By analyzing genome sequence data from human populations, including 1269 individuals from sub-Saharan Africa, we identify a diverse array of
large copy number variants affecting the host invasion receptor genes GYPA and GYPB We find that a nearby association with severe malaria is explained by a complex structural rearrangement involving the loss of GYPB and gain of two GYPB - A hybrid genes, which encode a serologically distinct blood group antigen known as Dantu.
Not exact matches
If staff need to send out emails to a
large number of people on a mailing list, then they should use a blind carbon
copy (bcc), so that recipients» names can't be seen by other people.
Nevertheless, the move was a prescient one: 25 went on to sell a staggering 3.4 million
copies in its first week — the
largest number since Nielsen began tracking the figure in 1991.
With
numbers that
large, it's reasonable to expect few, if any, carbon
copies among China - specific ETFs.
During Lent, radical Muslims handed out
large numbers of Qur «ans on street corners and announced plans to distribute 25 million German - language
copies of their holy book in order to win Germans to their faith.
Again, the increased activity in these areas was associated with the
number of
copies of the A allele carried by individuals — people with two
copies showed a
larger increase in activity than those with just one.
Venken first sought a vector that could handle
large amounts of DNA efficiently, settling on a bacterial artificial chromosome, which was designed a couple years ago and is known to maintain only a few
copies of the DNA (though it can produce a high
number of
copies if it is induced).
It is the
largest ever to analyze genetic structural variants or
copy -
number variants (CNVs) of Tourette.
The third type are
large - scale
copy number variations, which the team described in earlier work.
They also have an average of about 13
large DNA duplications or deletions, called
copy number variations (CNVs).
The result is that researchers are left with a
large amount of fragments that they must try to put together in the digitized
copy — much like a jigsaw puzzle with an extreme
number of pieces.
The mice seem to develop normally when only one
copy of the gene is removed, but microscopic inspection reveals a
number of small «gaps,» or disorganized regions of tissue (on the scale of a few nanometers) on their aortas, the
largest artery in their bodies.
Although Robinson says his field «has a
large number of people who don't like computers,» and who are suspicious of the analysis, he says others are picking up the technique, including a group in Germany hoping to analyze 5000
copies of the Greek New Testament, and another group working on Dante's Divine Comedy.
With its
large sample size, this study had the power to find
copy number variants with
large effects that occur in more than 0.1 percent of schizophrenia cases.
Although none of the German Neolithic samples carries the
copy number expansion of the AMY2B gene associated with starch digestion, we find that this gene is present in three
copies in NGD, though this is due to a
large segmental duplication that is shared with multiple modern dogs, an event separate from the tandem AMY2B duplications.
The
largest numbers of variants identified by genome - wide association are
copy -
number changes, which have a greater phenotypic effect than do single nucleotide polymorphisms.
CCG uses high - throughput techniques to identify and study mutations,
large rearrangements of the genome, increases and decreases in DNA
copy number, chemical modifications to DNA, and changes in the expression of RNA and proteins.
This study of human genetic variation and its relationship to health and disease involves a
large number of study participants and will capture not only common single nucleotide variations but also rare
copy number and structural variants that are increasingly thought to play an important role in complex disease.
We aim to push its limits on all fronts to establish a technique which combines nanometre 3D resolution with maximum labelling efficiencies, absolute measurements of protein
copy numbers, precise multi-colour measurements, high - throughput for
large scale statistics and novel data analysis approaches, to address the vast array of exciting biological questions at the nanoscale, which are becoming accessible only now.
A third contributing type is
large - scale
copy number variations, which the team described in earlier work.
Our results establish gene conversion as a previously under - appreciated mechanism of generating
copy number changes in humans and reveal the exceptionally
large size of the conversion events that can occur.
Molecular profiling of
large tumour
numbers has also allowed the annotation of more than 13 million non-coding mutations, 18 029 gene fusions, 187 429 genome rearrangements, 1 271 436 abnormal
copy number segments, 9 175 462 abnormal expression variants and 7 879 142 differentially methylated CpG dinucleotides.
