Sentences with phrase «large changes in function»

«We don't necessarily need to completely change the active site to achieve very large changes in function.»

Not exact matches

The speech lists five key fundamentals that should stand Australia in good stead: a strong institutional framework (including the rule of law, respect for property rights, a well - functioning public administration, and a well - established regulatory system); our people, who are diverse, well educated, have a «can do» mentality and a demonstrated capability for adjusting to change; a large endowment of mineral resources; large tracts of agricultural land and an ability to produce high - quality clean food; and an established services industry with the potential for considerable expansion as average incomes in Asia rise.

When the Canadian labour market is functioning normally, there are large flows of hires into employment and not - quite - so large flows of separations out of employment: the relatively small difference between the two is the change in total employment.

In its analysis of administration cost savings caused by the Public Bodies Reform programme, the National Audit Office (NAO) decided to exclude bodies associated with the Department of Health (the department subject to the largest administration cost changes), saying «the major reorganisation and transfer of functions between NHS bodies since 2010 made the analysis too problematic» (NAO 2014, p. 40).

Researchers in this group think that these functions will dramatically increase construction equipment's capacity to deal with large - scale disasters and accidents and believe it is possible that the replacement of conventional construction equipment with this robot will drastically change civil engineering and construction methods.

The function of these genes were involved in molecular maintenance strategies, such as DNA repair, chromosomal maintenance, immune response and programmed cell death The authors argue that the «slower rate of change in these functions is consistent with increased constraint on somatic cell maintenance as would be required in these relatively long - lived and large - bodied mammals, illustrated by the additional large and long - lived species with slower rates in these genes (e.g. double - strand break repair gene XRCC4 is also highly constrained in elephant.»

