Sentences with phrase «large impact in the future»

«CSS hasn't been proven on the scale that it needs to be proven on for the sector where it would be used if it's to make a large impact in the future,» Lucky said.

Not exact matches

Even if your financial situation is solid, you can worry about large, sudden expenses, or about the impact of rising costs in the future.

If Barcelona or Catalonia lost the presence of large anchor companies, that would have an impact on the startup ecosystem, since large companies are customers and sources of talent and future founders,» he wrote, but the strong pace of acquisitions seems to point in the opposite direction.

While the impact on the R&D tax credit would mostly impact large public companies at first, those changes will over time play a role in how future startups spend money on innovation.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Join us on May 10th at Greentown Labs, the largest cleantech startup incubator in the U.S., to hear a variety of success stories and lessons learned, meet organizations at the forefront of impact investing, and see curated group of startups from the Greentown Labs community share how their innovations are impacting our clean energy future.

Unfortunately, conventional production has resulted in significant negative environmental and social impact, including large - scale deforestation that's endangering the future of orangutans.

The business cases for larger projects and 53 bids for smaller schemes have now been submitted and successful projects are due to be announced in the summer Mr Baker also highlighted the way the Localism Bill would impact on future funding streams.

Although representatives of the candidates denied the issue had a large impact, Mr. Brown said in an interview on Friday that Mr. Weprin's defeat was evidence that gay rights advocates were mistaken when they assured lawmakers who voted for same - sex marriage that they would not be hurt by their votes in future campaigns.

Kasper said the city's future plans may be effected by the «rapid pace of projects» related to revitalization efforts, noting that local lawmakers are hoping to do a lot of financial planning in advance to support city departments as the larger workload — along with other unknown impacts of the Downtown Revitalization Initiative (DRI)-- are levied onto their departments.

These maps, with more than 50,000 pixels, show surprisingly large local variation in trait values that could significantly impact future carbon cycle calculations produced by Earth System models (ESMs).

In fact, increasing levels of CO2 in the atmosphere — now roughly 392 parts per million and rising — may be fertilizing the rainforest and preventing even greater impacts from reduced rainfall, although this question, Davidson and his colleagues wrote in the review, «may be one of the largest unknowns for the future of the Amazon forests.&raquIn fact, increasing levels of CO2 in the atmosphere — now roughly 392 parts per million and rising — may be fertilizing the rainforest and preventing even greater impacts from reduced rainfall, although this question, Davidson and his colleagues wrote in the review, «may be one of the largest unknowns for the future of the Amazon forests.&raquin the atmosphere — now roughly 392 parts per million and rising — may be fertilizing the rainforest and preventing even greater impacts from reduced rainfall, although this question, Davidson and his colleagues wrote in the review, «may be one of the largest unknowns for the future of the Amazon forests.&raquin the review, «may be one of the largest unknowns for the future of the Amazon forests.»

They argue that while large public investments in dams and flood defences, for example, must account for the possibilities of how weather might change in the future, this should not prevent short - term thinking to address more immediate vulnerability to inevitable high - impact weather events.

The ability to manufacture proteins, which at present are very difficult or even impossible to produce, in large quantities and in their native form, rapidly and inexpensively, will have an enormous impact in all sectors of biology (biotechnology, nutrition, pharmacy, human and animal health care, and, in the near future, nanotechnology).

The models also projected an increase in intensity of the ARs, meaning an AR impacting the UK in the future is projected to deliver more moisture, potentially causing larger precipitation totals.

With this study we could show that small changes in one area can have large impacts in remote places, something that should be considered in future assessments of climate projections.»

A new integrated climate model developed by Oak Ridge National Laboratory and other institutions is designed to reduce uncertainties in future climate predictions as it bridges Earth systems with energy and economic models and large - scale human impact data.

A new integrated computational climate model developed to reduce uncertainties in future climate predictions marks the first successful attempt to bridge Earth systems with energy and economic models and large - scale human impact data.

This investment with the SFI Research Centre IPIC will enable us to combine our expertise and utilise Tyndall's state of the art facilities to develop ground breaking early stage technologies, which will not only have a huge impact on the future architecture design of large data centres, but will also improve the power and computational capacity of new consumer devices and provide robust sensing solutions in the autonomous vehicles and consumer device sectors as well as others.

Thanks to the volunteers who are running weather@home on their personal computer, a large number of present and future drought events in the UK are being created within the project «MaRIUS» (Managing the Risks, Impacts and Uncertainties of drought and water Scarcity).

