Sentences with phrase «large changes we are seeing»

Given the large changes we are seeing in the ice sheets today, that's not likely.»

Not exact matches

China is stuck in the middle as it is a traditional ally of North Korea, is its largest trading partner and would not like to see regime change in North Korea.

With America's second largest consumer group changing their real estate choices it remains to be see how the housing industry will adapt.

The two were also agreed that larger national discussions need to be held around climate change, economic development and accommodation of aboriginal rights and title — and that LNG development should be seen as an opportunity to move on these issues.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

We'll see if my asset allocation model changes once larger $ amounts are involved and I have more time on my hands after I reach financial independence.

That's a staggering number considering all of the changes and unknowns that still exist with one of the largest changes to health care our country has ever seen.

However, the company is clear that none of the many changes it is seeing are slowing down its timeline for moving to its large - format Series 6.

I think the biggest danger, or the biggest thing I see at here was from the SEO or SEM community at large is feeling like somehow, this is such a huge change, that there is this fear that suddenly search engine optimization doesn't matter, that suddenly it's obsolete.

«Given the large numbers at play, it is going to take meaningful time to see big numbers in terms of board diversity percentages but the pace of change is accelerating,» said Cassidy, whose Boardlist now has nearly 4,000 members.

There are a large and increasing number of loan options available to business owners, and we expect to see even more changes and new players in the coming years.

But here the thing: We don't yet currently know, conclusively, that the storms we saw were made larger and nastier by climate change.

Drew Hart is the author of Trouble I've Seen: Changing the Way the Church Views Racism, which released in January and which tackles police brutality, mass incarceration, antiblack stereotypes, poverty, and everyday acts of racism by placing them in the larger framework of white supremacy.

They see that in the United States the broadcast and print media have increasingly turned viewers and readers into a product to be delivered to the the sponsors, so that the objective of news has changed from informing, enlightening and entertaining simply to reaching and holding the largest audience regardless of the damage done to other journalistic objectives.

Things are changing and someday may we all see that we are part of one large family.

Also there is evidence of molecular mechanisms in the cell membranes that can amplify small changes in the field to produce large changes in neural activity.13 On the other hand, earlier tests of Kohler's theory found that interference with electrical gradients over the cortex had no effect on behavioral measures (see note 11 for reference to these studies).

I asked a business director at a large evangelical church in Pittsburgh about changes they were making, and he said, «We don't see other churches as our competition.

Phillipe's father could see changes coming, in which the traditional butcher shops were swallowed up by larger grocery store meat departments.

Celeste works with communities who are tired of corporate control of food and want to see real changes from America's largest meat company.

As you see, food waste is the largest waste stream going to landfills in the US, accounting for 21 percent of the American waste stream and contributing to climate change as food waste in landfills decomposes and generates methane, a very powerful greenhouse gas.

either way I seriously suspect we will be linked with a large number of players and the only one we will see in an Arsenal shirt come august will be Granit We nger has NOT changed in anyway and has already stated that Giroud will lead the line next season which rules out Lewondowski, Aubamayang, Higauin and any real top signings and IF France win the euro (wich will be no real indication of anything much) Wenger will sing Giroud priases to the heavens and state that we have the top striker in europe.

I have personally avoided any spending on AFC while we have been lacking, this has been for MANY years now and I was tempted when we started to spend larger amounts but I waited to see if it was a true change or PR... So I ended up sticking to my own personal avoid giving Silent Stan any money.