g (acceleration due to gravity) G (gravitational constant) G star G1.9 +0.3 gabbro Gabor, Dennis (1900 — 1979) Gabriel's Horn Gacrux (Gamma Crucis) gadolinium Gagarin, Yuri Alexeyevich (1934 — 1968) Gagarin Cosmonaut Training Center GAIA Gaia Hypothesis galactic anticenter galactic bulge galactic center Galactic Club galactic coordinates galactic disk galactic empire galactic equator galactic habitable zone galactic halo galactic magnetic field galactic noise galactic plane galactic rotation galactose Galatea GALAXIES galaxy galaxy cannibalism galaxy classification galaxy formation galaxy interaction galaxy merger Galaxy, The Galaxy satellite series Gale Crater Galen (c. AD 129 — c. 216) galena GALEX (Galaxy Evolution Explorer) Galilean satellites Galilean telescope Galileo (Galilei, Galileo)(1564 — 1642) Galileo (spacecraft) Galileo Europa Mission (GEM) Galileo satellite navigation system gall gall bladder Galle, Johann Gottfried (1812 — 1910) gallic acid gallium gallon gallstone Galois, Évariste (1811 — 1832) Galois theory Galton, Francis (1822 — 1911) Galvani, Luigi (1737 — 1798) galvanizing galvanometer game game theory GAMES AND PUZZLES gamete gametophyte Gamma (Soviet orbiting telescope) Gamma Cassiopeiae Gamma Cassiopeiae star gamma function gamma globulin gamma rays Gamma Velorum gamma - ray burst gamma - ray satellites Gamow, George (1904 — 1968) ganglion gangrene Ganswindt, Hermann (1856 — 1934) Ganymede «garbage theory», of the origin of life Gardner, Martin (1914 — 2010) Garneau, Marc (1949 ---RRB- garnet Garnet Star (Mu Cephei) Garnet Star Nebula (IC 1396) garnierite Garriott, Owen K. (1930 ---RRB- Garuda gas gas chromatography gas constant gas giant gas laws gas - bounded nebula gaseous nebula gaseous propellant gaseous - propellant rocket engine gasoline Gaspra (minor planet 951) Gassendi, Pierre (1592 — 1655) gastric juice gastrin gastrocnemius gastroenteritis gastrointestinal tract gastropod gastrulation Gatewood, George D. (1940 ---RRB- Gauer - Henry reflex gauge boson gauge theory gauss (unit) Gauss, Carl Friedrich (1777 — 1855) Gaussian distribution Gay - Lussac, Joseph Louis (1778 — 1850) GCOM (Global Change Observing Mission) Geber (c. 720 — 815) gegenschein Geiger, Hans Wilhelm (1882 — 1945) Geiger - Müller counter Giessler tube gel gelatin Gelfond's theorem Gell - Mann, Murray (1929 ---RRB- GEM «gemination,» of martian canals Geminga Gemini (constellation) Gemini Observatory Gemini Project Gemini - Titan II gemstone gene gene expression gene mapping gene pool gene therapy gene transfer General Catalogue of Variable Stars (GCVS) general precession general theory of relativity generation ship generator Genesis (inflatable orbiting module) Genesis (sample return probe) genetic code genetic counseling genetic disorder genetic drift genetic engineering genetic marker genetic material genetic pool genetic recombination genetics GENETICS AND HEREDITY Geneva Extrasolar Planet Search Program genome genome, interstellar transmission of genotype gentian violet genus geoboard geode geodesic geodesy geodesy satellites geodetic precession Geographos (minor planet 1620) geography GEOGRAPHY Geo - IK geologic time geology GEOLOGY AND PLANETARY SCIENCE geomagnetic field geomagnetic storm geometric mean geometric sequence geometry GEOMETRY geometry puzzles geophysics GEOS (Geodetic Earth Orbiting Satellite) Geosat geostationary orbit geosynchronous orbit geosynchronous / geostationary transfer orbit (GTO) geosyncline Geotail (satellite) geotropism germ germ cells Germain, Sophie (1776 — 1831) German Rocket Society germanium germination Gesner, Konrad von (1516 — 1565) gestation Get Off the Earth puzzle Gettier problem geyser g - force GFO (Geosat Follow - On) GFZ - 1 (GeoForschungsZentrum) ghost crater Ghost Head Nebula (NGC 2080) ghost image Ghost of Jupiter (NGC 3242) Giacconi, Riccardo (1931 ---RRB- Giacobini - Zinner, Comet (Comet 21P /) Giaever, Ivar (1929 ---RRB- giant branch Giant Magellan Telescope giant molecular cloud giant planet giant star Giant's Causeway Giauque, William Francis (1895 — 1982) gibberellins Gibbs, Josiah Willard (1839 — 1903) Gibbs free energy Gibson, Edward G. (1936 ---RRB- Gilbert, William (1544 — 1603) gilbert (unit) Gilbreath's conjecture gilding gill gill (unit) Gilruth, Robert R. (1913 — 2000) gilsonite gimbal Ginga ginkgo Giotto (ESA Halley probe) GIRD (Gruppa Isutcheniya Reaktivnovo Dvisheniya) girder glacial drift glacial groove glacier gland Glaser, Donald Arthur (1926 — 2013) Glashow, Sheldon (1932 ---RRB- glass GLAST (Gamma - ray Large Area Space Telescope) Glauber, Johann Rudolf (1607 — 1670) glaucoma glauconite Glenn, John Herschel, Jr. (1921 ---RRB- Glenn Research Center Glennan, T (homas) Keith (1905 — 1995) glenoid cavity glia glial cell glider Gliese 