Our ultimate goal is meaningful change in policy and practice that produces substantially larger impacts than current best practices on the learning capacity, health, and future economic and social mobility of vulnerable young children.

In an article that appeared in Ed Next in 2004, Chris Berry traced the decline and rebirth of small schools in America and looked at the impact of smaller schools on students» future earnings over the course of the 20th century, as the movement to consolidate small schools into larger schools greIn an article that appeared in Ed Next in 2004, Chris Berry traced the decline and rebirth of small schools in America and looked at the impact of smaller schools on students» future earnings over the course of the 20th century, as the movement to consolidate small schools into larger schools grein Ed Next in 2004, Chris Berry traced the decline and rebirth of small schools in America and looked at the impact of smaller schools on students» future earnings over the course of the 20th century, as the movement to consolidate small schools into larger schools grein 2004, Chris Berry traced the decline and rebirth of small schools in America and looked at the impact of smaller schools on students» future earnings over the course of the 20th century, as the movement to consolidate small schools into larger schools grein America and looked at the impact of smaller schools on students» future earnings over the course of the 20th century, as the movement to consolidate small schools into larger schools grew.

Relatively small improvements in students» educational performance can have large impacts on a nation's future economic well - being.

Relatively small improvements in students» educational performance can have large impacts on a nation's future economic well - being, according to The High Cost of Low Educational Performance: The Long - Run Economic Impact of Improving PISA Outcomes.

Such statements reflect the current views of Barnes & Noble with respect to future events, the outcome of which is subject to certain risks, including, among others, the general economic environment and consumer spending patterns, decreased consumer demand for Barnes & Noble's products, low growth or declining sales and net income due to various factors, possible disruptions in Barnes & Noble's computer systems, telephone systems or supply chain, possible risks associated with data privacy, information security and intellectual property, possible work stoppages or increases in labor costs, possible increases in shipping rates or interruptions in shipping service, effects of competition, possible risks that inventory in channels of distribution may be larger than able to be sold, possible risks associated with changes in the strategic direction of the device business, including possible reduction in sales of content, accessories and other merchandise and other adverse financial impacts, possible risk that component parts will be rendered obsolete or otherwise not be able to be effectively utilized in devices to be sold, possible risk that financial and operational forecasts and projections are not achieved, possible risk that returns from consumers or channels of distribution may be greater than estimated, the risk that digital sales growth is less than expectations and the risk that it does not exceed the rate of investment spend, higher - than - anticipated store closing or relocation costs, higher interest rates, the performance of Barnes & Noble's online, digital and other initiatives, the success of Barnes & Noble's strategic investments, unanticipated increases in merchandise, component or occupancy costs, unanticipated adverse litigation results or effects, product and component shortages, the potential adverse impact on the Company's businesses resulting from the Company's prior reviews of strategic alternatives and the potential separation of the Company's businesses, the risk that the transactions with Microsoft and Pearson do not achieve the expected benefits for the parties or impose costs on the Company in excess of what the Company anticipates, including the risk that NOOK Media's applications are not commercially successful or that the expected distribution of those applications is not achieved, risks associated with the international expansion contemplated by the relationship with Microsoft, including that it is not successful or is delayed, the risk that NOOK Media is not able to perform its obligations under the Microsoft and Pearson commercial agreements and the consequences thereof, risks associated with the restatement contained in, the delayed filing of, and the material weakness in internal controls described in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended April 27, 2013, risks associated with the SEC investigation disclosed in the quarterly report on Form 10 - Q for the fiscal quarter ended October 26, 2013, risks associated with the ongoing efforts to rationalize the NOOK business and the expected costs and benefits of such efforts and associated risks and other factors which may be outside of Barnes & Noble's control, including those factors discussed in detail in Item 1A, «Risk Factors,» in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended April 27, 2013, and in Barnes & Noble's other filings made hereafter from time to time with the SEC.

