Sentences with phrase «large cohort of patients»

Prevalence of parietal cell antibodies in a large cohort of patients with autoimmune thyroiditis.

The study results, derived from a large cohort of patients with long follow - up time, suggest that the rate of revision septorhinoplasty is low, but certain patient characteristics are associated with higher revision rates.

Conclusions and Relevance The study results, derived from a large cohort of patients with long follow - up time, suggest that the rate of revision septorhinoplasty is low, but certain patient characteristics are associated with higher revision rates.

Conducting a cross-sectional study of a large cohort of patients with different levels of cognitive impairment and different disease stages, the researchers found that the amounts of a TREM2 fragment in the cerebrospinal fluid were highest during early stages characterized by mild cognitive impairment symptoms.

The earlier discovery of mutations in UBQLN2 gene, which causes ALS and ALS / dementia in children and adults, in the Siddique lab led to the screening of the UBQLN family of genes in a large cohort of patients with familial ALS, resulting in the identification of the UBQLN4 mutation.

Khachaturian says a proper test of Roses» findings — using Roses» methods in a larger cohort of patients — has not yet been done.

A phase II basket study is ongoing to determine whether these early results can be confirmed in a much larger cohort of patients.

Adams points out that Cohort A is the first phase II study of an immunotherapy for triple negative breast cancer to be reported and represents the largest cohort of patients with mTNBC treated with immunotherapy to date.

This led to the collection of bone marrow samples from larger cohorts of patients with the Ottawa Hospital Research Institute, as well as those from Western University and Hamilton Health Sciences, for the next steps of investigation.

«The study represents the largest cohort of patients with OACICH to date and reports 2 clinically valuable associations.

Rather we are exploring a third solution where we modify the cells to create universal cell lines that can be transplanted into large cohorts of patients.

Our findings are potentially applicable to early disease detection, and future test development should focus on longitudinal sampling of the microbiota to monitor for changes in microbial diversity in a larger cohort of patients.

Here, we report the largest cohort of patients with HUWE1 variants, consisting of 14 females and 7 males, with 15 different missense variants and one splice site variant.

Not exact matches

While further study of larger patient groups with longer follow - up times is needed for this cohort of prostate cancer patients, this study is pivotal in providing evidence for change in practice.»

To further analyze whether FGFR fusions are present across different types of cancers, the researchers extended their assessment and analyzed data generated from an internal cohort of 322 patients, as well as from a large cohort of 2,053 patients recruited to The Cancer Genome Atlas.

The Chronic Hepatitis Cohort Study is an analysis of records from a large, geographically and racially diverse group of 9,783 patients receiving care at four large U.S. health systems: Henry Ford Health System in Detroit; Kaiser Permanente Northwest in Portland, Oregon; Kaiser Permanente in Honolulu and Geisinger Health System in Danville, Pennsylvania.

By evaluating the molecular changes that occur in large cohorts of ovarian cancer patients, the researchers were able to identify several lncRNAs that are linked to the disease.

Dr. Zhang points out that the unique value of this study derives from the ability to perform longitudinal assessments of cognition in PD patients over a long time period and access to data from a large cohort that began when patients were in the earliest stage of disease.

Dr Matt Hurles, who led the study from the Sanger Institute, said: «This study has the largest cohort of such families in the world, and harnesses the power of the NHS, with 200 clinical geneticists and 4,000 patients.

Unlike other solid tumors, there has been limited progress in understanding the contribution of genetic risk factors to the development of uveal melanoma, researchers say, primarily due to the absence of comprehensive genetic data from patients as the large sample cohorts for this rare cancer type have not been available for research.

Researchers expect the data presented in this study to fuel the formation of large national and international research consortiums to conduct comprehensive, systematic analysis of inherited (germline) genome data in large cohorts of uveal melanoma patients.

Researchers were able to access CSF samples from the deprenyl and tocopherol antioxidative therapy of Parkinsonism (DATATOP) study, which is the largest cohort assembled to date with longitudinal collection of biological fluids and clinical data from PD patients.

