficacy.

Conventional medicine offers medication that is designed to slow the pace of cognitive decline but seems to lack efficacy.

The additional two human studies were split, with one of them supporting cooling, while another lacked statistical significance to show icing's efficacy.

Beyond efficacy, safety data are critical for the therapeutic application of fasting but are sorely lacking.

«There is a general lack of self - efficacy or feeling that you have power over the events in your own life, and living in a world where the media and policymakers are focusing on everybody else's stories except those of your community.»

Overcoming the deficit of «efficacy literacy» will not happen overnight, especially given the shocking lack of attention paid to national evidence standards (as shown by Kane's exhaustive study of school minutes).

But then one would recall that other public functions exist, such as health, transportation, and higher education, that make large and urgent claims on the budgets of state governments; that problems other than a lack of money afflict the schools, such as students who arrive unprepared for learning or life in a classroom; and that evidence for the efficacy of money per se is at best mixed.

When it comes to learning and evaluating foreign language skills, eLearning has made it easier and more effective but the lack of proper eTesting has limited its efficacy.