Sentences with phrase «large number of changes»

The Criminal Procedure (Amendment No 3) Rules 2007 (SI 2007/3662) bring into force a large number of changes to the existing rules.

This interest will likely continue to grow since a large number of changes in climate phenomena remain uncertain, even when fundamental mechanisms are relatively well understood (e.g., changes in monsoons, heat waves, cyclones).

We've been following all of the community feedback and we've made a large number of changes.

The plan will set a large number of changes in place, and aims not only to fix the current...

The publishing industry has seen a large number of changes with the advancement of technology.

Last week, Digital Home reported that IPTV television provider MTS had begun rolling out a large number of changes to its television line - up along with more than 25 new channels.

He said the combination of a «large number of changes» in a «small space of time» along with a «perceived sense of it all happening in a piecemeal fashion» left schools having to «make it up as we go along».

Association of School and College Leaders general secretary Brian Lightman said: «School and college leaders are deeply unhappy about the way in which a large number of changes to exams have been introduced in a short space of time in a piecemeal manner.

Somehow, in projecting to the future, Whittle posits a large number of changes in the basic institutions for delivering education, education research, and education personnel, based on the «success» of the EMOs, especially Edison.

A very large number of changes have been discovered in HD model mice and then subsequently observed in human HD patients, suggesting the mice are useful research tools, even if they don't really have Huntington's disease.

I'm not in favour of large number of changes in one window.

Arsenal made a large number of changes to their starting line - up for the trip to Southampton today, but Arsene Wenger clearly has no doubts over his selection after the opening 45.

Not exact matches

That trend shows no sign of changing as automation becomes more widespread — and many predict the number of jobs will shrink by a large number.

In a recent research note, he pointed to the possibility, based on Apple's reported hiring of a large number of auto industry veterans, of Apple changing gears entirely and building a car.

In addition to the large - scale alterations at its VIP locations, the company made a number of changes to its seating:

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

When we talked to Farhan Siddiqi a few months ago, he noted that trouble with making big changes at places like McDonald's — restaurants that serve unaccountably large numbers of consumers worldwide daily — is a bit like trying to turn a battleship around.

A number of operational features were required to implement such an overnight reverse repo, or ON RRP, facility: It would need same - day settlement; 16 the operation would need to be run predictably, every day, and as late in the day as possible, to give lenders time to bargain with other counterparties using the outside option of investing with the Federal Reserve; 17 an appropriate spread below IOR would be required to ensure that the facility neither induced large changes in the structure of money markets nor lost the ability to support interest rate control; 18 and the operations would need enough unused capacity that lenders could credibly propose to leave borrowers that did not offer an adequate interest rate.19

That's a staggering number considering all of the changes and unknowns that still exist with one of the largest changes to health care our country has ever seen.

So, a number of firms large and small have made changes to their fee structure in part of fiduciary rule this was a rule crafted by the Obama administration and came into effect last April.

«Given the large numbers at play, it is going to take meaningful time to see big numbers in terms of board diversity percentages but the pace of change is accelerating,» said Cassidy, whose Boardlist now has nearly 4,000 members.

There are a large and increasing number of loan options available to business owners, and we expect to see even more changes and new players in the coming years.

Similarly, the owners of the smallest businesses surveyed are more likely to say the income sprinkling changes are fair than unfair, while majorities of those with larger numbers of employees say such changes are unfair:

These are noteworthy changes to the company's lending policy, and they could affect a large number of first - time home buyers who otherwise might not qualify for a mortgage loan.

These changes to the essential service regime will have the effect of meaning that a larger number of public servants can not exercise their right to strike.

The countries with local tellers will be changing rapidly for the next several weeks as we process the very large number of registrations we're getting.

One quick change action can often be enough, but when you do it in droves, and you offer a large amount of them, the better the chance that what you say will impact the largest number of people.

Additionally, the legislation left in place a large number of legal requirements in the ACA, including the essential benefits package requirements, the prohibition on insurers denying or charging more for coverage for those pre-existing conditions, the limits on «medical loss ratios,» and other changes that do not have a direct budgetary effect.