«Furthermore, analysis of tumor samples from large cohorts of colorectal cancer patients revealed that activation of the loop is associated with metastasis,» Hermeking reports.

This study represents the largest reported cohort of CRC patients diagnosed in this age range in the U.S.

Researchers believe it is the largest epigenetic study yet for any single cancer type and, importantly, the first to use a large cohort of primary patient tumor tissues instead of cell lines grown in the laboratory.

Our study is one of the largest to explore the efficacy and safety of anti-TNF therapy in a large independent cohort of JDM patients.»

They analyzed a large cohort of human patient samples from the human kidney biobank managed by Susztak and found that the interconversion might also occur in patients with kidney disease and likely contributes to a condition when the kidneys can not remove enough acid from the body.

«Now that spinal stimulation has been successful in four out of four patients, there is evidence to suggest a large cohort of individuals, previously with little realistic hope of any meaningful recovery from spinal cord injury, may benefit from this intervention.»

It is the largest randomized clinical trial of ICD recipients to date, involving a cohort of 2,500 patients worldwide.

The NYGC and its founding member institutions are conducting additional studies involving Watson to help accelerate the discovery of potentially actionable sequence variants in various types of cancer, including an ongoing study that involves DNA and RNA from a larger cohort of glioblastoma patients, and a study of 200 patients with different types of cancer.

The present study was aimed at identifying genetic modifiers modulating AAO in a large cohort of Italian FTD patients.

«This study has the largest cohort of such families in the world, and harnesses the power of the NHS, with 200 clinical geneticists and 4,000 patients.

We have investigated the prevalence of this mutation in large cohort of almost 1000 patients with AML (3).

More recently, in a joint initiative with the BBMRI - LPC project (Biobanking and Biomolecular Resources Research Infrastructure — Large Prospective Cohorts) and the Wellcome Trust Sanger Institute, the CNAG - CRG launched a call to promote the use of sequencing technologies for the identification of novel causative variants and genes and to molecularly diagnose rare disease patients.

BioGenoMEL will be coordinated by the University of Leeds and has already received expressions of interest from 6 research groups with large cohorts of melanoma patients in Spain, Austria, Sweden and the USA.

First observed in B - cell lymphoma, recurrent mutations of epigenetic modifier genes have recently been identified in PTCL - NOS. 9 In the present study, we performed targeted sequencing of the main epigenetic modifier genes in a large cohort of Chinese PTCL - NOS patients.

A 2017 study by Balasubramanian et al described 12 previously unreported patients who were part of the DDD Consortium study (a large - scale intellectual disability cohort based in the UK).

Background In our institute, the first research program on disseminated tumor cells (DTC) detection in the bone marrow of early breast cancer patients was initiated in the late 90's; with about a thousand patients included, we constituted one of the largest cohort ever reported and contributed to the landmark report that established bone marrow DTC as a level - of - evidence 1 prognostic factor in early breast cancer (Braun, N Engl J Med 2005).

Analysis of larger cohorts will provide information about the frequency and kinetics of PARPi reversion mutations in this patient population.

Design: We collected standardised PSC subphenotypes in a large cohort of 3402 patients with PSC.

In five independent large cohorts in which more than 1100 total patients were followed for overall survival (Desmedt et al., 2007; Esserman et al., 2012; Kao et al., 2011; Pawitan et al., 2005; van de Vijver et al., 2002; Supplementary file 1), high expression level of MELK strongly correlated with increased rates of mortality (all p values < 0.05, hazard ratios > 2)(Figure 2D, Figure 2 — figure supplement 1D).

-- Towards large - cohort comparative studies to define the factors influencing the gut microbial community structure of ASD patients

Each of the five items was rated on a nine - point scale ranging from 0 (not at all a problem) to 8 (severely impaired) so that the total scores range between 0 and 40.22 The psychometric properties have been validated in large patient with CFS cohorts confirming that WSAS is a reliable assessment tool for disability.