And Roosevelt probably would have advocated caution in making
large changes to the environment that we don't fully understand.
Not exact matches
These risks and uncertainties include: Gilead's ability
to achieve its anticipated full year 2018 financial results; Gilead's ability
to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant
to provide, or continue
to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due
to ongoing contracts and future negotiations with commercial and government payers; a
larger than anticipated shift in payer mix
to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic
environment; and potential amendments
to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability
to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability
to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability
to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability
to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability
to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant
to prescribe the products; Gilead's ability
to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability
to pay dividends or complete its share repurchase program due
to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time
to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
Kesem is the
largest national organization dedicated
to this unique population, and for many children their Camp Kesem experience is a life -
changing event — providing them a community of children with similar experiences, and a safe and welcoming
environment to have fun and rediscover their childhood.
This situation has created fear and panic among the Ghanaian work force and
to a
large extent limiting the free friendly worker
environment that existed before the
change of government on 7th January, 2017.
A new nationwide project aims
to monitor the
environment of the U.S. and enable comparisons of
large - scale problems and variables such as climate
change, pollution and sprawl
The effect also illustrates one proposal for so - called geoengineering — the deliberate,
large - scale manipulation of the planetary
environment — that would use various means
to create such sulfuric acid aerosols in the stratosphere
to reflect sunlight and thereby hopefully forestall catastrophic climate
change.
Hunt and his colleagues drew on
large collections of ostracod fossils from the Smithsonian's National Museum of Natural History, the University of Southern Mississippi, and Louisiana State University, as well as additional fossils they collected themselves,
to investigate whether species in which this male / female distinction was most prominent had been more vulnerable than others
to changes in their
environments.
To better understand these effects, this study, funded by the UK Natural
Environment Research Council and the UK Department of Energy and Climate
Change, examined a natural reservoir where
large natural pockets of CO2 have been trapped in sedimentary rocks for hundreds of thousands of years.
Short of passing a new tax or making
larger changes to the eating
environment, is there information that might be more effective than just the calorie counts?
Given the
large number of water users, the growing demand for water resources, the variety of stakeholders involved and the increasing intensity of climate
change impacts, collective action and shared solutions are needed
to alleviate the pressure on the
environment, business and communities.
The team, headed by Loma Linda University (LLU) researcher Helen Harwatt, PhD, suggests that one simple
change in American eating habits would have a
large impact on the
environment: if Americans would eat beans instead of beef, the United States would immediately realize approximately 50
to 75 percent of its GHG reduction targets for the year 2020.
Walking along the beaches of New England, it is easy
to spot
large amounts of a fine red seaweed clogging the coastline, the result of sweeping
changes in the marine
environment occurring beneath the water.
Like rodents, cephalopods are highly adaptable
to changes in their
environment, researchers say — in
large part because most species live just 1 or 2 years, dying as soon as they give birth.
Larger - scale
changes to make healthy choices easy choices in children's everyday
environments can help caregivers
to use recommended strategies
to increase acceptance of healthier foods successfully.
The fact that Neanderthals — typically associated with hunting
large prey over short distances in woodland settings — were seemingly unable
to catch and kill such creatures is compounded by rapid
changes in the
environment.
«It's intuitive that taking a vacation reduces biological processes related
to stress, but it was still impressive
to see the
large changes in gene expression from being away from the busy pace of life, in a relaxing
environment, in such a short period of time.
Such language stems from a
changing environment, mainly connected
to the growing cost of related projects, with a corresponding need for
large numbers of international funding partners.
Phytoplankton are tiny organisms that are critical in offsetting climate
change because they undergo a process called photosynthesis, whereby they absorb
large enough amounts of heat - trapping carbon dioxide
to cool Earth's warming
environment while releasing much of oxygen we breathe.
New and even beneficial mutations are diluted by the population's
large size and are unable
to reach fixation, due
to such factors as constantly
changing environments.
In turning
to a methodological issue, the new archaeological horizons in the Monte Verde area are difficult
to trace laterally over areas
larger than ~ 8 — 10 m2 and probably represent only fragments of a broader landscape utilized by people adapting
to changing climates and
environments in the area.
The best New Year's Resolutions pave the way for
larger goals, such as more balance, more simplicity, and more presence; making healthier
changes to our home
environments is a great start
to achieving those objectives.
No other human beings on the planet get
to really see the amazing
changes on such a
large scale unless they are working in an
environment that practices a whole food plant based diet as there first line of medicine.
The
change to having a much
larger connected
environment helps World feel way more alive and adds a great sense of scale
to the adventure, such as when you're tracking down a Great Jagras only
to have a Bazelgeuse invade from the sky and mess up everyone's day (which has happened on more than one occasion in High Rank).
