Sentences with phrase «lacked synaptotagmin»
Südhof used genetic engineering to «knock - out» the synaptotagmin gene in mice, with the result that synapses from the forebrains of mice that lacked synaptotagmin lost their capacity for fast calcium - triggered release of neurotransmitter, thus confirming the importance of synaptotagmin in vivo.
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In 1994, he generated mice that lack operational synaptotagmin.