A side view of
the lamprey gut, showing many large serotonergic neurons (green) sitting on the side of the gut.
«We were interested in the origins of
lamprey gut neurons because in other vertebrates they arise from a particular embryonic cell type, called neural crest cells,» says Stephen Green, postdoctoral scholar in biology and biological engineering and co-first author on the paper.
Not exact matches
But Bronner and her team noticed that while mature
lamprey have
gut neurons like other vertebrates,
lamprey embryos lack these vagal cells.
«Adult
lamprey have
gut neurons, but we were unable to find the vagal precursor cells,» says Bronner.
«We knew that
lamprey have many kinds of neural crest cells, but we knew little about which cells give rise to
gut neurons.»
«
Lamprey have relatively simple
guts, with no looping and few total neurons.
Lamprey show that vertebrates once might have relied on a different mechanism for developing neurons in the
gut.
Bronner was especially interested in how the
lamprey compares with other vertebrates in the evolution of its
gut neurons.