Sentences with phrase «large change in conditions»

In fact, when ablation is dominated by sublimation, it takes a very large change in conditions (e.g. solar absorption) to appreciably affect ablation.

Not exact matches

But if climate change isn't stabilized soon, the authors wrote,» [t] he large - scale loss of functionally diverse corals is a harbinger of further radical shifts in the condition and dynamics of all ecosystems, reinforcing the need for risk assessment of ecosystem collapse.»

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Rapid demand growth; commodity price volatility; the influence of a broad range of global conditions on wages: all these factors can trigger large changes in relative prices, and this makes the job of capturing underlying inflation harder.

Financial conditions affect households» and firms» decisions, so that the transmission of U.S. monetary policy to the real economy depends, to a large extent, on how changes in monetary policy help deliver the appropriate financial market conditions to support our objectives of price stability and maximum employment.

When conditions change in certain ways, however, the differences can become too large to ignore.

Both the perceived change in credit availability compared to a year ago and one - year ahead credit availability expectations improved in September, with a larger fraction of respondents reporting easier credit conditions.

The fund may also invest in small - and mid-capitalization companies, which can be particularly sensitive to changing economic conditions, and their prospects for growth are less certain then those of larger, more established companies.

Additionally, the legislation left in place a large number of legal requirements in the ACA, including the essential benefits package requirements, the prohibition on insurers denying or charging more for coverage for those pre-existing conditions, the limits on «medical loss ratios,» and other changes that do not have a direct budgetary effect.

He went out in later years to change the conditions in mine and factory for the laborer, and he succeeded so well that Matthew Arnold said the average Englishman thought of God as Lord Shaftesbury on a larger scale.

Information for patients and the public will help enforce the step change needed in antimicrobial prescribing, particularly for conditions like coughs and colds that may get better without such intervention in the large majority of cases.

Moreover, while moratoria on executions should be welcomed, if they are not accompanied by a change in judicial practice, long - term moratoria result in a large number of people languishing on «death row», a condition which may amount to cruel, inhuman or degrading treatment.

It tests in detail the effects of three alternative formulae across different election scenarios 2015 - 25 — looking at how they would perform under conditions of large, medium and small electoral change.

MATH GETS REAL Chaos theory explains why it's so difficult to predict weather — a small change in conditions at any point in time can have a large effect on future conditions in, for example, a hurricane's trajectory (Tropical Storm Harvey shown).

A universal eye contact detector, usable for both small and large target objects, in stationary and mobile situations, for one user or a whole group, or under changing lighting conditions, was hitherto nearly impossible.

In addition to helping farmers check crop health, the new system will be helpful for studying how plants respond to changes in growing conditions and for high - throughput phenotyping, an automated method used in crop research and development to analyze how genetic modifications affect plant characteristics such as leaf size or drought resistance in a large number of plantIn addition to helping farmers check crop health, the new system will be helpful for studying how plants respond to changes in growing conditions and for high - throughput phenotyping, an automated method used in crop research and development to analyze how genetic modifications affect plant characteristics such as leaf size or drought resistance in a large number of plantin growing conditions and for high - throughput phenotyping, an automated method used in crop research and development to analyze how genetic modifications affect plant characteristics such as leaf size or drought resistance in a large number of plantin crop research and development to analyze how genetic modifications affect plant characteristics such as leaf size or drought resistance in a large number of plantin a large number of plants.

Evolution and economics are not just analogous to each other, but they are actually two forms of a larger phenomenon called complex adaptive systems, in which individual elements, parts or agents interact, then process information and adapt their behavior to changing conditions.

«Altogether our study highlights how sensitive regional weather conditions are to any changes in large - scale atmosphere dynamics,» says Coumou.

«Previous efforts have focused on tornado reports, but the connection with changes in large - scale conditions hadn't been made,» he said.

A recent study published in Scientific Reports, led by researchers of the University of Barcelona in collaboration with several other research institutions, shows that the direct effect of climate change in regulating fuel moisture (droughts leading to larger fires) is expected to be dominant, regarding the indirect effect of antecedent climate on fuel load and structure - that is, warmer / drier conditions that determine fuel availability.