229B Gliese 581 Gliese 67 (HD 10307, HIP 7918) Gliese 710 (HD 168442, HIP 89825) Gliese 86 Gliese 876 Gliese Catalogue glioma glissette glitch Global Astrometric Interferometer for Astrophysics (GAIA) Global Oscillation Network Group (GONG) Globalstar globe Globigerina globular cluster globular proteins globule globulin globus pallidus GLOMR (Global Low Orbiting Message Relay) GLONASS (Global Navigation Satellite System) glossopharyngeal nerve Gloster E. 28/39 glottis glow - worm glucagon glucocorticoid glucose glucoside gluon Glushko, Valentin Petrovitch (1908 — 1989) glutamic acid glutamine gluten gluteus maximus glycerol glycine glycogen glycol glycolysis glycoprotein glycosidic bond glycosuria glyoxysome GMS (Geosynchronous Meteorological Satellite) GMT (Greenwich Mean Time) Gnathostomata gneiss Go Go, No - go goblet cell GOCE (Gravity field and steady - state Ocean Circulation Explorer) God Goddard, Robert Hutchings (1882 — 1945) Goddard Institute for Space Studies Goddard Space Flight Center Gödel, Kurt (1906 — 1978) Gödel universe Godwin, Francis (1562 — 1633) GOES (Geostationary Operational Environmental Satellite) goethite goiter gold Gold, Thomas (1920 — 2004) Goldbach conjecture golden ratio (phi) Goldin, Daniel Saul (1940 ---RRB- gold - leaf electroscope Goldstone Tracking Facility Golgi, Camillo (1844 — 1926) Golgi apparatus Golomb, Solomon W. (1932 — 2016) golygon GOMS (Geostationary Operational Meteorological Satellite) gonad gonadotrophin - releasing hormone gonadotrophins Gondwanaland Gonets goniatite goniometer gonorrhea Goodricke, John (1764 — 1786) googol Gordian Knot Gordon, Richard Francis, Jr. (1929 — 2017) Gore, John Ellard (1845 — 1910) gorge gorilla Gorizont Gott loop Goudsmit, Samuel Abraham (1902 — 1978) Gould, Benjamin Apthorp (1824 — 1896) Gould, Stephen Jay (1941 — 2002) Gould Belt gout governor GPS (Global Positioning System) Graaf, Regnier de (1641 — 1673) Graafian follicle GRAB graben GRACE (Gravity Recovery and Climate Experiment) graceful graph gradient Graham, Ronald (1935 ---RRB- Graham, Thomas (1805 — 1869) Graham's law of diffusion Graham's number GRAIL (Gravity Recovery and Interior Laboratory) grain (cereal) grain (unit) gram gram - atom Gramme, Zénobe Théophile (1826 — 1901) gramophone Gram's stain Gran Telescopio Canarias (GTC) Granat Grand Tour grand unified theory (GUT) Grandfather Paradox Granit, Ragnar Arthur (1900 — 1991) granite granulation granule granulocyte graph graph theory graphene graphite GRAPHS AND GRAPH THEORY graptolite grass grassland gravel graveyard orbit gravimeter gravimetric analysis Gravitational Biology Facility gravitational collapse gravitational constant (G) gravitational instability gravitational lens gravitational life gravitational lock gravitational microlensing GRAVITATIONAL PHYSICS gravitational slingshot effect gravitational waves graviton gravity gravity gradient gravity gradient stabilization Gravity Probe A Gravity Probe B gravity - assist gray (Gy) gray goo gray matter grazing - incidence telescope Great Annihilator Great Attractor great circle Great Comets Great Hercules Cluster (M13, NGC 6205) Great Monad Great Observatories Great Red Spot Great Rift (in Milky Way) Great Rift Valley Great Square of Pegasus Great Wall greater omentum greatest elongation Green, George (1793 — 1841) Green, Nathaniel E. Green, Thomas Hill (1836 — 1882) green algae Green Bank Green Bank conference (1961) Green Bank Telescope green flash greenhouse effect greenhouse gases Green's theorem Greg, Percy (1836 — 1889) Gregorian calendar Grelling's paradox Griffith, George (1857 — 1906) Griffith Observatory Grignard, François Auguste Victor (1871 — 1935) Grignard reagent grike Grimaldi, Francesco Maria (1618 — 1663) Grissom, Virgil (1926 — 1967) grit gritstone Groom Lake Groombridge 34 Groombridge Catalogue gross ground, electrical ground state ground - track group group theory GROUPS AND GROUP THEORY growing season growth growth hormone growth hormone - releasing hormone growth plate Grudge, Project Gruithuisen, Franz von Paula (1774 — 1852) Grus (constellation) Grus Quartet (NGC 7552, NGC 7582, NGC 7590, and NGC 7599) GSLV (Geosynchronous Satellite Launch Vehicle) g - suit G - type asteroid Guericke, Otto von (1602 — 1686) guanine Guiana Space Centre guidance, inertial Guide Star Catalog (GSC) guided missile guided missiles, postwar development Guillaume, Charles Édouard (1861 — 1938) Gulf Stream (ocean current) Gulfstream (jet plane) Gullstrand, Allvar (1862 — 1930) gum Gum Nebula gun metal gunpowder Gurwin Gusev Crater gut Gutenberg, Johann (c. 1400 — 1468) Guy, Richard Kenneth (1916 ---RRB- guyot Guzman Prize gymnosperm gynecology gynoecium gypsum gyrocompass gyrofrequency gyropilot gyroscope gyrostabilizer Gyulbudagian's Nebula (HH215)