The dynamics of the spread of infection is fluid and responds
to the
changes in the
larger environment.
Through Connections School's emphasis on peace issues and non-violent conflict resolution, teachers not only hope
to foster a safer school
environment, but also create
change agents
to send into a troubled Chicago neighborhood and the
larger community.
While our analysis indicates that ability grouping and DI occur simultaneously, there is still much
to learn about how teachers make meaning of these practices and the extent
to which
changes in the
larger institutional
environment inform their decisions.
Such statements reflect the current views of Barnes & Noble with respect
to future events, the outcome of which is subject
to certain risks, including, among others, the general economic
environment and consumer spending patterns, decreased consumer demand for Barnes & Noble's products, low growth or declining sales and net income due
to various factors, possible disruptions in Barnes & Noble's computer systems, telephone systems or supply chain, possible risks associated with data privacy, information security and intellectual property, possible work stoppages or increases in labor costs, possible increases in shipping rates or interruptions in shipping service, effects of competition, possible risks that inventory in channels of distribution may be
larger than able
to be sold, possible risks associated with
changes in the strategic direction of the device business, including possible reduction in sales of content, accessories and other merchandise and other adverse financial impacts, possible risk that component parts will be rendered obsolete or otherwise not be able
to be effectively utilized in devices
to be sold, possible risk that financial and operational forecasts and projections are not achieved, possible risk that returns from consumers or channels of distribution may be greater than estimated, the risk that digital sales growth is less than expectations and the risk that it does not exceed the rate of investment spend, higher - than - anticipated store closing or relocation costs, higher interest rates, the performance of Barnes & Noble's online, digital and other initiatives, the success of Barnes & Noble's strategic investments, unanticipated increases in merchandise, component or occupancy costs, unanticipated adverse litigation results or effects, product and component shortages, the potential adverse impact on the Company's businesses resulting from the Company's prior reviews of strategic alternatives and the potential separation of the Company's businesses, the risk that the transactions with Microsoft and Pearson do not achieve the expected benefits for the parties or impose costs on the Company in excess of what the Company anticipates, including the risk that NOOK Media's applications are not commercially successful or that the expected distribution of those applications is not achieved, risks associated with the international expansion contemplated by the relationship with Microsoft, including that it is not successful or is delayed, the risk that NOOK Media is not able
to perform its obligations under the Microsoft and Pearson commercial agreements and the consequences thereof, risks associated with the restatement contained in, the delayed filing of, and the material weakness in internal controls described in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended April 27, 2013, risks associated with the SEC investigation disclosed in the quarterly report on Form 10 - Q for the fiscal quarter ended October 26, 2013, risks associated with the ongoing efforts
to rationalize the NOOK business and the expected costs and benefits of such efforts and associated risks and other factors which may be outside of Barnes & Noble's control, including those factors discussed in detail in Item 1A, «Risk Factors,» in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended April 27, 2013, and in Barnes & Noble's other filings made hereafter from time
to time with the SEC.
Such statements reflect the current views of Barnes & Noble with respect
to future events, the outcome of which is subject
to certain risks, including, among others, the effect of the proposed separation of NOOK Media, the general economic
environment and consumer spending patterns, decreased consumer demand for Barnes & Noble's products, low growth or declining sales and net income due
to various factors, possible disruptions in Barnes & Noble's computer systems, telephone systems or supply chain, possible risks associated with data privacy, information security and intellectual property, possible work stoppages or increases in labor costs, possible increases in shipping rates or interruptions in shipping service, effects of competition, possible risks that inventory in channels of distribution may be
larger than able
to be sold, possible risks associated with
changes in the strategic direction of the device business, including possible reduction in sales of content, accessories and other merchandise and other adverse financial impacts, possible risk that component parts will be rendered obsolete or otherwise not be able
to be effectively utilized in devices
to be sold, possible risk that financial and operational forecasts and projections are not achieved, possible risk that returns from consumers or channels of distribution may be greater than estimated, the risk that digital sales growth is less than expectations and the risk that it does not exceed the rate of investment spend, higher - than - anticipated store closing or relocation costs, higher interest rates, the performance of Barnes & Noble's online, digital and other initiatives, the success of Barnes & Noble's strategic investments, unanticipated increases in merchandise, component or occupancy costs, unanticipated adverse litigation results or effects, product and component shortages, risks associated with the commercial agreement with Samsung, the potential adverse impact on the Company's businesses resulting from the Company's prior reviews of strategic alternatives and the potential separation of the Company's businesses (including with respect
to the timing of the completion thereof), the risk that the transactions with Pearson and Samsung do not achieve the expected benefits for the parties or impose costs on the Company in excess of what the Company anticipates, including the risk that NOOK Media's applications are not commercially successful or that the expected distribution of those applications is not achieved, risks associated with the international expansion previously undertaken, including any risks associated with a reduction of international operations following termination of the Microsoft commercial agreement, the risk that NOOK Media is not able
to perform its obligations under the Pearson and Samsung commercial agreements and the consequences thereof, the risks associated with the termination of Microsoft commercial agreement, including potential customer losses, risks associated with the restatement contained in, the delayed filing of, and the material weakness in internal controls described in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended April 27, 2013, risks associated with the SEC investigation disclosed in the quarterly report on Form 10 - Q for the fiscal quarter ended October 26, 2013, risks associated with the ongoing efforts
to rationalize the NOOK business and the expected costs and benefits of such efforts and associated risks and other factors which may be outside of Barnes & Noble's control, including those factors discussed in detail in Item 1A, «Risk Factors,» in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended May 3, 2014, and in Barnes & Noble's other filings made hereafter from time
to time with the SEC.
