Sentences with phrase «large genomes»

The method can be adapted for use in large genome centers or small academic laboratories.

She said she will be interested to see whether the results are replicated in even larger genome databases — and whether additional variants will be identified.

But the assembly of such large genomes is a «never ending story,» and there is still room for improvement.

A typical virus is about a million times smaller in volume than a bat blood cell, so one challenge is sifting the evidence of viral genetic material from the background of more abundant cells with larger genomes.

That will be a boon to a wide variety of plant biologists, who expect that the rice genome will help them understand the much larger genomes of corn, wheat, and other cereals and who can now request to use the Monsanto data while waiting for the completed genome.

African populations harbour the greatest genetic diversity and have the highest per capita health burden, yet they are rarely included in large genome studies of disease association.

But Venter plans to scale up this process by combining many 5000 - base pieces to make larger genomes; IBEA's ultimate goal is to produce a small bacterial cell from scratch.

The authors of the paper, which appears in the 29 August issue of PLoS Genetics, work on large genome - wide association studies.

Unfortunately, Aedes has proved to have a technically complex and extremely large genome — one third the size of the human genome.

Those rings form a mesh that can withstand intense pressures and explain why herpesviruses pack their exceptionally large genomes into their capsids without the capsid breaking under pressure.

«In the past year, there have been several successful large genome - wide association studies of reproductive behaviors; in that context, I think this study is particularly important because of the immediate clinical relevance of gestational timing,» says David Hinds, PhD, 23andMe Principal Scientist and Statistical Geneticist, who helped to co-author the paper.

Giant viruses are characterized by disproportionately large genomes and virions that house the viruses» genetic material.

Pines (Pinus) diverged from spruces (Picea), their closest relatives, 85 MYA and possess larger genomes on average, estimated between 22 and 32 Gbp (Guillet - Claude et al. 2004; Willyard et al. 2007).

Importantly, the signatures of selection for an optimal genome size are not always consistent; the Chinese tree shrew has a high metabolic rate but a relatively large genome of 2.86 GB [13].

The random BAC fingerprinting technique has rapidly become the method of choice for mapping and sequencing the comparatively large genomes of other eukaryotic organisms, including humans.

ASHG 2016: Researchers Perform Large Genome - wide Analysis of Multiple Sclerosis ASHG Press Release — October 18, 2016

Scientists have now analyzed the DNA sequence of the California two - spot octopus (Octopus bimaculoides) and found an unusually large genome.

Success of this project will provide answers to a number of major evolutionary questions, and will help develop innovative third - generation sequencing approaches for small organisms with large genomes, said Johanna Cannon.

Knowing where those genes are in Arabidopsis will help researchers to locate their counterparts in plants with much larger genomes.

«DNA markers distinguish between harmless, deadly bacteria: Large genome study IDs potential virulence factors to discriminate new species.»

Due to ubiquitous repeats in large genomes and the inability of short sequences to uniquely and unambiguously characterize them, the short read length limits applicability for de novo sequencing.

It paves the way for assembly of even larger genomes,» said Mark Johnston, Editor - in - Chief of the journal GENETICS.

«At the end of the day, it is really about putting the foundation in place to write much larger genomes than we are presently able to, and to recognize that these technologies are coming very quickly whether we are ready for them or not,» Hessel says.

A Dec. 19 article in Nature Genetics highlights the undertaking, which is the largest genome - wide association study of primary sclerosing cholangitis to date and a step toward providing breakthrough treatments for the unmet needs of primary sclerosing cholangitis patients.

«Discoveries from largest genome - wide study of chronic liver disease.»

The Continental Origins and Genetic Epidemiology Network (COGENT) consortium conducted the research, which is the largest genome - wide association study of blood pressure in individuals of African ancestry.

Their findings, part of the largest genome wide study, were published in two papers today in the journal Nature.

While such machines hint at a future where individual labs sequence large genomes, Schloss emphasizes that large centers will continue to play a role in improving technologies and their uses and developing analytical tools for genome projects.

The largest genome - wide study of its kind has determined how much five major mental illnesses are traceable to the same common inherited genetic variations.

Decoding such a large genome calls for the generation of large datasets that then have to be processed with bioinformatics.

Japanese researchers have built a large genome from two existing bacterial chromosomes.

Before its advent, researchers often used maize, but maize has a long life cycle and a large genome, limiting its utility.

Yet it has a large genome — roughly ten times the size of a human's — which can make it challenging to study in some respects.

Like computer memory, genome sequencing capacity has been rising exponentially and decreasing in cost, making possible the deciphering of ever - larger genomes.

For the study, the researchers analyzed two large genome - wide association studies of migraine and heart disease.

The massive genome of the loblolly pine — around seven times bigger than the human genome — is the largest genome sequenced to date and the most complete conifer genome sequence ever published.

Its 22 - Gb genome size, makes it the largest genome sequenced and assembled to date.

And the marbled lungfish — a living piece of evolutionary history with the largest genome of any animal — is also rated as of least concern, despite being commonly eaten by humans.

Researchers at Brigham Young University and Rutgers University have developed a protocol that highlights the utility of this technique in plant taxa with much larger genomes, such as maize.

However, its large genome was too cumbersome for conventional whole - genome shotgun sequencing, which sequences short fragments of the genome and then stitches the results together.

Using a single pollinated pine seed, the team assembled the largest genome ever sequenced: 22.18 billion base pairs, more than seven times longer than the human genome.

The large genome size of the octopus was previously believed to be the result of whole genome duplication events, which can also be seen in the genomes of vertebrates, including humans.

At the same time, large genome - wide association studies (GWAS), which analyzed gene sequences from thousands of people, have found evidence suggesting that schizophrenia arises from the combined effects of many genes and not from a defect in any single gene.

Lane believes the crucial step in the evolution of the eukaryotes was acquiring mitochondria, which would have provided the energy to develop more complicated cellular processes and acquire a larger genome.

They also noticed that the new virus, named Bacillus phage Tsamsa, is unusually large, with a giant head, a long tail and a large genome, placing it among the largest known bacteriophages.