This is an incredibly difficult question to answer for a variety of reasons, most importantly because over the years our once vaunted «beautiful» style of play has become a shadow of it's former self, only to be replaced by a less than stellar «plug and play» mentality where players play out of position and adjustments / substitutions are rarely forthcoming before the 75th minute... if you look at our current players, very few would make sense in the traditional Wengerian system... at present, we don't have the personnel to move the ball quickly from deep - lying position, efficient one touch midfielders that can make the necessary through balls or the disciplined and pacey forwards to stretch defences into wide positions, without the aid of the backs coming up into the final 3rd, so that we can attack the defensive lanes in the same clinical fashion we did years ago... on this current squad, we have only 1 central defender on staf, Mustafi, who seems to have any prowess in the offensive zone or who can even pass two zones through so that we can advance play quickly out of our own end (I have seen some inklings that suggest Holding might have some offensive qualities but too early to tell)... unfortunately Mustafi has a tendency to get himself in trouble when he gets overly aggressive on the ball... from our backs out wide, we've seen pace from the likes of Bellerin and Gibbs and the spirited albeit offensively stunted play of Monreal, but none of these players possess the skill - set required in the offensive zone for the new Wenger scheme which requires deft touches, timely runs to the baseline and consistent crossing, especially when Giroud was playing and his ratio of scored goals per clear chances was relatively low (better last year though)... obviously I like Bellerin's future prospects, as you can't teach pace, but I do worry that he regressed last season, which was obvious to Wenger because there was no way he would have used Ox as the right side wing - back so often knowing that Barcelona could come calling in the off - season, if he thought otherwise... as for our midfielders, not a single one, minus the more confident Xhaka I watched played for the Swiss national team a couple years ago, who truly makes sense under the traditional Wenger model... Ramsey holds onto the ball too long, gives the ball away cheaply far too often and abandons his defensive responsibilities on a regular basis (doesn't score enough recently to justify): that being said, I've always thought he does possess a little something special, unfortunately he thinks so too... Xhaka is a little too slow to ever boss the midfield and he tends to telegraph his one true strength, his long ball play: although I must admit he did get a bit better during some points in the latter part of last season... it always made me wonder why whenever he played with Coq Wenger always seemed to play Francis in a more advanced role on the pitch... as for Coq, he is way too reckless at the wrong times and has exhibited little offensive prowess yet finds himself in and around the box far too often... let's face it Wenger was ready to throw him in the trash heap when injuries forced him to use Francis and then he had the nerve to act like this was all part of a bigger Wenger constructed plan... he like Ramsey, Xhaka and Elneny don't offer the skills necessary to satisfy the quick transitory nature of our old offensive scheme or the stout defensive mindset needed to protect the defensive zone so that our offensive players can remain aggressive in the final third... on the front end, we have Ozil, a player of immense skill but stunted by his physical demeanor that tends to offend, the fact that he's been played out of position far too many times since arriving and that the players in front of him, minus Sanchez, make little to no sense considering what he has to offer (especially Giroud); just think about the quick counter-attack offence in Real or the space and protection he receives in the German National team's midfield, where teams couldn't afford to focus too heavily on one individual... this player was a passing «specialist» long before he arrived in North London, so only an arrogant or ignorant individual would try to reinvent the wheel and / or not surround such a talent with the necessary components... in regards to Ox, Walcott and Welbeck, although they all possess serious talents I see them in large part as headless chickens who are on the injury table too much, lack the necessary first - touch and / or lack the finishing flair to warrant their inclusion in a regular starting eleven; I would say that, of the 3, Ox showed the most upside once we went to a back 3, but even he became a bit too consumed by his pending contract talks before the season ended and that concerned me a bit... if I had to choose one of those 3 players to stay on it would be Ox due to his potential as a plausible alternative to Bellerin in that wing - back position should we continue to use that formation... in Sanchez, we get one of the most committed skill players we've seen on this squad for some years but that could all change soon, if it hasn't already of course... strangely enough, even he doesn't make sense given the constructs of the original Wenger offensive model because he holds onto the ball too long and he will give the ball up a little too often in the offensive zone... a fact that is largely forgotten due to his infectious energy and the fact that the numbers he has achieved seem to justify the means... finally, and in many ways most crucially, Giroud, there is nothing about this team or the offensive system that Wenger has traditionally employed that would even suggest such a player would make sense as a starter... too slow, too inefficient and way too easily dispossessed... once again, I think he has some special skills and, at times, has showed some world - class qualities but he's lack of mobility is an albatross around the necks of our offence... so when you ask who would be our best starting 11, I don't have a clue because of the 5 or 6 players that truly deserve a place in this side, 1 just arrived, 3 aren't under contract beyond 2018 and the other was just sold to Juve... man, this is theraputic because following this team is like an addiction to heroin without the benefits

It would not be the first time that Arsenal did this and after seeing it time and time again, including last season, a large number of Arsenal fans were convinced we needed a change at the top.

With the postseason underway, we typically see a large change in public betting with bettors far more likely to take underdogs than they are during the regular season.

