Sentences with phrase «large animal»

«This study provides proof - of - concept experiments, in large animal models, that a small, miniaturized device can be safely implanted in the brain and provide miniaturized control of the electrical activity and function of single neurons or small groups of neurons.

He has also been involved in vaccine research using small and large animal models, e.g. pigs.

All together INRA facilities power up (1) Research in multi-disciplinary domains through academic and industrial collaborations for the development of large animal models, therapeutics or new imaging devices, and (2) Training under several topics (biocontained experiments, introduction of new imaging methods for large animal models etc.), welcoming external teams which do not possess such an instrumental park for Transnational access.

IDMIT is an infrastructure for preclinical research in infectious diseases and immunology which is certified ISO9001 and which includes 1) A large animal facility with capacity to host NHP in BSL2 and BSL3 containment, 2) State - of - the - art laboratories for cell biology, immunology, molecular biology, flow cytometry and mass cytometry (CyTof), cell - sorting and confocal microscopy in BSL3 containment; 3) A biological resources centre with high storage capacity; 4) Highly innovative technologies for in vivo imaging of large animals in BSL2 and BSL3 containment, including a two - photon microscope, a PET - CT facility, and several optic based technologies (fibered endo - microscopy, near infra - red imaging).

Our finding of similarity in clinical progression between human patients and Huntington's disease monkeys suggests monkeys could become a preclinical, large animal model for the development of new treatments.»

Rajesh Kana and Lauren LiberoIn an ancient Indian parable, a group of blind men touches different parts of a large animal to find what it is.

Access unique research animal models through Wake Forest Innovations, including a world - class nonhuman primate center and other large animal research models.

These findings are promising for developing a preclinical, large animal model of Huntington's disease for assessing new therapeutics, which could ultimately provide better treatment options, including altering the course of the disease.

Ongoing comparative analysis will provide insights to help us understand gene function across all large animal species, including humans.»

The researchers are performing tests in large animal models as the next step toward human studies.

In large animal tests, they have achieved a relative error of 8 percent.

Biris's long - time research partner, Dr. David Anderson, is professor and head of Large Animal Clinical Sciences at the University of Tennessee College of Veterinary Medicine (UTCVM).

They are clearly parts of bigger bones from a large animal.

Another larger fragment is composed of spongy bone originating from the end of a large animal's limb.

The team found that in large animal models, the capsule safely stayed in the stomach, slowly releasing the drug for up to 14 days, and potentially providing a new way to combat malaria and other infectious diseases.

While Emmons is intrigued by Oren's hunt, she says the chances of such a thing being anywhere in the Amazon are minuscule because naturalists have been poking around there for centuries: «I've never heard anyone mention anything that is something we don't know about, particularly a large animal.»

Unlike early human hunter - gatherer groups, Neanderthals concentrated almost entirely on hunting big game, as evidenced by the abundance of large animal bones in Neanderthal archaeological sites.

«Compared to mice, our large animal stroke model is a more rigorous test of potential therapeutics with findings that are likely more clinically relevant,» said Franklin West, an associate professor in the College of Agricultural and Environmental Sciences and senior author of the paper describing the model.

Large Animal Research Group, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.

The research team is now starting to test the robotic system in a large animal model of short bowel syndrome.

Additionally, although carrion flies mainly home in on large animal carcasses, other invertebrate surveyors could help scientists study different ecosystem layers — for instance, carrion beetles, which feast on smaller carcasses, including those of birds.

«Large animal models of human disease, like cats, are really helpful for determining what's going to happen in a child when you're treating them,» Vite said.

The octopus's musculature stands in for a skeleton, giving it a flexible structure so that a large animal is able to squeeze into a small space.

The team hopes to get support to continue its tests of the device in large animal models, and eventually conduct clinical trials.

The robotic system, described today in Science Robotics, induced cell proliferation and lengthened part of the esophagus in a large animal by about 75 percent, while the animal remained awake and mobile.

In an ancient Indian parable, a group of blind men touches different parts of a large animal to find what it is.

