Sentences with phrase «large changes in the rate»

No significant imbalance occurs despite large changes in the rate of energy release by the oceans and significant changes in the speed of the hydrological cycle via changes in the air circulation systems.

The other outcome measures are not included due to volatility in measurement (counties with small populations see large changes in their rates) or changes in how the indicator is measured over time (the MAP tests have not remained consistent in the last several years).

Not exact matches

This data shouldn't change the Fed's interest - rate strategy, as a rising labor force participation rate will put a lid on inflation regardless of how it's done, but it should lower our confidence that the Fed can solve the problem of a bifurcated workforce, in which a large chunk of workers are getting left behind, simply through interest rate policy.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

A number of operational features were required to implement such an overnight reverse repo, or ON RRP, facility: It would need same - day settlement; 16 the operation would need to be run predictably, every day, and as late in the day as possible, to give lenders time to bargain with other counterparties using the outside option of investing with the Federal Reserve; 17 an appropriate spread below IOR would be required to ensure that the facility neither induced large changes in the structure of money markets nor lost the ability to support interest rate control; 18 and the operations would need enough unused capacity that lenders could credibly propose to leave borrowers that did not offer an adequate interest rate.19

Changes in the interest rate environment have had a very large impact on bond returns over the long run.

But a prolonged continuation of the exchange rate arrangements that have given rise to the large increase in foreign official investments in U.S. financial assets is unlikely to be consistent with the domestic requirements of those economies, and for this reason many are already in the process of change.

Expectations of more persistent changes in the cash rate will have larger effects.

Since a larger share of deposit rates are fixed than are loan rates, this will overstate the effect on cash flows over longer time horizons, though the extent of this bias has not necessarily changed over time in an obvious way.

Since changes in interest rates impact bond funds differently than bonds and CDs, estimates of price sensitivity may be less accurate the larger the shift in interest rates.

The legislative restriction on annual changes in premium rates has led to the current large cumulative deficits and once these are unraveled (by 2015), they will lead to large cumulative surpluses.

Due to the large and expanding scale of our international business activities, any changes in the U.S. or foreign taxation of such activities may increase our worldwide effective tax rate and the amount of taxes we pay and seriously harm our business.

This was supported by findings in the Equality and Human Rights Commission report in 2008 which said that at the current rate of change, it would take more than 70 years to achieve a gender balance in the boardrooms in the UK's largest 100 companies.

Due to potentially - large oscillations in the desire to hold cash and to the fact that changes in the money supply can take years to impact the cost of living, this theoretical rate of purchasing - power change will tend to be inaccurate over periods of two years or less but should approximate the actual rate of purchasing - power change over periods of five years or more.

I just noticed that the 30 - yr mortgage rate at Wells Fargo — 2nd largest mortgage lender — has not changed much in the last few weeks despite the decline in the 10 yr yield.

Changes in the larger world - system are likely to consist of shifts in overall rates of economic growth, changes that reverberate from the rise and fall of great powers, alterations in international relations, variations in uncertainty and conflict, and even modifications of the extent to which people are aware of these larger relChanges in the larger world - system are likely to consist of shifts in overall rates of economic growth, changes that reverberate from the rise and fall of great powers, alterations in international relations, variations in uncertainty and conflict, and even modifications of the extent to which people are aware of these larger relchanges that reverberate from the rise and fall of great powers, alterations in international relations, variations in uncertainty and conflict, and even modifications of the extent to which people are aware of these larger relations.

This is one of the top rated diaper changing pads accompanied by 25 large - sized bags in order to dispose used nappies.

Dana has intimate familiarity with what it takes to make significant changes in a large, urban district like my own, and she is less - than - starry - eyed about the ability of any other district to follow suit without outside funding — over and above the current USDA reimbursement rate, OR that amount plus six cents.

Finally, in so doing, both the EU and China would put further pressure on the US, which, even though it has the highest per / capita emissions rate among the world's largest economies, it is still reticent to commit to fight climate change.

In order to make the plan amenable for Senate Republicans, it is likely the tax cut would be a large one, making a rate change on the rich significant.

The changes in debt between 2010 and present are marginal though (only $ 2.4 trillion), does that make a large enough dent in the additional interest payments when the rate was much higher (before the 2007 crash)?

Even though the actual rate of global warming far exceeds that of any previous episodes in the past 14,000 years, large changes in global climate have occurred periodically throughout Earth's history.

«I re-examined fossil calibrations, excluding those that were contentious or based on poorly resolved fossil placements and also fossil calibrations from within groups of very large or long - lived mammals, such as whales, for which parallel changes in the rate of DNA evolution in different lineages could distort dating estimates.

