Not exact matches
In collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related
proteins such as Ras, nuclear
lamins and insulin - like growth factor receptors.
We demonstrated the technique on 20 different biological processes spanning four orders of magnitude in space and time, including the binding kinetics of single Sox2 transcription factor molecules, 3D superresolution photoactivated localization microscopy of nuclear
lamins, dynamic organelle rearrangements and 3D tracking of microtubule plus ends during mitosis, neutrophil motility in a collagen mesh, and subcellular
protein localization and dynamics during embryogenesis in Caenorhabditis elegans and Drosophila melanogaster.
Progeria and
lamin A processing in mammalian cells; ubiquitin - proteasome mediated
protein quality control in yeast.
A rare, premature aging disease, Hutchinson - Gilford progeria is caused by a single point mutation in the gene encoding
lamin A, which forms a
protein scaffold on the inner edge of the nucleus that helps maintain chromatin structure and organize nuclear processes such as RNA and DNA synthesis.