Such statements reflect the current views of Barnes & Noble with respect to future events, the outcome of which is subject to certain risks, including, among others, the effect of the proposed separation of NOOK Media, the general economic environment and consumer spending patterns, decreased consumer demand for Barnes & Noble's products, low growth or declining sales and net income due to various factors, possible disruptions in Barnes & Noble's computer systems, telephone systems or supply chain, possible risks associated with data privacy, information security and intellectual property, possible work stoppages or increases in labor costs, possible increases in shipping rates or interruptions in shipping service, effects of competition, possible risks that inventory in channels of distribution may be larger than able to be sold, possible risks associated with changes in the strategic direction of the device business, including possible reduction in sales of content, accessories and other merchandise and other adverse financial impacts, possible risk that component parts will be rendered obsolete or otherwise not be able to be effectively utilized in devices to be sold, possible risk that financial and operational forecasts and projections are not achieved, possible risk that returns from consumers or channels of distribution may be greater than estimated, the risk that digital sales growth is less than expectations and the risk that it does not exceed the rate of investment spend, higher - than - anticipated store closing or relocation costs, higher interest rates, the performance of Barnes & Noble's online, digital and other initiatives, the success of Barnes & Noble's strategic investments, unanticipated increases in merchandise, component or occupancy costs, unanticipated adverse litigation results or effects, product and component shortages, risks associated with the commercial agreement with Samsung, the potential adverse impact on the Company's businesses resulting from the Company's prior reviews of strategic alternatives and the potential separation of the Company's businesses (including with respect to the timing of the completion thereof), the risk that the transactions with Pearson and Samsung do not achieve the expected benefits for the parties or impose costs on the Company in excess of what the Company anticipates, including the risk that NOOK Media's applications are not commercially successful or that the expected distribution of those applications is not achieved, risks associated with the international expansion previously undertaken, including any risks associated with a reduction of international operations following termination of the Microsoft commercial agreement, the risk that NOOK Media is not able to perform its obligations under the Pearson and Samsung commercial agreements and the consequences thereof, the risks associated with the termination of Microsoft commercial agreement, including potential customer losses, risks associated with the restatement contained in, the delayed filing of, and the material weakness in internal controls described in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended April 27, 2013, risks associated with the SEC investigation disclosed in the quarterly report on Form 10 - Q for the fiscal quarter ended October 26, 2013, risks associated with the ongoing efforts to rationalize the NOOK business and the expected costs and benefits of such efforts and associated risks and other factors which may be outside of Barnes & Noble's control, including those factors discussed in detail in Item 1A, «Risk Factors,» in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended May 3, 2014, and in Barnes & Noble's other filings made hereafter from time to time with the SEC.

So, if you recently (like say within the last year) opened a store card for a large purchase and paid it off, and probably won't be using that card in the future, you might want to cancel that account, as the positive effect on your score because it helps your ratios is probably outweighed by the negative impact on your score because it is a new account.

A change in interest rates has a larger impact on cash flows farther into the future because the effect gets compounded for each year.

Investments in futures involve leverage, which means a small percentage of assets invested in futures can have a disproportionately large impact on the Fund.

«The Impact of Automatic Enrollment in 401 (k) Plans on Future Retirement Accumulations: A Simulation Study Based on Plan Design Modifications of Large Plan Sponsors» [April 2010, EBRI Issue Brief # 341]

Stillness in Motion — Cloud Cities is part of Saraceno's larger, long - term project titled Aerocene, the artist's vision for a future era in which humanity minimizes the impact on the planet's fossil - fuel resources, and instead resides in collective airborne cities.

The exhibition is part of Saraceno's larger, long - term project titled «Aerocene», the artist's vision for a future era in which humanity minimizes the impact on the planet's fossil - fuel resources, and instead resides in collective airborne cities.

Effects of harvest and climate change on polar marine ecosystems: case studies from the Antarctic Peninsula and Hudson Bay C Hoover — 2012 — circle.ubc.ca... Future simulations of the Antarctic Peninsula identify large reductions in ecosystem biomass of all species due changes in environmental conditions and an overall reduction in krill, with minimal ecosystem impacts from harvest.

In contrast to Michaels et al., who exclusively emphasize uncertainties that lead to smaller future changes, uncertainties are noted that could lead to either smaller or larger changes in future intensities of hurricanes than those summarized in the original study, with accompany in smaller or larger societal impactIn contrast to Michaels et al., who exclusively emphasize uncertainties that lead to smaller future changes, uncertainties are noted that could lead to either smaller or larger changes in future intensities of hurricanes than those summarized in the original study, with accompany in smaller or larger societal impactin future intensities of hurricanes than those summarized in the original study, with accompany in smaller or larger societal impactin the original study, with accompany in smaller or larger societal impactin smaller or larger societal impacts.

The actual impacts would be much larger, since the US (and global) economy will be larger in the future.

It appears that Pruitt instructed the EPA career staff to make assumptions grossly unfavorable to the CPP in order to calculate the largest possible negative economic impact; for example, the RIA models scenarios that minimize the CPP's reductions in unhealthy air pollutants, inflate the costs of compliance, only count the climate benefits of CO2 reductions in the US, and greatly discount the future benefits of lower global temperatures.