Variations in the genetic code, from single point mutations to
large structural or
copy number alterations, influence susceptibility, onset, and progression of genetic diseases and tumor transformation.
Times reporter Howard Blume won't say, but given the
large number of union sympathizers and others who received advance
copies, one might well ask: Who didn't leak it?
I will be delivering this to
large numbers of students, lecture style, and will be giving students a
copy of the slides for them to annotate as I talk.
Because we are on a mission to train
large numbers of beginning teachers nationally we have settled on an all - inclusive fee that covers training, a
copy of Conversations, PDF of materials, travel and lodging.
If a self - published book sells 5,000
copies in its first six months, an agent or publisher is not going to let first rights issues stand in their way (always assuming that the book is well - written [I've known self - pubbed authors who've managed to sell
large numbers of really pretty bad books] and the sales suggest a market that could be tapped, rather than one that has been exhausted, as with some niche products).
When libraries purchase videos a
large number of titles are available under a one
copy / one user access plan.
Most MG authors will tell you they sell as much (or more) in print as they do in ebook, but it's hard to move
large numbers of print
copies if you're not in bookstores (and with POD prices high relative to mass market print runs).
Romance also has much
larger numbers than sf / f — I recall a romance writer friend of mine complaining that her latest mmpb release «only» sold 80,000
copies, and wasn't going back for a second printing.
A
large number of excerpts have been shared by news outlets who received advanced
copies of the book, driving the pre-orders on Amazon.
That house would do what many publishing houses do: pay authors
large advances for books that would (hopefully) sell a substantial
numbers of
copies.
While it's important to seek out some reputable endorsers and reviewers who have a
large group of readers, I don't think self - published authors realize the
number of readers they need to pull off a self - published book that sells more than 25 - 50
copies.
If going with a
larger print run on offset lithographic presses makes sense because you'll need a
large number of
copies as cost - effectively as possible, then we'll get your books into production in our offset plant.
For
large numbers of
copies, the per - unit costs for POD are higher than for press printing.
If you have to print a
large number of
copies, the per
copy cost with offset printing becomes much less.
Publishers send out a
large number of advance review
copies.
That's not to say that people won't shell out more for your books or that it's not worth pricing them higher in some instances, but you'll find that selling a
larger number of
copies becomes a lot easier within this affordable sweet spot.
Literary fiction traditionally sells in smaller quantities: but even so, will usually have a print run of over 1,000
copies even here, in the UK: in the USA, the
numbers are proportionately
larger.
Among the titles arriving next week, the leader in both holds and
number of
copies ordered is Brotherhood in Death by J.D. Robb (PRH / Berkley; Brilliance Audio) followed by Breakdown: An Alex Delaware Novel, by Jonathan Kellerman (PRH / Ballantine; PRH / BOT Audio; PRH
Large Print).
I am hoping that allowing readers to browse the physical
copies of the books and then also offering the alternative of buying the e-book right there will result in
large numbers of e-book sales.
Author
copies and shipping can get expensive (and become a hassle at the post office) if you offer a
large number of prizes.
Because there is a
large number of breeds, breed names are almost impossible to read on the whole graphs, but you can download a
copy of the file or I have split the graph in two to improve legibility.
Should you require a hard
copy or
large numbers of any of the publications listed then please click here to see our contact details.