Health improvement (allowing to post - pone / escape the diseases and thus live, healthier / disease - free longer, but not above human MLSP of around 122 years; thus these therapies do not affect epigenetic aging whatsoever, they are degenerative aging problems not regular healthy aging problem (except OncoSENS - only when you Already Have Cancer - which cancer increases epigenetic aging, but cancer removal thus does not change anything / makes no difference about what happens in the other cells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to MLSP).

Some of the other tests of brain structure and function were promising, but overall this study indicates that a specific change in nutrition is unlikely to make a large difference to people with Alzheimer's, even in the early stages.

Beyond the well - known function of poly (A) tail length in mRNA stability, recent years have witnessed an explosion of information about how changes in tail length and the selection of alternative polyadenylation sites contribute to the translational regulation of a large portion of the genome.

BETHESDA, MD — Balanced chromosomal abnormalities (BCAs), a category of structural changes to the human genome, may account for a large portion of birth defects related to brain development and function, according to research presented at the American Society of Human Genetics (ASHG) 2015 Annual Meeting in Baltimore.

Persistent inflammation induced by prolonged or repetitive exposure to specific allergens, typically characterized not only by the presence of large numbers of innate and adaptive immune cells (in the form of leukocytes) at the affected site but also by substantial changes in the extracellular matrix and alterations in the number, phenotype and function of structural cells in the affected tissues.

Human growth hormone is not to be dosed to people based on their weight — alcohol tolerance and resistance to anesthesia are at times measured that way because a heavier person has a larger volume that can dilute the alcohol / anesthesia before it hits the system in a way to effect changes in the capacity for normal body function — changes that will only last for a set number of hours.

Blending the comfort of a Mercedes S - Class with the style of a Coupe the performance pedigree of Mercedes tuning arm, the all - new S 63 AMG Coupe is a tantalising proposition, It's design offers exclusivity and luxury to match a Bentley Continental GT with the promise of handling and performance to rival the flagship Porsche Panamera, and aims to be the ultimate luxury all - rounder, Despite getting the S - Class name, the new Coupe stands out enough from the limousine on which its based, Sharp creases down the sides, a long bonnet, sloping roof and a neat spoiler integrated into the boot lid do a great job of shrinking the S - Class Coupes large dimension.;;» «MEGA SPEC»»; Our example is finished in magnetite Black and trimmed with Black Nappa leather with white stitching and AMG badges, Walnut Veneer Wood Interior, The car comes with the 360 Camera, Distronic system, Active Park Assist, Lane Assist, Brake Assist Plus, Steering Assist, Blind spot Assist, Night view Assist, Head up display, Lane Change Warning, Burmeister Sound System, Memory Package, Dual Cup Holder, MB Connect, Dynamic Front Seats with Hot / Cold and Massage Seats, Electric Roller Blind, Active Body Control, Eco Start Stop, Dynamic LED Lights, Ambient Lighting, AMG 20» Spoked Wheels, Silver Brake Calipers, Adaptive Air Suspension, AMG Sports Package, Full MB Service History, Heated Seats, Keyless Go, Panoramic Glass Roof, Power Soft Close, Satellite Navigation, Memory Electric Seats, 14 Way Electric Adjustable Front Seats, Air Conditioning, Bluetooth Telephone, Central Locking, Climate Control, DAB Digital Radio, Heated Folding Mirrors, Massage Front Seats, Park Distance Control, Reversing Camera with Guidance Lines, 8 Speed Gearbox, AMG 3 - Spoke Sports Steering Wheel, Multi Function Steering Wheel, Multiple Airbags, Anti Glare Rear View Mirrors, CD Auto changer, Day Time Running Lights, Electric Remote Boot / Hatch / Door Release, Light Design Package, Push Button Start, 2 Former Keepers, Black.

