Sentences with phrase «large number of combinations»

Our model building program qFit uses mixed integer quadratic programming (MIQP) to evaluate an extremely large number of combinations of sidechain conformers and backbone fragments to locally explain the electron density.

IG is the primary binary broker in Singapore, it provides direct market access, small spreads between currencies and a large number of combinations of forex pairs.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

But the attempt to reduce living systems to such, that is to say formal reductionism, fails in part because the number of possible combinations or classifications is generally immensely larger than the number of degrees of freedom.

They are suitable for men and women, and thanks to the large number of different colour combinations everybody can find the model that fits his or her style the most.

Given the large number of children who were co-sleeping yet did not succumb to SIDS, the authors wondered whether co-sleeping alone had put children at risk for sudden death or a combination of behaviors.

Using a combination of behavioral and neuroimaging methods, he and his colleagues examine how children develop foundational number - processing abilities, such as the ability to judge which of two numbers is larger or to estimate numbers» position on a number line; why these basic cognitive processes sometimes go awry; and how to help children with serious deficits in numerical processing.

The nanopores can be filled with specific cytokines, oligonucleotides, large protein antigens, or any variety of drugs of interest to allow a vast number of possible combinations to treat a range of infections.

«We wanted to see whether very - large - scale screening across a diverse collection of cancer cell lines and a large number of drugs could yield new combinations for patients with cancer,» says Adam Friedman, MD, PhD, of the CBRC and the MGH Cancer Center, who led the study.

In a presentation of early clinical trial data to the 20th Annual Scientific Meeting of the Society for Neuro - Oncology, physician scientists from the University of New Mexico Comprehensive Cancer Center reported that a large number of study participants responded well to the drug combination.

The Keck / DEIMOS combination is the only one in the world capable of making these velocity measurements for large numbers of Andromeda stars.»

take a lead in developing the next generation of cancer cell lines and use cell lines to systematically explore in vitro sensitivity to large numbers of anticancer drugs and drug combinations in order to inform choice of cancer types for early drug trials.

We conclude that the large number of mouse mutants and human de novo mutations may be due to the combination of the Chd7 gene being a large target and the fact that many heterozygous carriers of the mutations are viable individuals with a readily detectable phenotype.

As outlined below, we used a microfluidic quantitative PCR (qPCR) system to elucidate the gene expression profiles of individual human oocytes and small numbers of cumulus cells using a combination of a large number of samples and targets [12], and then extended our studies via the use of parthenogenesis, in conjunction with gene expression profiling, as a functional assay of cytoplasmic maturation of oocytes.

Then the researchers generated various mathematical combinations of the predicted chemical data to produce a large number of possible relationships between different subgroups of gold clusters.

Specifically formulated with oily and combination skin types in mind, this lightweight, oil - free BB cream helps conceal a number of skin concerns such as large pores, uneven skin tones, and visible imperfections, resulting in a complexion that appears smooth, matte, and virtually flawless.

It is a site that has a large number of members, longevity, site Here are the top 15 Most Popular Dating Sites ranked by a combination of continually updated traffic statistics.

objectives include: Year 6 objectives • solve problems involving the calculation and conversion of units of measure, using decimal notation up to 3 decimal places where appropriate • use, read, write and convert between standard units, converting measurements of length, mass, volume and time from a smaller unit of measure to a larger unit, and vice versa, using decimal notation to up to 3 decimal places • convert between miles and kilometres • recognise that shapes with the same areas can have different perimeters and vice versa • recognise when it is possible to use formulae for area and volume of shapes • calculate the area of parallelograms and triangles • calculate, estimate and compare volume of cubes and cuboids using standard units, including cubic centimetres (cm ³) and cubic metres (m ³), and extending to other units [for example, mm ³ and km ³] • express missing number problems algebraically • find pairs of numbers that satisfy an equation with 2 unknowns • enumerate possibilities of combinations of 2 variables • draw 2 - D shapes using given dimensions and angles • recognise, describe and build simple 3 - D shapes, including making nets • compare and classify geometric shapes based on their properties and sizes and find unknown angles in any triangles, quadrilaterals, and regular polygons • illustrate and name parts of circles, including radius, diameter and circumference and know that the diameter is twice the radius • recognise angles where they meet at a point, are on a straight line, or are vertically opposite, and find missing angles • describe positions on the full coordinate grid (all 4 quadrants) • draw and translate simple shapes on the coordinate plane, and reflect them in the axes • interpret and construct pie charts and line graphs and use these to solve problems • calculate and interpret the mean as an average • read, write, order and compare numbers up to 10,000,000 and determine the value of each digit • round any whole number to a required degree of accuracy and more!

He said the combination of a «large number of changes» in a «small space of time» along with a «perceived sense of it all happening in a piecemeal fashion» left schools having to «make it up as we go along».

The combination of BMW Twin Turbo Technology and High Precision Injection offers a level of performance a naturally - aspirated power unit would only be able to provide with a larger number of cylinders and extra displacement, meaning far higher weight and significantly greater fuel consumption.