Inspired by Obama and undeterred by parliamentary scandals, as yet uncommitted to any particular party, but increasingly aware that few arenas have the opportunity to create greater positive change for large numbers of people than the righteous use of political power, he wants to study politics, philosophy and economics.

But this growth and the change that has resulted from large numbers of refugees converting to Christianity can present challenges for smaller churches.

Friedman thinks a major change may be under way, citing the large number of younger Jewish intellectuals and writers who identify themselves as conservative.

This could change, of course, if large numbers of the newly ordained insist on preaching sermons on contraception every Sunday.

And Dean Hoge has observed that «in general, the number of people who have left because of changes in the church is not as large as the number who have left because of lack of changes.»

Ben Armstrong still states that «penny for penny, per capita studies indicate there is no better way to reach the largest number of people with the life - changing news of Jesus Christ than through radio and television.»

either way I seriously suspect we will be linked with a large number of players and the only one we will see in an Arsenal shirt come august will be Granit We nger has NOT changed in anyway and has already stated that Giroud will lead the line next season which rules out Lewondowski, Aubamayang, Higauin and any real top signings and IF France win the euro (wich will be no real indication of anything much) Wenger will sing Giroud priases to the heavens and state that we have the top striker in europe.

This is an incredibly difficult question to answer for a variety of reasons, most importantly because over the years our once vaunted «beautiful» style of play has become a shadow of it's former self, only to be replaced by a less than stellar «plug and play» mentality where players play out of position and adjustments / substitutions are rarely forthcoming before the 75th minute... if you look at our current players, very few would make sense in the traditional Wengerian system... at present, we don't have the personnel to move the ball quickly from deep - lying position, efficient one touch midfielders that can make the necessary through balls or the disciplined and pacey forwards to stretch defences into wide positions, without the aid of the backs coming up into the final 3rd, so that we can attack the defensive lanes in the same clinical fashion we did years ago... on this current squad, we have only 1 central defender on staf, Mustafi, who seems to have any prowess in the offensive zone or who can even pass two zones through so that we can advance play quickly out of our own end (I have seen some inklings that suggest Holding might have some offensive qualities but too early to tell)... unfortunately Mustafi has a tendency to get himself in trouble when he gets overly aggressive on the ball... from our backs out wide, we've seen pace from the likes of Bellerin and Gibbs and the spirited albeit offensively stunted play of Monreal, but none of these players possess the skill - set required in the offensive zone for the new Wenger scheme which requires deft touches, timely runs to the baseline and consistent crossing, especially when Giroud was playing and his ratio of scored goals per clear chances was relatively low (better last year though)... obviously I like Bellerin's future prospects, as you can't teach pace, but I do worry that he regressed last season, which was obvious to Wenger because there was no way he would have used Ox as the right side wing - back so often knowing that Barcelona could come calling in the off - season, if he thought otherwise... as for our midfielders, not a single one, minus the more confident Xhaka I watched played for the Swiss national team a couple years ago, who truly makes sense under the traditional Wenger model... Ramsey holds onto the ball too long, gives the ball away cheaply far too often and abandons his defensive responsibilities on a regular basis (doesn't score enough recently to justify): that being said, I've always thought he does possess a little something special, unfortunately he thinks so too... Xhaka is a little too slow to ever boss the midfield and he tends to telegraph his one true strength, his long ball play: although I must admit he did get a bit better during some points in the latter part of last season... it always made me wonder why whenever he played with Coq Wenger always seemed to play Francis in a more advanced role on the pitch... as for Coq, he is way too reckless at the wrong times and has exhibited little offensive prowess yet finds himself in and around the box far too often... let's face it Wenger was ready to throw him in the trash heap when injuries forced him to use Francis and then he had the nerve to act like this was all part of a bigger Wenger constructed plan... he like Ramsey, Xhaka and Elneny don't offer the skills necessary to satisfy the quick transitory nature of our old offensive scheme or the stout defensive mindset needed to protect the defensive zone so that our offensive players can remain aggressive in the final third... on the front end, we have Ozil, a player of immense skill but stunted by his physical demeanor that tends to offend, the fact that he's been played out of position far too many times since arriving and that the players in front of him, minus Sanchez, make little to no sense considering what he has to offer (especially Giroud); just think about the quick counter-attack offence in Real or the space and protection he receives in the German National team's midfield, where teams couldn't afford to focus too heavily on one individual... this player was a passing «specialist» long before he arrived in North London, so only an arrogant or ignorant individual would try to reinvent the wheel and / or not surround such a talent with the necessary components... in regards to Ox, Walcott and Welbeck, although they all possess serious talents I see them in large part as headless chickens who are on the injury table too much, lack the necessary first - touch and / or lack the finishing flair to warrant their inclusion in a regular starting eleven; I would say that, of the 3, Ox showed the most upside once we went to a back 3, but even he became a bit too consumed by his pending contract talks before the season ended and that concerned me a bit... if I had to choose one of those 3 players to stay on it would be Ox due to his potential as a plausible alternative to Bellerin in that wing - back position should we continue to use that formation... in Sanchez, we get one of the most committed skill players we've seen on this squad for some years but that could all change soon, if it hasn't already of course... strangely enough, even he doesn't make sense given the constructs of the original Wenger offensive model because he holds onto the ball too long and he will give the ball up a little too often in the offensive zone... a fact that is largely forgotten due to his infectious energy and the fact that the numbers he has achieved seem to justify the means... finally, and in many ways most crucially, Giroud, there is nothing about this team or the offensive system that Wenger has traditionally employed that would even suggest such a player would make sense as a starter... too slow, too inefficient and way too easily dispossessed... once again, I think he has some special skills and, at times, has showed some world - class qualities but he's lack of mobility is an albatross around the necks of our offence... so when you ask who would be our best starting 11, I don't have a clue because of the 5 or 6 players that truly deserve a place in this side, 1 just arrived, 3 aren't under contract beyond 2018 and the other was just sold to Juve... man, this is theraputic because following this team is like an addiction to heroin without the benefits

