Sentences with phrase «large cohort studies with»

Of two large cohort studies with > 35,000 participants (3,4), Sluijs et al. (3) did not observe a significant association for total protein after adjustment for BMI and waist circumference in the Dutch cohort of European Prospective Investigation into Cancer and Nutrition (EPIC)- InterAct.

Not exact matches

Most studies of homebirth in other countries have found no statistically significant differences in perinatal outcomes between home and hospital births for women at low risk of complications.36, 37,39 However, a recent study in the United States showed poorer neonatal outcomes for births occurring at home or in birth centres.40 A meta - analysis in the same year demonstrated higher perinatal mortality associated with homebirth41 but has been strongly criticised on methodological grounds.5, 42 The Birthplace in England study, 43 the largest prospective cohort study on place of birth for women at low risk of complications, analysed a composite outcome, which included stillbirth and early neonatal death among other serious morbidity.

The strength of this study is its prospective population - based cohort design with a large number of subjects and the possibility to adjust for all major confounders.

When logistic models were stratified by the presence or absence of hypertensive disease, only maternal age older than 34 years (odds ratio [OR], 1.4; 95 % confidence interval [CI], 1.0 - 2.0), pregnancy - associated plasma protein - A of the 95th percentile or less (OR, 1.9; 95 % CI, 1.2 - 3.1), and alpha fetoprotein of the 95th percentile or greater (OR, 2.3; 95 % CI, 1.4 - 3.8) remained statistically significantly associated for abruption.In this large, population - based cohort study, abnormal maternal aneuploidy serum analyte levels were associated with placental abruption, regardless of the presence of hypertensive disease.

«For this large cohort of women who planned midwife - led home births in the United States, outcomes are congruent with the best available data from population - based, observational studies that evaluated outcomes by intended place of birth and perinatal risk factors.

Commenting on the study, ESMO spokesperson Dirk Arnold, MD, PhD, from Instituto CUF de Oncologia in Lisbon, Portugal, said «this large population - based cohort - control study impressively confirms the hypothesis of an association of colorectal polyps with diets and other life - style factors.

While further study of larger patient groups with longer follow - up times is needed for this cohort of prostate cancer patients, this study is pivotal in providing evidence for change in practice.»

Additional studies in larger cohorts will be needed to validate these findings, and more biomarkers will be needed to get the completely accurate set needed to screen the general population with the long term goal of identifying precursor lesions before they become malignant.

Findings from this UK cohort are confirmed by evidence for adult - onset ADHD world - wide: a study from Brazil will be published by JAMA Psychiatry alongside this research, which also identified a large proportion of adults with ADHD as not having the disorder in childhood.

Adams points out that Cohort A is the first phase II study of an immunotherapy for triple negative breast cancer to be reported and represents the largest cohort of patients with mTNBC treated with immunotherapy toCohort A is the first phase II study of an immunotherapy for triple negative breast cancer to be reported and represents the largest cohort of patients with mTNBC treated with immunotherapy tocohort of patients with mTNBC treated with immunotherapy to date.

Young adults with thinner cortex in particular brain regions are more impulsive during a decision - making task than teens with thicker cortex, according to a large correlational study of adolescents from the Philadelphia Neurodevelopmental Cohort.

In this 9 - centre, large ongoing cohort study, researchers evaluated the survival in Caucasian CHB patients with or without cirrhosis who have been receiving ETV or TDF.

Dr Matt Hurles, who led the study from the Sanger Institute, said: «This study has the largest cohort of such families in the world, and harnesses the power of the NHS, with 200 clinical geneticists and 4,000 patients.

However, study strengths include a very large sample size and long follow - up, with consistent results across three cohorts.

Researchers were able to access CSF samples from the deprenyl and tocopherol antioxidative therapy of Parkinsonism (DATATOP) study, which is the largest cohort assembled to date with longitudinal collection of biological fluids and clinical data from PD patients.

The aim of this new study was to determine whether 2D: 4D was associated with the risk of severe knee or hip OA requiring total joint replacement in a large cohort study.

«The study represents the largest cohort of patients with OACICH to date and reports 2 clinically valuable associations.

According to Eva S. Schernhammer, MD, DrPH, currently Associate Professor of Medicine, Harvard Medical School, and Associate Epidemiologist, Department of Medicine, Brigham and Women's Hospital, Boston, this study «is one of the largest prospective cohort studies worldwide with a high proportion of rotating night shift workers and long follow - up time.

Conducting a cross-sectional study of a large cohort of patients with different levels of cognitive impairment and different disease stages, the researchers found that the amounts of a TREM2 fragment in the cerebrospinal fluid were highest during early stages characterized by mild cognitive impairment symptoms.

The Columbia researchers with colleagues in Finland conducted an analysis of data from the Finnish Prenatal Study of Schizophrenia, a large, national birth cohort with an extensive bio-bank.