I liked that the home screen uses large icons that are easy to tap and read when the vehicle is in motion, but I didn't like that I had to return to the home screen whenever I wanted to change the displayed function.

Disruptions to normal colonic function lead to changes in both absorption and motility; clinically, this often manifests as large - bowel diarrhea.

These fights can stretch out and change form as they progress, taking you in unexpected directions that simultaneously challenge the player and comment on the nature of boss fights, the function of the game camera, and the larger themes the game has been working with.

With this video function, we wish to focus in on maybe the largest change.

After that it's just a matter of applying the strong law of large numbers to the partition function, integrating over the allowed linear changes in terrestrial land use, and calculating the average rate of convergence of the continuous time martingale.

In the approach to this limit, when optical thickness is sufficiently large, a linear approximation can be made (remember what was said earlier about small intervals), wherein each doubling results in half the change of the last doubling (that's based on an approximately linear change in temperature relative to optical distances, and an approximately linear change in the Planck function over temperature — applicable for the small distances and small temperature variations impliedIn the approach to this limit, when optical thickness is sufficiently large, a linear approximation can be made (remember what was said earlier about small intervals), wherein each doubling results in half the change of the last doubling (that's based on an approximately linear change in temperature relative to optical distances, and an approximately linear change in the Planck function over temperature — applicable for the small distances and small temperature variations impliedin half the change of the last doubling (that's based on an approximately linear change in temperature relative to optical distances, and an approximately linear change in the Planck function over temperature — applicable for the small distances and small temperature variations impliedin temperature relative to optical distances, and an approximately linear change in the Planck function over temperature — applicable for the small distances and small temperature variations impliedin the Planck function over temperature — applicable for the small distances and small temperature variations implied).

(The PR from a layer will tend to be more evenly distributed between going out the top and out the bottom if either the change in temperature is evenly distributed within the layer, or if the layer has significant but not large optical thickness over a portion of the spectrum (weighted by the Planck function (s) for the temperature (s) involved) considerably greater than any portion where the optical thickness is large.)

Re 392 Chris Dudley — I don't understand what you mean by R ^ 2T ^ 4 — and there should be something about how optical depth is proportional to R, and also, if you're going a significant distance toward the center of such an object, there is the issue of spherical geometry; if the optical thickness is large enough across small changes in radius, then you don't need to account for the spherical geometry in the calculation of the flux per unit area as a function of the temperature profile and optical thickness; however, the flux per unit area outward will drop as an inverse square, except of course within the layers that are being heated through a different process (SW heating for a planet, radioactivity, latent and sensible heat loss associated with a cooling interior, gravitational potential energy conversion to enthalpy via compression (adiabatic warming) and settling of denser material under gravity (the later both leads to compression via increased pressure via increased gravity within the interior, and also is a source of kinetic energy which can be converted to heat)...

When optical thickness is large, the net flux will tend to be small, but the flux will vary with lapse rate (according to the corresponding Planck function «lapse rate») and a sufficiently sharp change in that lapse rate could lead to some significant flux convergence or divergence at that level (net radiant heating or cooling).

http://www.vukcevic.talktalk.net/NFC1.htm http://www.vukcevic.talktalk.net/LFC20.htm Re UV: This is a copy of a note I wrote some 5 - 6 years ago with minor changes (I occasionally quote it here and there since I think it still has some merit) Both UV and the particle radiation (particle radiation is a function of solar activity and the strength of Van Allen belt, via the Earth's field strength) could have far larger indirect contribution by controlling plankton volumes, and in turn changing the oceans» clarity and CO2 absorption.

The reason is that the Planck function change with height (temperature) is very strong in reducing the intensity of those relatively few lines with large absorption coefficients.

Past and future climates changes could conceivably be large enough to engender unforeseen qualitative alterations in the functioning of the climate system.

As previously noted, when considering large - scale averages the Kriging process described here is largely insensitive to the details of the correlation function, so it is expected that small changes in the correlation structure with location or orientation can be safely ignored.

The collaborative international project began in 1993 as an effort to address how Amazonia functions as a regional entity within the larger Earth system, and how changes in land use there might affect the region's biological, chemical, and physical functions and influence global climate.

