Here, I show that overexpression of follistatin can also cause substantial muscle growth in mice
lacking myostatin, demonstrating that other TGF - ß related ligands normally cooperate with myostatin to suppress muscle growth and that the capacity for enhancing muscle growth by targeting this signaling pathway is much larger than previously appreciated.
By combining the follistatin transgene with a myostatin null mutation, I have been able to generate mice with quadrupled muscle mass, which represents yet another doubling of muscle mass compared to mice only
lacking myostatin.
Not exact matches
However, after the primary testing, going from two to three days after the exercise, satellite cells and
myostatin molecules had come back to their normal numbers in the higher - protein groups, they were
lacking in quantity in the lower - protein group for far longer.
People and animals who have great aesthetics
lack GDF - 8, which has the role of creating
myostatin.