Of the dozen of these metabolites that were measured in cohorts from the longitudinal Framingham Heart Study (the long - term 1948 study to identify the common contributive factors of cardiovascular disease by following its development in a large subject group) levels of glycerol turned out to be «significantly correlated» with resting heart rate, another indicator of fitness, as measured in the sStudy (the long - term 1948 study to identify the common contributive factors of cardiovascular disease by following its development in a large subject group) levels of glycerol turned out to be «significantly correlated» with resting heart rate, another indicator of fitness, as measured in the sstudy to identify the common contributive factors of cardiovascular disease by following its development in a large subject group) levels of glycerol turned out to be «significantly correlated» with resting heart rate, another indicator of fitness, as measured in the studystudy.

Limitations of the study included the small number of participants; the authors advise that the study should be replicated ideally with a larger cohort.

«Metabolomics is now often used to accompany large genomic cohort studies from biobanks, to correlate genotype and genomic variants with specific phenotypes, to complement nutritional studies monitoring food components or endogenous metabolites, or to support measurements in epidemiology studies,» says Andreas Huhmer, director of proteomics and metabolomics marketing at Thermo Fisher Scientific, headquartered in Waltham, Massachusetts.

The NYGC and its founding member institutions are conducting additional studies involving Watson to help accelerate the discovery of potentially actionable sequence variants in various types of cancer, including an ongoing study that involves DNA and RNA from a larger cohort of glioblastoma patients, and a study of 200 patients with different types of cancer.

The LALES study, conducted among 4,876 Latinos in Los Angeles with a mean age cohort of 54.8 years old, indicates that Latinos diagnosed with bilateral AMD with large drusen (the lipids or fatty proteins that are yellow deposits under the retina) and depigmentation as well as a more severe AMD had a substantially lower health - related quality of life as compared to those with AMD lesions in only one eye.

Conclusions and Relevance The study results, derived from a large cohort of patients with long follow - up time, suggest that the rate of revision septorhinoplasty is low, but certain patient characteristics are associated with higher revision rates.

The study results, derived from a large cohort of patients with long follow - up time, suggest that the rate of revision septorhinoplasty is low, but certain patient characteristics are associated with higher revision rates.

«This study has the largest cohort of such families in the world, and harnesses the power of the NHS, with 200 clinical geneticists and 4,000 patients.

As recently shown in a collaborative analysis of 10 large cohort studies, women appear to feature more often the metabolically healthy obese phenotype with normoglycemia and without dyslipidemia and hypertension (7 % — 28 %) compared with males (2 % — 19 %)(39).

Very recently, a rather limited number of retrospective studies, utilizing whole genome sequencing (Talkowski et al., 2012) or whole exome sequencing (WES) in small cohorts of neonates and aborted fetuses with various ultrasound and / or post-mortem structural abnormalities (Carss et al., 2014; Drury et al., 2015; Alamillo et al., 2015; Westerfield et al., 2015), provided initial proof - of - principle of large - scale prenatal next generation sequencing (NGS).

With TESS, it will be possible to study the masses, sizes, densities, orbits and atmospheres of a large cohort of small planets, including a sample of rocky worlds in the habitable zones of their host stars.

Data shared through RD ‐ Connect is accessible beyond the usual institutional and national boundaries and researchers across the world can benefit from the opportunity to work with others with an interest in the same field, pool data to create larger cohorts, find confirmatory cases, and access samples for further study.

You may have large - scale RNA - Seq data, and don't know whether technical effects are relevant; or you may have large grouped cohorts of DNA - Seq data, and need to narrow down your variant list to a few significant ones, associated with disease; or you may want to do an integrated study on a dataset containing RNA and ChIP - Seq samples.

In the first study (Klaassen et al., 2008) mutational analysis in a large cohort of 63 unrelated adult probands with LVNC and absence of other congenital heart anomalies was performed.

We included prospective cohorts with at least 50 cardiovascular disease events (mortality, morbidity, or both) to minimise the potential for reporting bias, in which large but unreliable effects might be seen in small studies.

The LEAP study, designed and conducted by the ITN with additional support from FARE and led by Professor Gideon Lack at Kings College London, is the first randomized trial to prevent food allergy in a large cohort of high - risk infants.

Conversely, within non-diabetic populations, periods of IER (75 - 85 % ER on restricted days) do not typically affect fasting glucose levels 37, 41, 45, 48 or HbA1c 41, 48; results of which can often be replicated by short term CER studies.62 - 65These findings are unsurprising given that frank hyperglycaemia within the T2DM diagnostic range is effectively a late - stage manifestation of IR, which along with compensatory increases insulin secretion, can precede the onset of T2DM by many years.66, 67 Findings from one large scale prospective cohort study, Whitehall II, reveal a sharp increase in the trajectory towards fasting hyperglycaemia which is only detectable three years prior to diagnosis with T2DM.67 Consequently, it can be argued that changes in circulating insulin concentrations, fasting (hepatic) insulin sensitivity and glucose uptake / clearance are more sensitive markers of deteriorating glucose control than fasting glycaemia in non - diabetics.68 - 70

, Maternal caffeine intake during pregnancy is associated with birth weight but not with gestational length: results from a large prospective observational cohort study, 2013

Looking at 3 large prospective cohorts (Nurses Health Study 1 and 2, and the Health Professional Follow Up), the researchers from Harvard looked at the risk of type 2 diabetes with the consumption of whole fruits and fruit juice.