To a
large extent, that evolution was necessary given the
changes in the marketplace for mutual funds, as well as the
changes in the regulatory
environment.
In
large part because the legal
environment has
changed: it's much more hostile
to mass tort actions, thanks in
large part
to a conservative majority on the Supreme Court.
Bonds can be traded on the open market and their principal value can fluctuate in
large part due
to changes in the interest rate
environment or in the financial stability of the issuer.
This positive sentiment
change is likely supported by the Canadian banks» performance during the financial crisis, combined with years of a harsh U.S. regulatory
environment, particularly against the
largest banks (in stark contrast
to Canada, which arguably has the most pro-bank regulator globally).
Cats are extremely sensitive, and huge
changes such as moving, a new pet, the loss of a family member, or a
change to their
environment can cause
large amounts of stress and anxiety, leading
to the excessive chewing and tearing of their hair.
Initially
large animal oriented, the practice has adapted
to a
changing environment and become primarily a companion animal practice.
With total assets of $ 11.1 billion * and serving a population
larger than the state of Georgia, Baylor Scott & White Health has the vision and resources
to provide its patients continued quality care while creating a model system for a dramatically
changing health care
environment.
(Kennel Club Press Release) The Kennel Club, the
largest organisation dedicated
to dog welfare in the UK, has welcomed the Department for
Environment, Food and Rural Affairs» (Defra) proposed
changes to the EU Pet Travel Scheme, but remains concerned about their long term effectiveness.
The production of huge biomass quantities in these distinctive soda lakes and the food web that this green algae supports are also of international scientific value, and provide critical support
to birds, which visit the property in
large numbers as part of their migration in response
to seasonal and episodic
changes in the
environment.
The record numbers of stranded marine mammals we've seen in recent years indicates there is an urgent need for more science
to help us all better understand how
large - scale human impacts, such as climate
change, overfishing and pollution, may be affecting the health of these animals and their ocean
environment.
- the team has been adding weapons one by one because they want the same amount of attention for each weapon - the team learned that when they added two new weapons at once, one would end up getting overshadowed by the other - there were more new stages than returning stages because bringing back old stages would have little surprise - since they want
to satisfy both new and returning players, they
changed the order of stage additions - there weren't any major direction
changes in balancing from Splatoon 1 - there have been more pattern combinations between weapons and stages, so there was more involved
to balance them all - matchmaking is handled by getting 8 players with similar rank points, and then they're split by weapons - the rank point gap between S + players is bigger than ordinary players - only about one in 1,000 active players are in the S +40
to S +50 region in Ranked Battles - there's even less than one in 10 players that reach S +, while 80 % of the overall player base are in A or less - about 90 % of S + ranked players are within a + / -150 hidden ranked power range - rock was the popular genre in Splatoon, so they tried
changing it for the sequel - they prioritized making good background music first before forming the band
to play that music - the design team would make the CD jacket - like artwork afterwards - due
to this, the band members would often
change; some getting added while some others removed - Off the Hook is an exception, as they first decided they would be a DJ and rapper along with their visuals first - Off the Hook's song came afterwards - In Splatoon street fashion was the trend, but in Splatoon 2 they tried adding more uniqueness - the aim was
to add Flow with ethnic clothing and Jelfonzo with high fashion - all Jellyfish in this world are born by splitting, which means Jelfonzo was born by splitting from Jelonzo - Jellyfish are like a hive mind - when they hold a wedding ceremony, they're just simply holding the ceremony - Jelonzo and Jelfonzo start gaining their own consciences so they can speak - Flow used her working holiday
to go on a trip before reaching Inkopolis Square - during the trip, she met the owner of Headspace - the owner liked her, so she got hired
to work there - Bisk has a unique way of speaking: anastrophe - the team tried
to express him as an adult man - they made him into a giant spider crab because they wanted someone with high posture - he came from a cold country and broke up with his girlfriend
to join a band - just like Flow, he became attracted
to squids - Crusty Sean finally has his own shop, but he opened it because he's someone who follows the current trends - one of the trends happens
to be people opening their own shops - drink tickets aren't stacked, but the probability is higher than a single brand - the music in Inkopolis Square
changes depending on the player's location - sounds contribute