The simulations suggest that, for greenhouse gas emissions at or above current rates, changes in climate will very likely be larger than the changes already observed during the 20th century.

For example, he says, although the new study found no overall change in the rate of melting at Totten Glacier over the last couple of decades, the large variability in melting rate within those decades warrants a much closer look at the region's complex topography, among other factors, in order to anticipate how the system could actually change in the future.

The function of these genes were involved in molecular maintenance strategies, such as DNA repair, chromosomal maintenance, immune response and programmed cell death The authors argue that the «slower rate of change in these functions is consistent with increased constraint on somatic cell maintenance as would be required in these relatively long - lived and large - bodied mammals, illustrated by the additional large and long - lived species with slower rates in these genes (e.g. double - strand break repair gene XRCC4 is also highly constrained in elephant.»

This is the largest cohort study to analyze changes in rates of pre-eclampsia in the U.S.

Moreover, a jump in the region's erosion rates about a million years ago coincides with a transition to more powerful ice ages — a sign that climate change can have a larger than expected effect in tearing down mountains.

In contrast, rapid environmental change may slow the overall rate of evolution driven by direct interactions within large networks, making each species more vulnerable to extinction.

Scientists have long known that small changes in Earth's water cycle could lead to large, although temporary, changes in the rate of sea level rise.

IIRC, the authors were perturbed by the fact that small changes in the input - value mix of the model produced large differences in the rate of climate change.

We examined changes in tree growth rates over the past two decades for all species occurring in large (50 - ha) forest dynamics plots in Panama and Malaysia.

Amrein and Berliner's solution was just to toss these states out, no matter how small the change in exclusion rate or how large the change in achievement.

Changes in judicial policies, particularly those related to drug offenses, have led to a large increase in the incarceration rate of minority males.

Bob Delaporte, an aide to Joint Finance Committee co-chairwoman Sen. Alberta Darling, R - River Hills, said the intent behind the proposal is «to leverage change in large urban school districts with systemic rates of failure.»

The changes are likely to lower the passing rates significantly all over the state, particularly in districts and schools in large urban cities.

This would mean a change of 84 percentage points in the population that is African American, for example, which is larger than the average difference between the most in - boundary neighborhoods with the highest boundary participation rates and others.

The results have been promising: A study of statewide implementation of the 5Essentials across Illinois — a state that encompasses districts of diverse size and composition — found that strength on the five essential supports is positively related to higher test scores and larger gains over time in math and reading, positive changes in attendance rates, and improved graduation rates.

Not only do the data show a clear change before and after Act 10 passed, but changes in compensation, turnover, and exit rates appear to be larger in Wisconsin than in other states.6 Further, both supporters and opponents of the law agree that it caused major cuts to teacher benefits and reduced teachers» compensation.

The nation's largest airlines reported only one flight in August with a tarmac delay of more than three hours, compared to 66 flights in August 2009, with no change in the rate of canceled flights, according to the Air Travel Consumer Report released today by the U.S. Department of Transportation (DOT).

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The Dynocom DC - 1250 has several product changes, including an increase in the shaft sizes, from 1.25 - to 1.5 - inch; the addition of a larger eddy brake rated at 700 hp (instead of 600 hp); X-Cut knurling; and integrated tie down electronic anchoring indication.

The Dynocom DC - 1250 has several product changes, including an increase in the shaft sizes, from 1.25» to 1.5»; the addition of a larger eddy brake rated at 700 hp (instead of 600 hp); X-Cut knurling; and integrated tie down electronic anchoring indication.

It's about digital change and what it does to large and small markets, especially when the rates of change in these markets differ.

The camera area of the Galaxy S7 Edge was changed quite a bit this year — gone is the highly rated 16MP shooter from the S6 models and instead, there is a new Dual Pixel 12MP with a larger sensor, allowing it to take in more light and information than the smaller 16MP sensor.