It would not be the first time that Arsenal did this and after seeing it time and time again, including last season, a large number of Arsenal fans were convinced we needed a change at the top.

Sauber is the final team to showcase what they've done with the rule changes, going for larger numbers on the nose and the driver name abbreviations at the top of the shark fin.

Part of that decrease in scoring is due to the large number of rule changes implemented prior to last season's game.

By the time a newborn is a week old, he should be having a fairly large number of diaper changes per day.

Clevamama Hannah tote baby changing bag comes with quilted shoulder straps to create a more convenient, chic city bag, it is super lightweight and has wide opening for easy access to a generous number of organiser pockets and compartments as well as a large zip close pocket

Other factors that can change your breast appearance more than breastfeeding includes BMI, age, history of smoking, large pre-pregnancy breast size and number of pregnancies.

The Government acknowledged that a large number of respondents to the consultation opposed the change, but insisted it was committed to «taking this important step for religious freedom and LGB rights».

The next major change came in the costs reported for the 2011 - 12 financial year, when another large (but unknown) number of staff were classified out of administration, mostly from the Department for Work and Pensions (DWP), and HM Revenue and Customs (HMRC).

Whilst these blogs are popular - in terms of unique visitor numbers (and before Unity has a go at me, I know there are weaknesses in those numbers)- they tend to be written by people who write about a large number of issues and climate change is not their principle topic (or even one that they discuss very often).

Moreover, while moratoria on executions should be welcomed, if they are not accompanied by a change in judicial practice, long - term moratoria result in a large number of people languishing on «death row», a condition which may amount to cruel, inhuman or degrading treatment.

We may assume that a relatively large number of voters will choose one of these three party lists and put it into the election box without changes, for example 42,000 choose party A, 32,000 choose party B and 11,000 choose party C.

Democrats said the changes in Smith's bill would likely lead to a large number of women losing access to comprehensive health insurance coverage because small business owners would have an incentive to offer plans that don't cover abortion.

Having a large number of people threatened by poverty creates a large incentive for these people to change the laws in their favor, even if they profited from them earlier on.

The party advisor said: «The NSC is the largest of a number of reforms to the central machinery of the security apparatus, it's mainly a change in Cabinet Office.