«The species lives in habitats that are exposed to large changes in ocean conditions and have limited scope to avoid these changes.»

We ran two very large «ensembles» of weather simulations, one representing conditions and «possible weather» in the winter we have just had, and one representing the weather in a «world that might have been» if we had not changed the composition of the atmosphere through greenhouse gas emissions.

The PNNL scientists found that RNAP exists as a large supramolecular complex whose protein composition substantially changes in response to growth conditions.

As the resolution of Google Earth and satellite images increases, checking between images and the ground condition will provide a powerful way of tracking changes in large populations of circles.

In short, this method requires large short - term changes in your consumption of carbs, sodium and water, and is usually implemented by depleting carbs for several days and then reloading your muscles with glycogen, which creates miraculous changes in muscle conditioninIn short, this method requires large short - term changes in your consumption of carbs, sodium and water, and is usually implemented by depleting carbs for several days and then reloading your muscles with glycogen, which creates miraculous changes in muscle conditioninin your consumption of carbs, sodium and water, and is usually implemented by depleting carbs for several days and then reloading your muscles with glycogen, which creates miraculous changes in muscle conditioninin muscle conditioning.

Downsizing sees Payne and Taylor working on a larger palette than usual, but like their shrunken characters, the filmmakers» humor and their sharp observation of the human condition have survived the change in size and scope.

In their approach, large changes in external conditions (what Baumgartner and Jones term an «exogenous shock») are often needed to produce change in complex social and political systemIn their approach, large changes in external conditions (what Baumgartner and Jones term an «exogenous shock») are often needed to produce change in complex social and political systemin external conditions (what Baumgartner and Jones term an «exogenous shock») are often needed to produce change in complex social and political systemin complex social and political systems.

Often, the authors of these studies provided a discussion that set the findings of impact on teacher practice in the larger context of conditions supportive of change in schools, of which teacher leader actions were a piece.

With these conditions in mind, states should prepare for larger year - to - year changes in value - added in the 2014 - 15 school year when they switch to tests aligned with the Common Core.

As Little (1993) suggests, instructional change is dependent on teachers» opportunities to learn about new ideas and adapt them to local conditions (McLaughlin, 1987; Standerford, 1997); districts have a large hand in determining the nature, frequency, and effectiveness of these learning opportunities.

More small improvements include a one - piece welded exhaust system that uses one big muffler branching into two tailpipes to reduce squeaks and rattles; self - adjusting clutch linkage; headlights that project a beam that is wider near the car and extends 10 percent farther down the road; changes to the climate - control system that result in faster heating and more durable air conditioning; new 16 - inch aluminum wheels; and a larger torque converter on the V - 8 automatic.

VOICE - ACTIVATED TOUCH - SCREEN NAVIGATION SYSTEM - inc: pinch - to - zoom capability, SiriusXM Traffic and Travel Link w / a 5 - year prepaid subscription, SiriusXM audio and data services each require a subscription sold separately, or as a package, by SiriusXM Radio Inc, If you decide to continue service after your trial, the subscription plan you choose will automatically renew thereafter and you will be charged according to your chosen payment method at then - current rates, Fees and taxes apply, To cancel you must call SiriusXM at 1-866-635-2349, See SiriusXM Customer Agreement for complete terms at www.siriusxm.com, All fees and programming subject to change, Sirius, XM and all related marks and logos are trademarks of Sirius XM Radio Inc, SAFE & SMART PACKAGE - inc: Adaptive Cruise Control, Blind Spot Info System w / Cross-Traffic Alert, Pre-Collision Assist w / Pedestrian Detection, automatic emergency braking and forward collision warning w / brake support, Memory Driver Seat, Mirrors & Ambient Lighting, 3 settings, Lane Keeping Alert, Automatic High Beam, Rain - Sensing Windshield Wipers, RADIO: SHAKER PRO AUDIO SYSTEM - inc: 12 - speakers and subwoofer in trunk, HD Radio, MAGNERIDE DAMPING SYSTEM, FRONT LICENSE PLATE BRACKET - inc: Standard in states where required by law, EQUIPMENT GROUP 200A, ENHANCED SECURITY PACKAGE - inc: electronic - locking center console and electronic steering column lock, Active Anti-Theft System, Wheel Locking Kit, ECOBOOST PERFORMANCE PACKAGE - inc: black painted strut tower brace, performance rear wing, unique chassis tuning, unique electronic power assisted steering, unique anti-lock brakes, stability control tuning and upsized rear sway bar, Larger Brake Rotors, 4 - piston fixed calipers, Engine Spun Aluminum Instrument Panel, Gauge Pack (Oil Pressure and Boost), Wheels: 19» x 9» Ebony Black - Painted Aluminum Low gloss, 3.55 TORSEN Limited Slip Rear Axle, HD Front Springs, Larger Radiator, Tires: P255 / 40R19 Summer - Only Designed to optimize driving dynamics and provide superior performance on wet and dry roads, High performance summer tires wear faster than non-performance tires, Ford does not recommend using summer tires when temperatures drop to approximately 45 deg F (7 deg C) or below or in snow / ice conditions, CARBON SPORT INTERIOR PACKAGE - inc: Alcantara door inserts, Alcantara seat inserts, carbon fiber instrument panel and carbon fiber shift knob, Wireless Streaming.