Time for some brutal honesty... this team, as it stands, is in no better position to compete next season than they were 12 months ago, minus the fact that some fans have been easily snowed by the acquisition of Lacazette, the free transfer LB and the release of Sanogo... if you look at the facts carefully you will see a team that still has far more questions than answers... to better show what I mean by this statement I will briefly discuss the current state of affairs on a position - by - position basis... in goal we have 4 potential candidates, but in reality we have only 1 option with any real future and somehow he's the only one we have actively tried to get rid of for years because he and his father were a little too involved on social media and he got caught smoking (funny how people still defend Wiltshire under the same and far worse circumstances)... you would think we would want to keep any goaltender that Juventus had interest in, as they seem to have a pretty good history when it comes to that position... as far as the defenders on our current roster there are only a few individuals whom have the skill and / or youth worthy of our time and / or investment, as such we should get rid of anyone who doesn't meet those simple requirements, which means we should get rid of DeBouchy, Gibbs, Gabriel, Mertz and loan out Chambers to see if last seasons foray with Middlesborough was an anomaly or a prediction of things to come... some fans have lamented wildly about the return of Mertz to the starting lineup due to his FA Cup performance but these sort of pie in the sky meanderings are indicative of what's wrong with this club and it's wishy - washy fan - base... in addition to these moves the club should aggressively pursue the acquisition of dominant and mobile CB to stabilize an all too fragile defensive group that has self - destructed on numerous occasions over the past 5 seasons... moving forward and building on our need to re-establish our once dominant presence throughout the middle of the park we need to target a CDM then do whatever it takes to get that player into the fold without any of the usual nickel and diming we have become famous for (this kind of ruthless haggling has cost us numerous special players and certainly can't help make the player in question feel good about the way their future potential employer feels about them)... in order for us to become dominant again we need to be strong up the middle again from Goalkeeper to CB to DM to ACM to striker, like we did in our most glorious years before and during Wenger's reign... with this in mind, if we want Ozil to be that dominant attacking midfielder we can't keep leaving him exposed to constant ridicule about his lack of defensive prowess and provide him with the proper players in the final third... he was never a good defensive player in Real or with the German National squad and they certainly didn't suffer as a result of his presence on the pitch... as for the rest of the midfield the blame falls squarely in the hands of Wenger and Gazidis, the fact that Ramsey, Ox, Sanchez and even Ozil were allowed to regularly start when none of the aforementioned had more than a year left under contract is criminal for a club of this size and financial might... the fact that we could find money for Walcott and Xhaka, who weren't even guaranteed starters, means that our whole business model needs a complete overhaul... for me it's time to get rid of some serious deadweight, even if it means selling them below what you believe their market value is just to simply right this ship and change the stagnant culture that currently exists... this means saying goodbye to Wiltshire, Elneny, Carzola, Walcott and Ramsey... everyone, minus Elneny, have spent just as much time on the training table as on the field of play, which would be manageable if they weren't so inconsistent from a performance standpoint (excluding Carzola, who is like the recent version of Rosicky — too bad, both will be deeply missed)... in their places we need to bring in some proven performers with no history of injuries... up front, although I do like the possibilities that a player like Lacazette presents, the fact that we had to wait so many years to acquire some true quality at the striker position falls once again squarely at the feet of Wenger... this issue highlights the ultimate scam being perpetrated by this club since the arrival of Kroenke: pretend your a small market club when it comes to making purchases but milk your fans like a big market club when it comes to ticket prices and merchandising... I believe the reason why Wenger hasn't pursued someone of Henry's quality, minus a fairly inexpensive RVP, was that he knew that they would demand players of a similar ilk to be brought on board and that wasn't possible when the business model was that of a «selling» club... does it really make sense that we could only make a cheeky bid for Suarez, or that we couldn't get Higuain over the line when he was being offered up for half the price he eventually went to Juve for, or that we've only paid any interest to strikers who were clearly not going to press their current teams to let them go to Arsenal like Benzema or Cavani... just part of the facade that finally came crashing down when Sanchez finally called their bluff... the fact remains that no one wants to win more than Sanchez, including Wenger, and although I don't agree with everything that he has done off the field, I would much rather have Alexis front and center than a manager who has clearly bought into the Kroenke model in large part due to the fact that his enormous ego suggests that only he could accomplish great things without breaking the bank... unfortunately that isn't possible anymore as the game has changed quite dramatically in the last 15 years, which has left a largely complacent and complicit Wenger on the outside looking in... so don't blame those players who demanded more and were left wanting... don't blame those fans who have tried desperately to raise awareness for several years when cracks began to appear... place the blame at the feet of those who were well aware all along of the potential pitfalls of just such a plan but continued to follow it even when it was no longer a financial necessity, like it ever really was...

