Mice
lacking osteocalcin also had an excess of luteinizing hormone (LH), a pituitary hormone responsible for increasing testosterone production.
In 2013, a team led by Gerard Karsenty, the Paul A. Marks Professor and chair of the department of genetics and development at Columbia University Medical Center, showed that mice
lacking osteocalcin have major cognitive defects.
Not exact matches
To find out how, he turned to an engineered strain of mice
lacking a gene for what was then a mysterious protein called
osteocalcin, which is produced by osteoblasts.