Humans have played a role in large animal extinctions since time immemorial.

«Pig model of Huntington's offers advantages for testing treatments: Large animal model of neurodegeneration similar to human.»

«The dog has a retina very similar to ours, much more so than mice, so when you want to bring a visual therapy to the clinic, you want to first show that it works in a large animal model of the disease,» said lead researcher Ehud Isacoff, professor of molecular and cell biology at UC Berkeley.

For example, the ratio of the engine to aircraft size is analogous to the ratio of a large animal's total body size to its heart, lungs and muscles.»

«Use of such a clinically - relevant large animal model allows us to begin tackling the next challenges on the road to translating this novel therapeutic strategy to human patients.»

But as today's large animal populations become more in danger of extinction, the environment too is at risk.

In a paper currently in review at the journal Oryx Hamburg University zoologist Jrg Ganzhorn and his colleagues report that at least three of Madagascars unique ecosystems have sustained so much damage that many of the resident large animal species, including a number of lemurs, have disappeared from them.

Furthermore, the researchers suspect that even if habitat destruction were to halt in these areas, the remaining large animal species would have little chance of maintaining viable populations beyond the next few decades.

Still, Angelika Schnieke from the Technical University of Munich, Freising - Weihenstephan, in Germany says that she and her colleagues are trying to ensure they follow the animal welfare principle of minimizing animal use through a European program to coordinate the development of large animal models.

The study found that 8,600 families of genes are shared across deuterostomes, a large animal grouping that includes a variety of organisms, ranging from acorn worms to star fishes, from frogs to dogs, to humans.

«We report here a gene therapy dose - finding study in a large animal model of a severe muscle disease where a single treatment resulted in dramatic rescue,» said Childers.

In addition, the researchers noted, there are no large animal models for age - related macular degeneration that faithfully replicate features of the human condition.

The Wildlife Conservation Society's George Schaller talks about his new book, «A Naturalist and Other Beasts,» which covers his 50 years of documenting important large animal species in the field.

«Under geological aspects, the small number of so few large animal species presents an anomaly,» explains Professor Dr. Hervé Bocherens of the Senckenberg Center for Human Evolution and Palaeoenvironment at the University of Tübingen, and he continues, «The most prominent example of prehistoric giants is, of course, the dinosaurs.»

In simple terms, the overkill hypothesis states that modern man exterminated many of the large animal species on arrival in the new continents.

Principal stationary pollution sources include chemical plants, coal - fired power plants, oil refineries, nuclear waste disposal activity, incinerators, large animal farms, PVC factories, metals production factories, plastics factories, and other heavy industry.

Analysis suggests it was probably fashioned from the bladder of some large animal, perhaps a woolly rhinoceros, and was at one time attached to some long, thin bones found arrayed around the impression.

«This study highlights the importance of confirming the validity of potential biomarkers in a relevant, large animal model and will be useful in the design of future clinical trails,» commented lead investigator Stephen J. Kolb, MD, PhD, Associate Professor, Department of Neurology and Biological Chemistry & Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH.

Christina Nagel, Christine Aurich and their team from Vetmeduni Vienna's Centre for Artificial Insemination and Embryo Transfer have now analysed for the first time the efficiency of simulator - based training in large animal gynaecology.

The study took advantage of an important large animal model of SMA, the SMA piglet developed by the research group.

«Before this study, it was not known if it is possible to produce sufficient numbers of these cells and successfully use them to remuscularize damaged hearts in a large animal whose heart size and physiology is similar to that of the human heart,» said Dr. Charles Murry, UW professor of pathology and bioengineering, who led the research team that conducted the experiment.

The Irish wolfhound stands a metre high and weighs as much as 30 chihuahuas, but the difference in size between the two is due to a single gene, which comes in one form in the large animal and another in the small.

The laboratories also collaborated to successfully prove that reversing a protein deficiency through gene therapy is effective in improving and stabilizing SMA in a large animal model.

But why didn't evolution produce any large animal with more than two eyes?