You agree not to engage in any of the following prohibited activities: (i)
copying, distributing, or disclosing any part of the Service in any medium, including without limitation by any automated or non-automated «scraping»; (ii) using any automated system, including without limitation «robots,» «spiders,» «offline readers,» etc., to access the Service in a manner that sends more request messages to the Company servers than a human can reasonably produce in the same period of time by using a conventional on - line web browser (except that Humble Bundle grants the operators of public search engines revocable permission to use spiders to
copy materials from Humble Bundle for the sole purpose of and solely to the extent necessary for creating publicly available searchable indices of the materials, but not caches or archives of such materials); (iii) transmitting spam, chain letters, or other unsolicited email; (iv) attempting to interfere with, compromise the system integrity or security or decipher any transmissions to or from the servers running the Service; (v) taking any action that imposes, or may impose in our sole judgment an unreasonable or disproportionately
large load on our infrastructure; (vi) uploading invalid data, viruses, worms, or other software agents through the Service; (vii) collecting or harvesting any personally identifiable information, including account names, from the Service; (viii) using the Service for any commercial solicitation purposes; (ix) impersonating another person or otherwise misrepresenting your affiliation with a person or entity, conducting fraud, hiding or attempting to hide your identity; (x) interfering with the proper working of the Service; (xi) accessing any content on the Service through any technology or means other than those provided or authorized by the Service; (xii) bypassing the measures we may use to prevent or restrict access to the Service, including without limitation features that prevent or restrict use or
copying of any content or enforce limitations on use of the Service or the content therein; (xiii) sell, assign, rent, lease, act as a service bureau, or grant rights in the Products, including, without limitation, through sublicense, to any other entity without the prior written consent of such Products» (defined below) licensors; (xiv) circumventing Service limitations on the
number of Products you may purchase, including, without limitation, creating multiple accounts and purchasing a total
number of Products through such multiple accounts which exceed the per - user limitations; or (xv) except as otherwise specifically set forth in a licensor's end user license agreement, as otherwise agreed upon by a licensor in writing or as otherwise allowed under applicable law, distributing, transmitting,
copying (other than re-installing software or files previously purchased by you through the Service on computers, mobile or tablet devices owned by you, or creating backup
copies of such software or files for your own personal use) or otherwise exploiting the Products (defined below) in any manner other than for your own private, non-commercial, personal use.
The Call of Duty franchise has to date sold over 90 million
copies and with such a
large number...
Nielsen also reported that a
large number of today's youth still have the ability to own a
copy of a matured - rated game.
Wilke has also participated in a
large number of significant group exhibitions including the forthcoming exhibition Virginia Woolf: an exhibition based on her writing, Tate St Ives (2018); Delirious: Art at the Limits of Reason, 1950 - 1980, Met Breuer, New York (2017); Body Talk, Rose Art Museum, Waltham (2017); Feminist Avant - Garde of the 1970s, ZKM, Karlsruhe (2017), travelling to Stavanger Art Museum, Norway and The Brno House of Arts, Brno (2018); I Remember Not Remembering, Scottsdale Museum of Contemporary Art (2017); The Beguiling Siren is Thy Crest, Museum of Modern Art in Warsaw (2017); Performing for the Camera, Tate Modern, London (2016); Revolution in the Making: Abstract Sculpture by Women, 1947 - 2016, Hauser & Wirth & Schimmel, Los Angeles (2016); Americana: Formalizing Craft, Perez Art Museum, Miami (2013); Aquatopia: The Imaginary of the Ocean Deep, Nottingham Contemporary (2013); Human Nature, Los Angeles County Museum of Art (2012); Naked Before the Camera, Metropolitan Museum of Art, New York (2012); Elles: Women Artists from the Centre Pompidou, Seattle Art Museum (2012); The Body as Protest, Albertina Museum, Vienna (2012); Ourselves, Australian Centre for Contemporary Art, Melbourne (2012); The Original
Copy: Photography of Sculpture, 1839 to Today, MoMA, New York and elles@centrepompidou, Centre Pompidou, Paris (2010).
For firms with
large numbers of clients, portals also can be a significant timesaver by eliminating the process of hunting down
copies of old returns every time a client calls looking for one.
He accepted that, as the invention is a pharmaceutical substance, it was unlikely that any other company would have attempted to
copy it until it had achieved regulatory approval but that once it was approved a
large number of generic pharmaceutical competitors would most likely have
copied Myoview in absence of the patents.