«And to maximize the unique lifestyles of our Dodge customers and large number of brand enthusiasts, the complete 2010 Dodge lineup features new lifestyle packages designed and engineered to deliver outstanding value though combinations of class - leading innovation, thoughtful features, safety, technology, more power, style and, ultimately, driving excitement.»

PERFORMANCE, HANDLING Ford builds the Ranger with a large number of drivetrain combinations.

Please note: In any combination of large collections of books will be any number of duplications, sometimes of the same edition or the same title and author, but a different edition.

More shares mean less volatility because it takes a larger number of trades, a larger number of shares per trade, or a combination of both to raise or lower the stock price.

A combination of issues — including deprivation, but also religious and cultural ideas regarding neutering and the purpose and status of cats in people's homes and community — have all resulted in very large numbers of cats in need of assistance in this area.

«The distinction between compensatory and additive mortality does, however, become increasingly redundant as the number of birds killed in a given area increases: where large numbers of prey are killed, predators would probably be killing a combination of individuals with poor and good long - term survival chances.

Understand, however, that due to the large number of animals surrendered in combination with the number of stray animals picked up daily, space and time are not always guaranteed to be on your animal's side.

There is a very large number of possible combinations, and the following table only lists those most often bred deliberately.

You redeem a large number of points for a combination of a week - long stay at a hotel within the Marriott collection and airline miles to get there.

Certain combinations of abilities completely trivialize the game, enabling the character to become perpetually invincible, or generate a large number of extra turns.

With a large number of team composition, map and game mode combinations with mostly balanced hero counters and ultimates, Overwatch should keep PvP fans engaged for a very long time.

Players can use any combination of remotes, nunchuks, Classic Controllers, Pro Controllers, 3DS systems, GameCube controllers and even the GamePad to get up to the number of needed pads, and only stages really capable of managing large crowds are enabled here.

The large number of skills combinations results in an MMO game that is difficult to fully master but without an overly difficult barrier to entry.

Given that the number of possible arrangements in a deck of cards is an «astronomically large number» (see above), the program will not run through all the possible combinations of musical notes during the lifespan of planet earth — assuming constancy of electrical power to the work and other contingencies.

In this comprehensive solo exhibition, Klara Kristalova presents a combination of large - scale and small sculptures, accompanied by a number of sketches, drawings and watercolours.

The reconstruction all the way back to the year 1400 used 22 proxy data series, although some of the 22 were combinations of larger numbers of proxy series by a method known as «principal components analysis» (hereafter called «PCA» — see here).

And we have to do it on a large scale, so it involves geoengineering — preferably using a number of techniques in combination.

It is a powerful convergence of interests among a very large number of elites, including politicians who want to make it seem as though they're saving the world, environmentalists who want to raise money and get control over very large issues like our entire energy policy, media, for sensationalism, Universities and professors for grants... It is a kind of nasty combination of extreme political ideology and a religious cult all rolled into one, and it's taken over way too much of our thought process and way too much of our priorities.

In absence of that the statistical evidence must be very much stronger because the number of combinations to test is so large that it results easily to spurious conclusions.

Given the large number of data series in existence (and the nearly infinite number of combinations thereof), it would literally be impossible to attempt replication of Jones» results without explicit guidance as to which data were used in the original work.

From Dentons» latest combination to high profile hires and a larger than normal number of salacious stories, it's been a busy news week for the height of summer.

Certainly no one predicted — or could predict — that the combination of a large number of online photographs would be a formless blur of orange.

James has also advised on a number of M&A transactions involving Channel Islands businesses, including Bank Leumi on the disposal of its Jersey corporate services and banking businesses, GLI Finance (AIM) on its acquisition of peer - to - peer lending businesses Sancus Gibraltar and BMS Finance, a consortium of investors on their acquisition of the SandpiperCI group, the Channel Islands» largest retailer, JTC Group on its acquisition of the Kleinwort Benson Channel Islands funds business and Stonehage on its combination with Fleming Family & Partners to form the leading independent multi-family office in Europe, Middle East and Africa.

Merger activity slowed down slightly in 2016, at least with regard to larger combinations, while a number of large firms continued to acquire boutiques.

Robin Allen QC, Chair of the Bar Council's Equality and Diversity Committee, said: «The progress made in recruiting more female judges is to be welcomed; but there is an urgent need to increase the number of part - time salaried posts which offer a useful combination of certainty and flexibility for the large number of lawyers with caring responsibilities.

It adds up to a large but not unmanageable number of combinations.

The benefits of the large clear text massively outweigh the negatives, though — it's easy to read, and the combinations of icons, numbers and labels mean you're never in any doubt about what you're looking at.

It is the method where used to get the combination of lock and it is used to convert a random large number into the smaller number by taking some certain action

Because of this, it is really only useful if you can not make either a chronological or combination resume work for you and if you have a large number of big ticket, impressive achievements to shout about.

If you have large gaps in your work history, have been employed in a number of jobs for a short time, are a new graduate student, or are changing careers: a functional or a combination resume may be the most effective format for your resume.