Such statements reflect the current views of Barnes & Noble with respect to future events, the outcome of which is subject to certain risks, including, among others, the general economic environment and consumer spending patterns, decreased consumer demand for Barnes & Noble's products, low growth or declining sales and net income due to various factors, possible disruptions in Barnes & Noble's computer systems, telephone systems or supply chain, possible risks associated with data privacy, information security and intellectual property, possible work stoppages or increases in labor costs, possible increases in shipping rates or interruptions in shipping service, effects of competition, possible risks that inventory in channels of distribution may be larger than able to be sold, possible risks associated with changes in the strategic direction of the device business, including possible reduction in sales of content, accessories and other merchandise and other adverse financial impacts, possible risk that component parts will be rendered obsolete or otherwise not be able to be effectively utilized in devices to be sold, possible risk that financial and operational forecasts and projections are not achieved, possible risk that returns from consumers or channels of distribution may be greater than estimated, the risk that digital sales growth is less than expectations and the risk that it does not exceed the rate of investment spend, higher - than - anticipated store closing or relocation costs, higher interest rates, the performance of Barnes & Noble's online, digital and other initiatives, the success of Barnes & Noble's strategic investments, unanticipated increases in merchandise, component or occupancy costs, unanticipated adverse litigation results or effects, product and component shortages, the potential adverse impact on the Company's businesses resulting from the Company's prior reviews of strategic alternatives and the potential separation of the Company's businesses, the risk that the transactions with Microsoft and Pearson do not achieve the expected benefits for the parties or impose costs on the Company in excess of what the Company anticipates, including the risk that NOOK Media's applications are not commercially successful or that the expected distribution of those applications is not achieved, risks associated with the international expansion contemplated by the relationship with Microsoft, including that it is not successful or is delayed, the risk that NOOK Media is not able to perform its obligations under the Microsoft and Pearson commercial agreements and the consequences thereof, risks associated with the restatement contained in, the delayed filing of, and the material weakness in internal controls described in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended April 27, 2013, risks associated with the SEC investigation disclosed in the quarterly report on Form 10 - Q for the fiscal quarter ended October 26, 2013, risks associated with the ongoing efforts to rationalize the NOOK business and the expected costs and benefits of such efforts and associated risks and other factors which may be outside of Barnes & Noble's control, including those factors discussed in detail in Item 1A, «Risk Factors,» in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended April 27, 2013, and in Barnes & Noble's other filings made hereafter from time to time with the SEC.

Such statements reflect the current views of Barnes & Noble with respect to future events, the outcome of which is subject to certain risks, including, among others, the effect of the proposed separation of NOOK Media, the general economic environment and consumer spending patterns, decreased consumer demand for Barnes & Noble's products, low growth or declining sales and net income due to various factors, possible disruptions in Barnes & Noble's computer systems, telephone systems or supply chain, possible risks associated with data privacy, information security and intellectual property, possible work stoppages or increases in labor costs, possible increases in shipping rates or interruptions in shipping service, effects of competition, possible risks that inventory in channels of distribution may be larger than able to be sold, possible risks associated with changes in the strategic direction of the device business, including possible reduction in sales of content, accessories and other merchandise and other adverse financial impacts, possible risk that component parts will be rendered obsolete or otherwise not be able to be effectively utilized in devices to be sold, possible risk that financial and operational forecasts and projections are not achieved, possible risk that returns from consumers or channels of distribution may be greater than estimated, the risk that digital sales growth is less than expectations and the risk that it does not exceed the rate of investment spend, higher - than - anticipated store closing or relocation costs, higher interest rates, the performance of Barnes & Noble's online, digital and other initiatives, the success of Barnes & Noble's strategic investments, unanticipated increases in merchandise, component or occupancy costs, unanticipated adverse litigation results or effects, product and component shortages, risks associated with the commercial agreement with Samsung, the potential adverse impact on the Company's businesses resulting from the Company's prior reviews of strategic alternatives and the potential separation of the Company's businesses (including with respect to the timing of the completion thereof), the risk that the transactions with Pearson and Samsung do not achieve the expected benefits for the parties or impose costs on the Company in excess of what the Company anticipates, including the risk that NOOK Media's applications are not commercially successful or that the expected distribution of those applications is not achieved, risks associated with the international expansion previously undertaken, including any risks associated with a reduction of international operations following termination of the Microsoft commercial agreement, the risk that NOOK Media is not able to perform its obligations under the Pearson and Samsung commercial agreements and the consequences thereof, the risks associated with the termination of Microsoft commercial agreement, including potential customer losses, risks associated with the restatement contained in, the delayed filing of, and the material weakness in internal controls described in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended April 27, 2013, risks associated with the SEC investigation disclosed in the quarterly report on Form 10 - Q for the fiscal quarter ended October 26, 2013, risks associated with the ongoing efforts to rationalize the NOOK business and the expected costs and benefits of such efforts and associated risks and other factors which may be outside of Barnes & Noble's control, including those factors discussed in detail in Item 1A, «Risk Factors,» in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended May 3, 2014, and in Barnes & Noble's other filings made hereafter from time to time with the SEC.

We've established that to a large extent, both liquidity preference and short - term interest rates respond fairly passively to changes in the monetary base.

TIPS really protect against large inflation changes as normal bonds have the future expected inflation already baked in their higher rates.

You have probably heard about some of the major changes that take effect beginning in 2018 — a big cut to the corporate tax rate, lower marginal rates across the board, and a larger standard deduction.