I also tried to implement their function as a lag that finishes quick for small changes in forcing but drags for larger changes, but the functional form made that delay a long time to get any temperature rise at all with a BAU type emissions profile.

These range from simple averaging of regional data and scaling of the resulting series so that its mean and standard deviation match those of the observed record over some period of overlap (Jones et al., 1998; Crowley and Lowery, 2000), to complex climate field reconstruction, where large - scale modes of spatial climate variability are linked to patterns of variability in the proxy network via a multivariate transfer function that explicitly provides estimates of the spatio - temporal changes in past temperatures, and from which large - scale average temperature changes are derived by averaging the climate estimates across the required region (Mann et al., 1998; Rutherford et al., 2003, 2005).

But speaking to global HR heads at some of the largest UK and global firms reveals a sense attitudes are changing, with a number of issues in the post-crisis years demonstrating the importance of having the function embedded within the firm.

Lord Devlin in the Wolfenden Committee argued that the law should serve a normative function in excluding social changes that are yet to become dominant public norms as perceived by society at large.

This uses a whole rewritten expression evaluation engine (introduced in v10), and a large number of infrastructure changes all over the executor (reimplementation of targetlist set returning functions, projection,...).

Janice worked for Accenture in South Africa, heading up their Recruitment function for 5 years before joining Investec as their Head of Talent, where she led a large change project for the recruitment function.

It went something like this: hotel check - in, locate room, locate wifi service, attempt connection to wifi, wonder why the connection is taking so long, try again, locate phone, call front desk, get told «the internet is broken for a while», decide to hot - spot the mobile phone because some emails really needed to be sent, go «la la la» about the roaming costs, locate iron, wonder why iron temperature dial just spins around and around, swear as iron spews water instead of steam, find reading glasses, curse middle - aged need for reading glasses, realise iron temperature dial is indecipherably in Chinese, decide ironing front of shirt is good enough when wearing jacket, order room service lunch, start shower, realise can't read impossible small toiletry bottle labels, damply retrieve glasses from near iron and successfully avoid shampooing hair with body lotion, change (into slightly damp shirt), retrieve glasses from shower, start teleconference, eat lunch, remember to mute phone, meet colleague in lobby at 1 pm, continue teleconference, get in taxi, endure 75 stop - start minutes to a inconveniently located client, watch unread emails climb over 150, continue to ignore roaming costs, regret tuna panini lunch choice as taxi warmth, stop - start juddering, jet - lag, guilt about unread emails and traffic fumes combine in a very unpleasant way, stumble out of over-warm taxi and almost catch hypothermia while trying to locate a very small client office in a very large anonymous business park, almost hug client with relief when they appear to escort us the last 50 metres, surprisingly have very positive client meeting (i.e. didn't throw up in the meeting), almost catch hypothermia again waiting for taxi which despite having two functioning GPS devices can't locate us on a main road, understand why as within 30 seconds we are almost rendered unconscious by the in - car exhaust fumes, discover that the taxi ride back to the CBD is even slower and more juddering at peak hour (and no, that was not a carbon monoxide induced hallucination), rescheduled the second client from 5 pm to 5.30, to 6 pm and finally 6.30 pm, killed time by drafting this guest blog (possibly carbon monoxide induced), watch unread emails climb higher, exit taxi and inhale relatively fresher air from kamikaze motor scooters, enter office and grumpily work with client until 9 pm, decline client's gracious offer of expensive dinner, noting it is already midnight my time, observe client fail to correctly set office alarm and endure high decibel «warning, warning» sounds that are clearly designed to send security rushing... soon... any second now... develop new form of nausea and headache from piercing, screeching, sounds - like - a-wailing-baby-please-please-make-it-stop-alarm, note the client is relishing the extra (free) time with us and is still talking about work, admire the client's ability to focus under extreme aural pressure, decide the client may be a little too work focussed, realise that I probably am too given I have just finished work at 9 pm... but then remember the 200 unread emails in my inbox and decide I can resolve that incongruency later (in a quieter space), become sure that there are only two possibilities — there are no security staff or they are deaf — while my colleague frantically tries to call someone who knows what to do, conclude after three calls that no - one does, and then finally someone finally does and... it stops.