Clearly, in some cases, this factor could make
a large difference to the outcome.
Not exact matches
Its
large sample size provided the power
to detect
differences in rare adverse
outcomes.
The strengths of the study include the ability
to compare
outcomes by the woman's planned place of birth at the start of care in labour, the high participation of midwifery units and trusts in England, the
large sample size and statistical power
to detect clinically important
differences in adverse perinatal
outcomes, the minimisation of selection bias through achievement of a high response rate and absence of self selection bias due
to non-consent, the ability
to compare groups that were similar in terms of identified clinical risk (according
to current clinical guidelines) and
to further increase the comparability of the groups by conducting an additional analysis restricted
to women with no complicating conditions identified at the start of care in labour, and the ability
to control for several important potential confounders.
«We found small but meaningful
differences in developmental
outcomes between late preterm infants and full term groups, which if applied
to larger populations, may have potentially significant long term public health implications,» says lead author Prachi Shah, M.D., a developmental and behavioral pediatrician at U-M's C.S. Mott Children's Hospital.
The primary
outcome with the
largest difference in this sensitivity analysis was preterm birth, where an analysis restricted
to trials with lower risk of bias suggested a
larger treatment effect: RR 0.64, (95 % CI 0.51
to 0.81) compared with RR 0.77, (95 % CI 0.62
to 0.94) in the overall analysis.
The study's primary limitation is that the sample was not
large enough
to detect
differences in the components of the primary endpoint, only a composite of these
outcomes.
Of the factors examined that combine
to create the County Health Rankings, the counties ranked lowest for poverty, measured as the number of children below the poverty line, had twice the relative risk of asthma as an
outcome from PM2.5 exposure than those counties ranked highest (the
largest difference).
Additionally, within each of the 7 specific categories of clinical research (October 2002 council only), there were no significant
differences in review
outcomes for applications reviewed by study sections reviewing 1 %
to 25 % clinical applications compared with
outcomes in study sections reviewing
larger percentages of clinical applications.
Similar
to the animal studies,
large variations among the exposure protocols, measured
outcomes, and subject susceptibilities likely explain much of the
differences among findings and must be considered when interpreting the results.
In a
large meta - analysis published today in Annals of Internal Medicine, researchers failed
to find the dramatic
differences in health
outcomes you may expect between the two fat groups.
Simply put, just because a 22.7 percent spending increase is
large enough
to eliminate the average
outcome differences between the poor and non-poor it does not mean that a 22.7 percent spending increase is
large enough
to eliminate the
difference in
outcome between the very poor and the very wealthy or
differences across other measures of socioeconomic status.
The marginal cost of choosing one textbook over another is generally close
to zero (because all textbooks cost about the same amount [xiv]-RRB-, and several recent studies have documented meaningfully
large differences in student
outcomes.
Yet, when I and a group of researchers from Harvard, MIT, Duke and the University of Michigan subsequently tracked down the admission lottery winners, and compared their
outcomes to the lottery losers, we found
large differences in achievement.
The
difference between student
outcomes for online and face -
to - face classes... was
larger in those studies contrasting conditions that blended elements of online and face -
to - face instruction with conditions taught entirely face -
to - face.
In fact, levels are not as important as skills here; having a collection of high level demons is totally useless if they don't have the correct abilities
to defeat specific enemies, because skills like paralysis can make a
large difference in the
outcome of a battle.
In some cases, the stat
differences alone can determine the
outcome of a match due
to its interesting metagame effects while in other matches it might become irrelevant if player skill
difference is
large enough.
The program of prenatal and infancy home visiting by nurses, tested with a primarily white sample, produced a 48 percent treatment - control
difference in the overall rates of substantiated rates of child abuse and neglect (irrespective of risk) and an 80 percent
difference for families in which the mothers were low - income and unmarried at registration.21 Corresponding rates of child maltreatment were too low
to serve as a viable
outcome in a subsequent trial of the program in a
large sample of urban African - Americans, 20 but program effects on children's health - care encounters for serious injuries and ingestions at child age 2 and reductions in childhood mortality from preventable causes at child age 9 were consistent with the prevention of abuse and neglect.20, 22
A study of individual cognitive therapy for bipolar disorder showed positive
outcomes at 1 - year follow - up, but the benefits were reduced over time, suggesting the need for booster sessions
to sustain the gains.19 As with many forms of therapy, CBT has been found
to be more successful in reducing relapse in the depressive pole compared with the manic pole.30 A
large randomised trial of CBT showed no
difference between CBT and treatment as usual, when all participants were included in the analyses.31 However, results of a post-hoc analysis suggested that CBT was effective for participants who reported fewer than 12 prior episodes of illness and were not acutely unwell when therapy began; numbers of episodes of mania rather than depression seemed
to predict treatment response.32 Such data can help guide the clinical application of CBT for bipolar patients.