The first step in being truly objective is to openly acknowledge the large degree of uncertainty which exists today on the relative importance of natural and anthropogenic climate forcing components and, hence, on the validity of any long - term projections of future impact of anthropogenic factors.

As Prof Peirs Forster, an IPCC lead author, wrote of the seminal study he led in 2012: «Food Security: Near future projections of the impact of drought in Asia» «Research released today shows that within the next 10 years large parts of Asia can expect increased risk of more severe droughts, which will impact regional and possibly even global food security.

Methane is an important part of the anthropogenic radiative forcing Methane emissions have a direct GHG effect, and they effect atmospheric chemistry and stratospheric water vapour which have additional impacts natural feedbacks involving methane likely to be important in future — via wetland response to temperature / rain change, atmospheric chemistry and, yes, arctic sources There are large stores of carbon in the Arctic, some stored as hydrates, some potentially convertible to CH4 by anaerobic resporation [from wikianswers: Without oxygen.

So [edited] I think that the results of Vecchi and Soden do put a dent in the hypothesis that human industrial emissions are largely responsible for the observed increase in Atlantic tropical cyclones and that they will have a larger impact into the future [edited]- Chip Knappenberger to some degree, funded by the fossil fuels industry since 1992

The future of glaciers and associated runoff is projected for 56 large drainage basins globally, with glacier wastage impacting on runoff and water resources even in basins with limited glacier cover.

More on Hydropower: Hydropower Not Likely Under New Climate Future Run Your Home on Small - Scale Hydropower This is Big: US Could Double Hydropower Capacity With Minimal Impact, Says Steven Chu Micro-Hydro Power: Small - Scale, Large Impact China Mulls Building Dams in Southern Tibet China Builds Dam on Indus, Doesn't Tell Pakistan

And yet, despite a long history of scientific warnings (please see Footnote 30 for a detailed description30), the many current ecological and economic impacts and crises, the future risks and dangers, the large number of international meetings and conferences on the urgent need for climate policies and measures, and the adoption of some national and regional climate policies, growth in global CO2 emissions from fossil fuels and cement has not only remained strong but is actually accelerating.

More ominously, a climate with large magnitude natural long - term variability in general is a climate very sensitive to imposed forcings, raising concerns about extreme impacts due to future climate change).

It might salve a conscience but is meaningless in the larger picture of future impacts.

The change had an immediate impact, especially on those cases where settlement was imminent and where there was a large element of future loss, increasing the value in some cases involving catastrophic injury by millions of pounds overnight.

That's his hope as he moves into the future, which holds what he describes as «some rather large and sophisticated intellectual property disputes,» the kind that he says will «impact the relative market position or standing of various players in the telecom industry.»

Besides detailing her role at The Deltic Group, her leadership in the company's operations, and the challenges of being the Head of Legal in such a large entertainment group, Helen discusses the establishment, progression, impact and future of the Licensing Act, with some reference to Brexit and the changing landscape of today's night life culture.

Paydays aren't as large and vacations aren't as long, but the millennial traveler is having a profound impact on how all Americans will travel in the future, according to an analysis of travel throughout the 2017 peak season by Allianz Global Assistance USA.

Midwest Steel Blanking (Lombard, IL) 07/2004 — 08/2008 Director of Operations • Oversaw daily operations and management of 40 employees including 2 project managers • Served as an advisor to the President on all critical and strategic issues • Led presentations to banks, governmental agencies, potential investors, and large volume customers • Oversaw production, maintenance, quality control, and all other dealings with all outside vendors • Negotiated all insurance policies and contracts concerning account receivables and insurance related claims • Developed the ISO 9000 quality manual and OSHA safety awareness programs, training, and documentation • Trained future managers of the company in professional skills, managerial decision making, and business communications • Designed and implemented a new inventory control systems for managing raw - material and finished - goods • Ensured cost control limiting the direct expenses incurred and indirect impacts such as inefficiencies, downtime, and waste • Over a 3 year period, reduced the account receivables insurance premium from $ 55K to $ 13K / year • Renegotiated all other insurance contracts for better coverage and reduced premiums by 20 % • Reduced «outside parts manufacturing» cost by 50 % • Maintained the cost of all supplies at the 2004 levels • Instituted production reporting and operational data analyses for decision making • Reduced down time by 60 %, overall operation's cost by 4.5 %, and scrap generation by 3 % • Developed ISO 9001 quality manuals and handled external annual audits • Introduced safety procedures and training programs