Sentences with phrase «large decreases over»

Results demonstrate important changes in students» drinking during the calendar year, including expected large increases during the month of a one - day festival, large decreases over the summer, and resumption of relatively high quantities upon return to school.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Second, the debate over immigrant impacts on American wages is confined to the lower single digits — immigrants may increase the relative wages for some Americans by a tiny amount and decrease them by a larger amount for the few Americans who directly compete against them.

Finally, we have reviewed a large - scale study on high blood pressure showing an association between high levels of protein intake (in the vicinity of 100 grams per day) and significantly decreased risk of high blood pressure over an 11 - year period of time.

A very large increase also took place over the period 1992 to 1997 in the case of organic dairy cows (469 percent), layer hens (1123 percent) and broilers (120 percent) with certified organic livestock being raised in 23 States; but over the same period, the production of organic beef cows decreased by 35 percent, hogs and pigs by 65 percent and sheep and lambs by 42 percent.

While some symptoms of blues will decrease over time once hormone levels are regulated, other women find themselves engulfed in a larger scale depression and may require medication to help them during this time.

Not only would design - build save taxpayers over $ 113 million and decrease construction time by a crucial two years, but without it, massive trucks would be compelled to travel through Downtown Brooklyn — the City's third largest commercial district — because the BQE would be unable to support their weight.

Thanks to the distribution of 400 million mosquito nets coated with insecticide, and hundreds of millions of testing kits and treatment courses, made possible by the committed efforts of the world's largest investors in the malaria effort, notably, the United States, the United Kingdom, The Global Fund to Fight AIDS, TB and Malaria, and the World Bank, malaria deaths in sub-Saharan Africa have decreased by one third over the past ten years.

But the bottom line is that aside from what anyone can say about what this administration has been doing here in Central New York — it's working: No region of the state has seen as large a decrease in the unemployment rate than Central New York over the past three years: 8.6 percent in December 2010, 6.5 percent today.

Key to the basin's identification as a potential impact crater are the decrease in the strength of Earth's gravity over the site, indicating a large basin filled with younger low - density sediments, and a strong increase in the strength of Earth's magnetism at the site.

Now new research shows that these eruptions on the sun's surface not only send bursts of energetic particles into Earth's atmosphere causing disturbances in the magnetic field, but they may also significantly decrease the number of free electrons over large areas in the polar region of the ionosphere — the ionized part of the upper atmosphere.

«Cold, hot or dry: Persistent weather extremes associated with decreased storm activity: Decrease in storm activity over large parts of the US, Europe, Russia, and China is found to influence weather extremes.»

A decrease in solar radiation, they suspect, forces the jet stream to fold back on itself over the Atlantic, creating a large spiral of air that can stay stable for weeks and prevent westerly winds from reaching Europe.

Over this 100 - year period, O'Gorman found that average snowfall decreased substantially in many Northern Hemisphere regions in warm - climate scenarios compared with the milder control climates, but that snowfall amounts in the largest snowstorms did not decrease to the same extent.

The research finds that, over the past few decades, large areas of forest and savannah have been converted to cropland, meaning that the overall area that could be burned by wildfires has decreased.

For example, a 2011 study of 50 people with chronic neck pain found that those who received five treatments with cupping therapy over two weeks reported a larger decrease in their pain than people who didn't receive the treatment.

In a very large scale study in Denmark involving over 50,000 adults between the ages of 50 — 64 years, intake of oats has been associated with decreased risk of heart attack (also known as myocardial infarct, or MI).

Over that two - year period, the average difference between NAEP and state proficiency levels decreased from 35 percent to 30 percent, the largest tightening of state standards in any two - year period since NCLB was first established (see Figure 2).

Sarah continues, «The comparative element of the tool makes it easy to digest the large numbers involved in the decrease in travel time over the years.

The state's largest teachers union, the Wisconsin Education Association Council (WEAC), saw a dramatic decrease in membership over a short period of time: falling from about 98,000 members in 2011 to about 40,000 in 2015.

Larger tires, with or without larger wheels, increase ground clearance, ride over short obstacles and holes more smoothly, provide more cushioning and decrease ground loading which is important on soft surLarger tires, with or without larger wheels, increase ground clearance, ride over short obstacles and holes more smoothly, provide more cushioning and decrease ground loading which is important on soft surlarger wheels, increase ground clearance, ride over short obstacles and holes more smoothly, provide more cushioning and decrease ground loading which is important on soft surfaces.

First: Amazon began as a bookstore, and while over the years it has become a large and diverse retailer of everything under the sun, it hasn't decreased its commitment to bookselling.

In the worst market decline over that time period large stocks went down nearly 50 % but dividend stocks only decreased 29 %.

Over a long time if that trend continues, spread over a large number of people, on average, it will be a real pay decreOver a long time if that trend continues, spread over a large number of people, on average, it will be a real pay decreover a large number of people, on average, it will be a real pay decrease.

Also the desire to roll over money into a 401k plan at one's new job has decreased too — far too many employer - sponsored retirement plans have large management fees and the investments are rarely the best available: one can generally do better keeping ex-401k money outside a new 401k, though of course new contributions from salary earned at the new employer perforce must be put into the employer's 401k.

With uncertainty over Fed moves, there's also liquidity risk — if banks decide to stop making the large short term loans, the value of the underlying REIT will decrease.

Meanwhile, the individual District with the largest decrease was in the 11th Circuit: Southern Florida recorded just over 18,000 bankruptcy filings in 2016, which was 22.3 percent fewer filings than 2015.

