Sentences with word «lamellipodia»

The researchers found that p53 limits invasion by initiating a chain of events that ultimately prevents the formation of lamellipodia, cell membrane protrusions that spur cell movement and invasion.

With low levels of active p130Cas, cells don't form lamellipodia and are therefore less able to invade.

«The targeted nanorods tied up the integrin and blocked its functions, so it could not keep guiding the cytoskeleton to overproduce lamellipodia and filopodia,» said Yan Tang, a postdoctoral assistant in computational biology who worked on the study.

The cytoskeletons also form bristly protrusions called filopodia, which extend out from a weave of fibers called lamellipodia that are on the cell's fringes.

«The light was not absorbed by the cells, but the gold nanorods absorbed it, and as a result, they heated up and partially melted cancer cells they are connected with, mangling lamellipodia and filopodia,» Ali said.

It has been previously shown that hemocytes expressing dominant - negative RacN17 fail to undergo their normal developmental migrations and exhibit stunted lamellipodia formation [29], [30].

ARP2 / 3 - mediated junction - associated lamellipodia control VE - cadherin - based cell junction dynamics and maintain monolayer integrity.

Omi cleaves actin filaments in the cytoskeleton, and the decrease in actin suppresses the activity of p130Cas, a focal adhesion signaling protein that promotes the formation of lamellipodia.

Analysis of the cytoskeletal rearrangements taking place in spreading cells reveals the extension of both filopodia and lamellipodia in response to NG2 engagement (Figure 1).

«All these lamellipodia and filopodia give the cancer cells legs,» said Yue Wu, a graduate student in bioanalytical chemistry.

Photoactivation experiments indicate that microvillar actin is mobilized at the lamellipodium, allowing optimal migration.

It requires cell migration, which is driven by the polymerisation of actin within two distinct structures, lamellipodia and filopodia, and attachment to the extracellular matrix through actin - rich adhesive structures.

Cells initiate migration by extending membrane protrusions, lamellipodia and filopodia, that are driven by actin polymerization.

We show that formation of invadopodia requires only the actin cytoskeleton and filopodia - and lamellipodia - associated proteins.

During migration, cells overcome this problem either by creating a dense array of short - branched filaments as found in lamellipodia, or by bundling filaments as found in filopodia.