The issue is that as a supporter — and more pertinently, as a supporter who has only seen Arsenal football under Wenger, a group that I believe makes up a large part of the club's international fan base — this philosophy has changed.

We rented a car since we were a large party and we needed to go to the grocery store etc., but I don't think its necessary - and if you change your mind - every hotel rents cars at reasonable rates so you can just do it for a day and see what you think.

Gluten free is another section I would love seeing catering for and while there is none yet due to their not believing this is a large enough market, I am pretty sure the market size will help steer some of those changes.

Certainly, he had inherited the former Prime Minister's eagerness for America to be involved in other nations» affairs (something which is anathema to the old left who see that country as a bullish, neo-colonial world policeman), saying to an American who queried what was wrong with U.S. disengagement that it was very concerning because only America has the financial resources and will power to cause large, lasting change in the world.

«As the person who helped write the manifesto I have always thought the referendum is a good idea, since if you are making such a large constitutional change I don't see how you can justify not having a referendum.»

Miliband said: «As the person who helped write the manifesto I have always thought the referendum is a good idea, since if you are making such a large constitutional change I don't see how you can justify not having a referendum... on this issue I am pro-reform.

Well, if the proponents of the change looked at UK election results they would see there are large numbers of seats where the incumbents already receive at least 50 per cent of the votes.

This phenomenon is also seen for other emotive subjects such as climate change and vaccination, where some people reject the scientific consensus despite the large body of evidence supporting it.

What has been called the modern synthesis of the two fields emerged in the 1940s with the idea that the sorts of genetic differences you could observe in populations, right out your window, when compounded and extrapolated over vast periods of time, could account for the large - scale changes we see in the fossil record.

«In many of the specifics of the way people view climate change — for instance, seeing it as a moral issue and understanding that climate change is going to hurt people in developing countries and the world's poor the most — we saw really large shifts.»

Just as I came to see my research as part of a larger scientific ecosystem, today I understand that scientific advancements are just one part of the needed response to climate change.

«We were very curious to see what would happen if we were to change the expression pattern of Pax6 in developing mouse brain to mimic that observed in large - brained animals,» says Fong Kuan Wong, a PhD student in the lab of Wieland Huttner and first author of the study.

Co-author Professor Jonathan Bamber, based at the University of Bristol, and President of the European Geoscience Union (EGU), added: «We are seeing changes in the large - scale circulation patterns, which leads to more frequent sunshine and higher amounts of solar energy reaching the surface of the ice sheet.

Public art displays large enough to be seen from space appeared at 18 locations worldwide in the lead - up to the United Nations climate change talks in Cancún, Mexico.

The research is unique in linking local population changes for multiple bird species to broad - scale climate changes, says Beatrice Van Horne, a wildlife researcher at the U.S. Forest Service in Arlington, Virginia: «Things that happen at a large scale are hard to see because local variance often confuses us.

«My group had been looking at the early mechanical changes associated with liver fibrosis, which progresses to cirrhosis, but then, by collaborating with Vivek, we started to wonder if these large scale changes in the architecture of the liver could have a mechanical basis and if something similar to what is seen in gels might be occurring in the liver.

But if large objects were blocking the star's light, then no color change would be seen.

Analyses show that climate shocks are important drivers of the expansions and contractions seen here, suggesting a large and previously overlooked negative impact of climate change on food production.

The size of the brain's ventricles — cerebrospinal fluid - filled spaces deep within the brain — became progressively larger during the course of treatment, and changes were also seen within the subventricular zone, one of two structures in which new brain cells are generated in adults.

The glaciologist was combing through satellite and GPS data to see what small, local effects could be clouding satellite measurements of larger changes in Earth's gravity from ice loss.

«The people who get lots of grants are by and large brilliant people doing really good work,» says Ross McKinney, chief scientific officer for the Association of American Medical Colleges in Washington, D.C. «We'd really like to see the details because we could change the incentives in ways that are not constructive if we are not careful.»

«We are seeing fish communities change from species that are adapted to large, free - flowing rivers to species that occupy small streams with isolated habitats.»

«I've never seen a large - scale community gathering change its mood like that after getting information delivered and being heard,» he says.

When Lieberman increased the money being offered, he found that accepting a share that was larger but still unfair — say, $ 8 out of $ 23 — was linked not with reward circuitry but with increased activity in the ventrolateral prefrontal cortex and downregulation of the anterior insula, changes often seen during the regulation of negative feelings.