Sentences with phrase «large animal models»

Screening of the pure - bred dog population for new forms of PRA represents an important strategy to maintain breed health and to establish new large animal models.

The screening of the pure - bred dog population for new forms of PRA represents an important strategy to establish new large animal models.

Dr. Gonzalez» research has aimed to develop and utilize large animal models to translate lab bench findings into clinically relevant therapeutic interventions that benefit both human and veterinary patients.

In large animal models of heart failure, the researchers found that gene therapy delivery of high dose SUMO - 1 alone, as well as SUMO - 1 and SERCA2 together, result in stronger heart contractions, better blood flow, and reduced heart volumes, compared to just SERCA2 gene therapy alone.

«This study provides proof - of - concept experiments, in large animal models, that a small, miniaturized device can be safely implanted in the brain and provide miniaturized control of the electrical activity and function of single neurons or small groups of neurons.

He has also been involved in vaccine research using small and large animal models, e.g. pigs.

All together INRA facilities power up (1) Research in multi-disciplinary domains through academic and industrial collaborations for the development of large animal models, therapeutics or new imaging devices, and (2) Training under several topics (biocontained experiments, introduction of new imaging methods for large animal models etc.), welcoming external teams which do not possess such an instrumental park for Transnational access.

The researchers are performing tests in large animal models as the next step toward human studies.

The team found that in large animal models, the capsule safely stayed in the stomach, slowly releasing the drug for up to 14 days, and potentially providing a new way to combat malaria and other infectious diseases.

«Large animal models of human disease, like cats, are really helpful for determining what's going to happen in a child when you're treating them,» Vite said.

The team hopes to get support to continue its tests of the device in large animal models, and eventually conduct clinical trials.

Still, Angelika Schnieke from the Technical University of Munich, Freising - Weihenstephan, in Germany says that she and her colleagues are trying to ensure they follow the animal welfare principle of minimizing animal use through a European program to coordinate the development of large animal models.

In addition, the researchers noted, there are no large animal models for age - related macular degeneration that faithfully replicate features of the human condition.

Hingtgen's group is already testing how far their tumor - homing cells can migrate using larger animal models.

The laboratories also collaborated to successfully prove that reversing a protein deficiency through gene therapy is effective in improving and stabilizing SMA in a large animal model.

The study took advantage of an important large animal model of SMA, the SMA piglet developed by the research group.

«This study highlights the importance of confirming the validity of potential biomarkers in a relevant, large animal model and will be useful in the design of future clinical trails,» commented lead investigator Stephen J. Kolb, MD, PhD, Associate Professor, Department of Neurology and Biological Chemistry & Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH.

«We report here a gene therapy dose - finding study in a large animal model of a severe muscle disease where a single treatment resulted in dramatic rescue,» said Childers.

«That knowledge has already allowed us to create a cocktail of monoclonal antibodies that we are testing in larger animal models for possible use in treating infected patients,» adds Dr. Bornholdt.

«Use of such a clinically - relevant large animal model allows us to begin tackling the next challenges on the road to translating this novel therapeutic strategy to human patients.»

«The dog has a retina very similar to ours, much more so than mice, so when you want to bring a visual therapy to the clinic, you want to first show that it works in a large animal model of the disease,» said lead researcher Ehud Isacoff, professor of molecular and cell biology at UC Berkeley.

«Pig model of Huntington's offers advantages for testing treatments: Large animal model of neurodegeneration similar to human.»

The research team is now starting to test the robotic system in a large animal model of short bowel syndrome.

The next step will be to demonstrate efficacy in larger animal models, as well as test whether this approach can be used to protect against or treat other diseases.

These findings are promising for developing a preclinical, large animal model of Huntington's disease for assessing new therapeutics, which could ultimately provide better treatment options, including altering the course of the disease.

Our finding of similarity in clinical progression between human patients and Huntington's disease monkeys suggests monkeys could become a preclinical, large animal model for the development of new treatments.»

