Along with the growing of grains came the domestication of certain animals for use as food, mainly cattle, sheep / goats, pigs and chickens, introducing new foods made from milk into our diets, and subsequently the retention of
the lactase gene into adulthood in cattle - raising populations.
To supply lactase over the long haul, Matthew During and his colleagues at Jefferson Medical College in Philadelphia devised a strategy for incorporating the bacterial
lactase gene into intestinal cells.
Not exact matches
After just a single dose, rat intestinal cells pumped out bacterial
lactase for up to 6 months — showing that the gut cells had inserted the
gene into their DNA and were using it to manufacture the enzyme.
In several groups of people, a
gene variant allowing the
lactase, the enzyme breaking down the sugar in milk, to persist
into adulthood became common about 5000 to 7000 years ago, when humans were herding cattle — as evidenced by this rock painting of domestic cattle in the Jebel Acacus region of the Sahara desert in Libya.
As children get older, the
lactase gene is gradually disabled, which means that no
lactase is formed and the lactose enters the colon undigested, where it is typically converted
into acids and hydrogen gas and, in many people, causes the painful symptoms of lactose intolerance.
Babies and young children can digest mama's milk because they have an active LCT
gene that produces
lactase in the intestines, a protease that breaks down the lactose protein
into more simple sugars as it moves through the digestive system.