Given its larger load capacity, the 5 Series Touring also features a standard self - levelling air suspension on the rear that immediately takes account of, and compensates for, changes in load to provide a constant vehicle height under all driving and load conditions.

Improvements include a larger diffuser for more efficient aero, double wishbone front suspension adopted from the RSR, a shim system allowing setup changes without new alignment, larger front tyres, an electro - hydraulically actuated clutch allowing the removal of the clutch pedal, a fuel cell that can be configured to be refilled from left or right of the vehicle depending on circuit layout, a rear - view camera and collision avoidance system, a fixed seat with movable pedal - box and energy - absorbing impact elements placed in the doors for improved safety as well as air conditioning.

Blending the comfort of a Mercedes S - Class with the style of a Coupe the performance pedigree of Mercedes tuning arm, the all - new S 63 AMG Coupe is a tantalising proposition, It's design offers exclusivity and luxury to match a Bentley Continental GT with the promise of handling and performance to rival the flagship Porsche Panamera, and aims to be the ultimate luxury all - rounder, Despite getting the S - Class name, the new Coupe stands out enough from the limousine on which its based, Sharp creases down the sides, a long bonnet, sloping roof and a neat spoiler integrated into the boot lid do a great job of shrinking the S - Class Coupes large dimension.;;» «MEGA SPEC»»; Our example is finished in magnetite Black and trimmed with Black Nappa leather with white stitching and AMG badges, Walnut Veneer Wood Interior, The car comes with the 360 Camera, Distronic system, Active Park Assist, Lane Assist, Brake Assist Plus, Steering Assist, Blind spot Assist, Night view Assist, Head up display, Lane Change Warning, Burmeister Sound System, Memory Package, Dual Cup Holder, MB Connect, Dynamic Front Seats with Hot / Cold and Massage Seats, Electric Roller Blind, Active Body Control, Eco Start Stop, Dynamic LED Lights, Ambient Lighting, AMG 20» Spoked Wheels, Silver Brake Calipers, Adaptive Air Suspension, AMG Sports Package, Full MB Service History, Heated Seats, Keyless Go, Panoramic Glass Roof, Power Soft Close, Satellite Navigation, Memory Electric Seats, 14 Way Electric Adjustable Front Seats, Air Conditioning, Bluetooth Telephone, Central Locking, Climate Control, DAB Digital Radio, Heated Folding Mirrors, Massage Front Seats, Park Distance Control, Reversing Camera with Guidance Lines, 8 Speed Gearbox, AMG 3 - Spoke Sports Steering Wheel, Multi Function Steering Wheel, Multiple Airbags, Anti Glare Rear View Mirrors, CD Auto changer, Day Time Running Lights, Electric Remote Boot / Hatch / Door Release, Light Design Package, Push Button Start, 2 Former Keepers, Black.

Aside from changes in credit, the two largest conditions involve the appraisal on the property you hope to purchase and a final approval from the lender's underwriting experts.