These are parameters that we will evaluate in a future project in a larger animal model, since small animals are difficult to handle and in several occasions tend to die within the process from stress.

The Evaluation of a Biphasic Osteochondral Implant Coupled with an Electrospun Membrane in a Large Animal Model.

Conceptually related studies were successful in a large animal model.

This large animal model is helping scientists to track altered substances in the blood that could predict HD progression and response to treatment.

Our results demonstrate that CD40 - B can stimulate immune responses in vivo that impact second remission and survival in a spontaneous, large animal model of NHL.

Not exact matches

The Volvo S90 2017 model banners its «moose detector,» a trio of radar, camera and software aimed at identifying large animals on the road and avoiding situations such as car - deer collisions.

This week in Nature Communications, an interdisciplinary team of scientists proposes a more nuanced model for extinction that also shows why animal species tend to evolve toward larger body sizes.

In a paper published in the journal Systematic Biology and delivered at the Society for Molecular Biology and Evolution Conference this week, Dr Phillips said biases in models of DNA evolution inflated estimates of when modern mammals, which were once no larger than a guinea pig, diversified and evolved into the animals familiar to us today.

The researchers found that the immune cells in the skin of this animal model generated large amounts of the cytokine IL - 17 — a protein of the immune system that activates cellular inflammation in response to damage.

From here, we'll be optimizing the delivery system, evaluating the approach in more severe models of DMD, and assessing efficiency and safety in larger animals with the eventual goal of getting into clinical trials.»

A good model system for research is provided by Oesophagostomum dentatum, a roundworm which infects the large intestines of pigs, slowing the animals» growth and leading to significant economic losses.

Chief among the criticisms were the animal's hindlimbs, significantly smaller compared with other large predatory dinosaurs, as well as other researchers» theoretical Spinosaurus models.

The study is one of the first to test if the «landscape of fear» model, a scientific theory that has been used to explain how animals move and interact with the environment based on their fear of being attacked by their predators, is applicable to large open marine systems involving wide - ranging species, like sharks and turtles.

Scaling their model up to a shark 21 feet long and weighing 7,300 pounds — akin to the largest of living white sharks — they found that such an animal opening its jaws to a 35 degree angle could squeeze its prey with almost 4,000 pounds of force.

While more data are needed to improve the model, and it is unclear if it can be extrapolated to animals of much larger body mass, the researchers hope that it might help predict features of non-avian dinosaur locomotion using data from fossils and footprints.

They said my grant proposal was too preliminary, not focused, too ambitious, just a descriptive survey, a large fishing expedition, did not have an adequate animal model, did not provide a clear rationale, and was viewed with a low level of enthusiasm.

The model shows that if animals are still doing what they did before habitat damage caused by decades of agricultural intensification, then large, early - nesting species such as great tits will be fine, but late - nesting species such as tree sparrows will decline.

«Compared to mice, our large animal stroke model is a more rigorous test of potential therapeutics with findings that are likely more clinically relevant,» said Franklin West, an associate professor in the College of Agricultural and Environmental Sciences and senior author of the paper describing the model.

Berg's ongoing battle to defend NIH's National Center for Research Resources, which provides resources like large instruments and animal models, has burnished his image among many scientists who were already fans.

This study was designed to use readily available agents in an accepted large - animal model of human heart attack with the goal of obtaining evidence that this treatment is ready to be moved into human clinical trials.»

The $ 1.3 billion center, which funds biomedical resources such as large instruments and animal models, is slated to have its programs spread among other NIH institutes on 1 October under a controversial plan by NIH Director Francis Collins to create a National Center for Advancing Translational Sciences (NCATS).

A researcher describes how his mathematical model based on heat diffusion reveals the critical role played by large animals in dispersing nutrients

Access unique research animal models through Wake Forest Innovations, including a world - class nonhuman primate center and other large animal research models.

In a previous study, Lonard and co-senior study author Bert O'Malley of Baylor College of Medicine screened a large number of compounds to identify SRC - inhibiting molecules that kill a wide variety of cancer cells and inhibit tumor growth in animal models.