In the large cohort study mentioned above, the most common allergy was peanut with a prevalence of 2.6 %, followed by milk at 2.2 %, egg at 1.8 %, shellfish at 1.5 % and soy at 0.7 %.

«His meta - analysis of the cutting - edge research on large - cohort studies of what sugar does to populations across the world, alongside his own clinical observations, has him credited with starting the war on sugar,» writes Zoe William in The Guardian.

20Sengpiel V. et al. (2013) Maternal caffeine intake during pregnancy is associated with birth weight but not with gestational length: results from a large prospective observational cohort study.

The pill also increases your risk for inflammatory bowel diseases like Crohn's disease; in fact, two large prospective cohort studies of American women linked oral contraceptive use with Crohn's.

Average long - term weight gain in nonobese populations is gradual — in the cohorts we studied, about 0.8 lb per year — but accumulated over time, even modest increases in weight have implications for long - term adiposity - related metabolic dysfunction, diabetes, cardiovascular disease, and cancer.21 - 24 Whereas weight changes associated with any single lifestyle factor were relatively modest in our three cohorts, in the aggregate, changes in diet and physical activity accounted for large differences in weight gain.

In this study, the researchers investigate whether consumption of fruits and vegetable with a higher fiber content or lower glycemic load is more strongly associated with a healthy weight than consumption of fruits and vegetables with a lower fiber content or higher glycemic load by analyzing data on weight and diet changes among US men and women enrolled in three large prospective cohort studies set up to examine risk factors for major chronic diseases.

The case - cohort design combines the advantages of a prospective cohort with the efficiency and power of a large case - control study.

Since the WCRF report, Luo et al [59] studied the association between the drinking coffee and the risk of pancreatic cancer in a large population - based cohort study in Japan and concluded there was no increased risk of pancreatic cancer with coffee intake.

Consistently, all students and all studied cohorts at schools with larger book collections are more likely to earn Advanced and less likely to earn Below Basic scores than their counterparts at schools with smaller book collections.

The Fragile Families and Child Wellbeing Study The Fragile Families and Child Wellbeing Study is a new data set that follows a cohort of approximately 5,000 children born between 1998 and 2000 in medium to large U.S. cities.37 Approximately 3,700 of the children were born to unmarried mothers and 1,200 to married mothers.38 The study initiated interviews with parents at a time when both were in the hospital for the birth of their child and therefore available for interviews.39 As a consequence, FFCWS is able to comprehensively detail the characteristics of both parents and the nature of their relationship at the time of the child's bStudy The Fragile Families and Child Wellbeing Study is a new data set that follows a cohort of approximately 5,000 children born between 1998 and 2000 in medium to large U.S. cities.37 Approximately 3,700 of the children were born to unmarried mothers and 1,200 to married mothers.38 The study initiated interviews with parents at a time when both were in the hospital for the birth of their child and therefore available for interviews.39 As a consequence, FFCWS is able to comprehensively detail the characteristics of both parents and the nature of their relationship at the time of the child's bStudy is a new data set that follows a cohort of approximately 5,000 children born between 1998 and 2000 in medium to large U.S. cities.37 Approximately 3,700 of the children were born to unmarried mothers and 1,200 to married mothers.38 The study initiated interviews with parents at a time when both were in the hospital for the birth of their child and therefore available for interviews.39 As a consequence, FFCWS is able to comprehensively detail the characteristics of both parents and the nature of their relationship at the time of the child's bstudy initiated interviews with parents at a time when both were in the hospital for the birth of their child and therefore available for interviews.39 As a consequence, FFCWS is able to comprehensively detail the characteristics of both parents and the nature of their relationship at the time of the child's birth.

The Fragile Families and Child Wellbeing Study, which followed a cohort of nearly 5,000 children born in large U.S. cities between 1998 and 2000 (roughly three - quarters of whom were born to unmarried parents), sheds light on the relationships of low - income, unmarried parents.11 The vast majority of unmarried fathers in the study indicated they were romantically involved with their child's mother at the time of the child's bStudy, which followed a cohort of nearly 5,000 children born in large U.S. cities between 1998 and 2000 (roughly three - quarters of whom were born to unmarried parents), sheds light on the relationships of low - income, unmarried parents.11 The vast majority of unmarried fathers in the study indicated they were romantically involved with their child's mother at the time of the child's bstudy indicated they were romantically involved with their child's mother at the time of the child's birth.