The principal risks of investing in the Funds are: stock market risk (stocks fluctuate in response to the activities of individual companies and to general stock market and economic conditions), stock selection risk (Fenimore utilizes a value approach to stock selection and there is risk that the stocks selected may not realize their intrinsic value, or their price may go down over time), and small - cap risk (prices of small - cap companies can fluctuate more than the stocks of larger companies and may not correspond to changes in the stock market in general).

There are additional risks related to large institutional purchases or sales, changes in exchange rates, government regulation, world events, economic and political conditions in the countries where energy companies are located or do business, and risks for environmental damage claims.

There are additional risks related to commodity investments due to large institutional purchases or sales, changes in exchange rates, government regulation, world events, economic and political conditions in the countries where energy companies are located or do business, and risks for environmental damage claims, as well as natural and technological factors such as severe weather, unusual climate change, and development and depletions of alternative resources.

In addition to large - cap companies, the Fund may invest in small - and / or mid-cap companies, which can be particularly sensitive to changing economic conditions and have fewer financial resources or the well - established businesses of large - cap companieIn addition to large - cap companies, the Fund may invest in small - and / or mid-cap companies, which can be particularly sensitive to changing economic conditions and have fewer financial resources or the well - established businesses of large - cap companiein small - and / or mid-cap companies, which can be particularly sensitive to changing economic conditions and have fewer financial resources or the well - established businesses of large - cap companies.

These conditions may be simple to fix (such as a change in diet or regular grooming), may be causing your beloved pet a lot of discomfort, and could possibly indicate a larger problem.

Q: Dr Mike, could you tell me is the operation for a large soft palate in a 1 yr old pug simple or are there dangers?She was spayed recently and while under the anaseithic was found to have a very large soft palate.She is very nervy and tense for a pug and at times quite growly towards our other pug.She showed signs of this behavior before being spayed and has started doing this again, also I don't know if it is normal or not but her nails are changing from black to white, still good and strong just changing colour.Where we are in New Zealand there is not much information available about conditions like soft palate's etc; as pugs aren't all that common.I would appreciate any advice you can give me.

Animal Welfare groups and volunteers are attempting to change that point of view by educating owners and potential owners about the lifelong commitment involved in adopting an animal, how to be a responsible pet owner, about the large number of adoptable animals available at shelters, and about the often poor condition of pet shop pets.

Changes in serum biochemistry profile for dogs with hepatic tumors may also indicate hypoglycemia, hypoalbuminemia (levels of albumin in blood serum are abnormally low), hyperglobulinemia (condition characterized by large amounts of globulins [any class of proteins not soluble in water but soluble in saline solution] in blood) and increased pre and post prandial bile acids (before and after eating a meal).

The large - scale sculptures, which begin as small folded paper models, combine the concept of monumental and permanent, emanating at the same time the sense of a potential change and erosion — similarly Falls did in his former project in Zabludowicz residency program in Finland, where some hand - dyed fabrics exposed to the natural elements created new objects and photographic records of the various environmental conditions.

[2011 Paper — Cited by 493 times] Transformational adaptation when incremental adaptations to climate change are insufficient Two conditions set the stage for transformational adaptation to climate change: large vulnerability in certain regions, populations, or resource systems; and severe climate change that overwhelms even robust human use systems.

The paleoclimate record (8.2 kyr, and earlier «large lake collapses») shows a dramatic drop in surface temperatures for a substantial period of time when the ocean circulation shuts off or changes, but is that actually what would be expected under these warming conditions?

Effects of harvest and climate change on polar marine ecosystems: case studies from the Antarctic Peninsula and Hudson Bay C Hoover — 2012 — circle.ubc.ca... Future simulations of the Antarctic Peninsula identify large reductions in ecosystem biomass of all species due changes in environmental conditions and an overall reduction in krill, with minimal ecosystem impacts from harvest.

The conclusion that they survived over at least two glacial cycles, where the amplitude of environmental change in the Arctic is quite large, suggests they have under natural conditions the ability to adapt / survive such changes.

What you guys will not come clean about however, is that these initial conditions of the ocean / atmosphere also impart a large range of uncertainty on multi-decadal predictions, even though you are invoking changes in boundary values to gain skill.