Those seeing the largest decrease in the amount of bankruptcy filings over 2015 numbers were those filing in the 9th Circuit — covering California, Arkansas, Arizona, Hawaii, Idaho, Montana, Nevada, Oregon, Washington, Guam and the Northern Mariana Islands — with 9.9 percent fewer cases.

For example, the County of Los Angeles Department of Animal Care and Control (DACC), regarded as the largest municipal animal control agency in the U.S., has seen a 10 % decrease in the euthanasia rate of cats over a five - year period.

That's not how it's explained on the BirdLife International website, where the «large and statistically significant decrease over the last 40 years in North America» is attributed to «widespread habitat fragmentation» and extensive hunting («over 20,000,000 individuals were recently being killed annually by hunters in the USA»).

Generally, this decrease is noticed in dams of large breeds over the age of 5.

Despite a 6.6 % increase over last year in pets surrendered by their owners and a nearly 4 % increase in the number of pets that arrived this year, we were still able to decrease euthanasia to a record low number while saving 9,459 pets — the largest number of dogs, cats and other pets saved in Kansas City's history.

We find that without dramatic increases in the area of forests, without substantially positive changes in land - use practices, without large net positive effects of CO2 or climate change in the future, or without some other new significant carbon storage mechanism, the U.S. carbon sink itself will decrease substantially over the 21st century.

It is interesting to note that population density of in the center of large cities and small towns has decreased significantly in many places over the 20th century.

Since this isn't the case (see my previous post), the effect must be nonlinear, decreasing for larger changes in GCR, or transient, fading away over time.

Broadly stated: if you reject a lease and take a large portion of a commodity (here coal, but it could have been natural gas, tar sands, etc.) off the market, you decrease the supply, increase the cost, and, over the long term, decrease the use of that commodity.

Non-hydro renewables have not managed to do so to date in any large electricity grid, (hydro can not help; its capacity growth is limited so it will decrease its share of global electricity generation over future decades).

In summer and autumn the CSIRO projections were for smaller decreases in rainfall than in winter and spring, but the observed change was a substantial decrease: in fact, as large a decrease between the successive 11 - year periods as CSIRO projected on the high global warming scenario over the 40 - year period from 1990 to 2030.

â $ œSea ice extent averaged over the Northern Hemisphere has decreased correspondingly over the past 50 years â $ ¦ The largest change has been observed in the summer months with decreases exceeding 30 %.

«Sea ice extent averaged over the Northern Hemisphere has decreased correspondingly over the past 50 years... The largest change has been observed in the summer months with decreases exceeding 30 %.

Abstract — 2008 Climate and wildfires in the North American boreal forest... Climate controls the area burned through changing the dynamics of large - scale teleconnection patterns (Pacific Decadal Oscillation / El Niño Southern Oscillation and Arctic Oscillation, PDO / ENSO and AO) that control the frequency of blocking highs over the continent at different time scales......... Since the end of the Little Ice Age, the climate has been unusually moist and variable: large fire years have occurred in unusual years, fire frequency has decreased and fire — climate relationships have occurred at interannual to decadal time scales...... http://rstb.royalsocietypublishing.org/content/363/1501/2315.short ----------------------

For the entire Northern Hemisphere, there is evidence of an increase in both storm frequency and intensity during the cold season since 1950,1 with storm tracks having shifted slightly towards the poles.2, 3 Extremely heavy snowstorms increased in number during the last century in northern and eastern parts of the United States, but have been less frequent since 2000.11,15 Total seasonal snowfall has generally decreased in southern and some western areas, 16 increased in the northern Great Plains and Great Lakes region, 16,17 and not changed in other areas, such as the Sierra Nevada, although snow is melting earlier in the year and more precipitation is falling as rain versus snow.18 Very snowy winters have generally been decreasing in frequency in most regions over the last 10 to 20 years, although the Northeast has been seeing a normal number of such winters.19 Heavier - than - normal snowfalls recently observed in the Midwest and Northeast U.S. in some years, with little snow in other years, are consistent with indications of increased blocking (a large scale pressure pattern with little or no movement) of the wintertime circulation of the Northern Hemisphere.5 However, conclusions about trends in blocking have been found to depend on the method of analysis, 6 so the assessment and attribution of trends in blocking remains an active research area.

«Our analysis shows warming underway by 1800, large variations up and down throughout the 19th century, and that variability on the 3 - 15 year scale has been dramatically decreasing over the past two centuries.»

We find that changes in naturally occurring climate variability patterns can play a major role in large regional changes (especially cooling over North America and Europe as solar output decreases).

These range from decreases of 10 - 15 % over much of the industrialized Northern Hemisphere for the mid-range scenario to CO increases worldwide under the high - emission projection, with the largest changes over central Africa (20 - 30 %), southern Brazil (25 - 40 %) and South and East Asia (20 - 50 %).

Over the rest of the world, because of large - scale deforestation and erosion, the topsoil reservoir is probably decreasing.

According to the model, temperatures in the North Atlantic and Greenland showed the largest decrease, with slightly less cooling over parts of North America and Europe.

Thus the influence of aerosols and ozone over the period with the largest decrease in aerosols.

This cap is calculated once and is held constant throughout all compliance periods, which means as the mass goals decrease over the compliance period, the output - based set - asides will make up an increasingly larger share of available allowances.

Assuming a good bit of this was added after the natural warming cycle was started we are probably looking at closer to 1200 ppm over the next century or two before C02 levels begin to decrease again as this natural green house locks up carbon primarily in phytoplankton blooms caused by fertilization from the new large desert regions near the equator and excessive erosion from very intense storm systems the develop in such a hot house climate.