to creating atmosphere in the location - the song at front of Grizzco Industries had an atmosphere that feels like some smell can radiate from the game screen - as for Salmon Run, they imagined it as a Japanese restaurant outside Japan that is not run by a Japanese person - each time the player moves between the shops, the game uses an arrange shift that shows the personality of each inhabitant - the arrangement in Shella Fresh is related
to Bisk's guitar and mystery files that describe his past - with the Squid Sisters moved
to Hero Mode, Off the Hook was put in charge in guiding battles and festivals - Bomb Rush Blush has an orchestra «because it would sound like the final boss» - the team wanted
to express the feel of the story's real culprit with this music - the probability of each event occurring in Salmon Run is different - there are no specific requirements, meaning they're picked randomly - this means it's possible for fog
to appear three times in a row - the Salmon have different appearances based on the
environment they're raised in - if the
environment is harsher, they would become
large salmon - Steelheads and Maws have big bodies, while Scrappers and Steel Eels have high intelligence - Salmons basically wield kitchenware, but everybody else has a virtue in fighting
to actually cook the Salmons - Grill is the ultimate form of this - when Salmons are fighting
to the death, they can feel the same sense of unity - they would be one with the world if they were eaten by other creatures, and they also fight for the pride of their race - MakoMart is based on a
large supermarket in America - the update also took place on Black Friday in America, which was why Squids are buying a lot of things in the trailer - Arowana Mall looks like it has more passages because there are
changes in tenants and also renovation work - Walleye Warehouse has no
changes at all, because the team wanted
to have at least one map that stayed intact - the only thing different in this map is the graffiti, which is based on the winner of Famitsu's Squid Fashion Contest - all members in the band Ink Theory graduated from music university - they are well - educated girls who also do aggressive things - the band members wearing neckties are respecting the Hightide Era from the prequel - the team will continue adding weapons and stages for a year, and Splatfests for two years - the team will also continue
to make more updates including balancing
The addition of voice acting and a
large open
environment to explore
change - up the game just enough
to help it feel fresh and different from the other titles in the series whilst retaining the fun, charm and addictive gameplay.
Large - Scale, Site - Specific Installation Explores the Ever -
Changing Natural
Environment of the City of New Orleans Katie Holten: Drawn
to the Edge On View June 15 - September 9, 2012 New Orleans, LA — For the second annual installment of the Great Hall Project series at the New Orleans Museum of Art, artist Katie Holten will map the... Read More
The ROM is the
largest field research institution in the country, and a world leader in research areas from biodiversity, palaeontology, and earth sciences
to archaeology, ethnology and visual culture - originating new information towards a global understanding of historical and modern
change in culture and
environment.
The experimentation blossomed into a lifelong obsession that would culminate in his best - known series of paintings, Homage
to the Square, in which he painted several differently - colored squares within
larger squares in order
to illustrate his theory that alterations in
environment, shape and light would produce
changes in color.
With the 1969 exhibition Für Veränderungen aller Art (For
Changes of All Kinds), he created an artistic test bed for
large - scale
environments produced as collective works by young artists,
to be experienced in a performative fashion.
They describe research showing that the quantity of ragweed pollen produced in doubled CO2
environments is increased significantly (61 percent), not because of
large increases in size (~ 10 percent) but rather (apparently) due
to a
changing internal allocation of resources.
I'm pretty fascinated by the advent of research and discussion of this new technology, which of course «refers
to deliberate,
large - scale manipulations of Earth's
environment designed
to offset some of the harmful consequences of [greenhouse - gas induced] climate
change.»
In a similar argument, Katharina Nett and Lukas Rüttinger in a report for adelphi asserted last month that «
large - scale environmental and climatic
change contributes
to creating an
environment in which [non-state armed groups] can thrive and opens spaces that facilitate the pursuit of their strategies.»
The United Nations has called climate
change «the
largest, most pervasive threat
to the natural
environment and human rights of our time.»
Members of the public have «a negative view» of deliberate
large - scale manipulation of the
environment to counteract climate
change, according to new research in Nature Climate C
change, according
to new research in Nature Climate
ChangeChange.
I am a big believer in creating a cleaner
environment for our future generations but have never felt that climate
change was the
largest threat
to humanity like some politicians like
to tell us constantly.