Sentences with phrase «large number of trials»

Despite this large number of trials, it is still not clear whether there are clinically relevant differences between these therapies.

According to the law, the average of the results obtained from a large number of trials should be close to the expected value, and will tend to become closer as more trials are performed.»

(Long - 26 minutes) Presentation on spreadsheet to show that the normal distribution approximates the binomial distribution for a large number of trials.

There is a very large number of trials in this field and this number continues to grow.

In meta - analyses with a large number of trials, as is the case in this review, there is a strong possibility that a large number of small and possibly poor quality trials will have a substantial influence on the result.

The largest number of trials has occurred in Quebec, with Ontario coming on strong recently with a number of very significant trials and appeals.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Although Lu - PSMA - 617 put up good numbers in its small single - arm study, it still needs to outperform a physician's choice of approved treatments in a much larger global trial.

«The two largest groups containing prisoners in the camps, both numbering in the millions, were the Polish Jews and the Soviet prisoners of war (POWs) held without trial or judicial process.

«At the start of the year, we held a number of taster and trials sessions that attracted a large amount of participation.

The Term Breech Trial is the largest randomized clinical trial ever undertaken on term breech mode of delivery, and while it offered a wealth of information regarding breech birth, it also had a number of weaknesses which have been identified since its publicaTrial is the largest randomized clinical trial ever undertaken on term breech mode of delivery, and while it offered a wealth of information regarding breech birth, it also had a number of weaknesses which have been identified since its publicatrial ever undertaken on term breech mode of delivery, and while it offered a wealth of information regarding breech birth, it also had a number of weaknesses which have been identified since its publication.

You also learn about the challenges and trials of parenting a large number of children who are all going through the same things at the same time.

Finally, a Finnish trial of universal home visiting by nurses35 and two U.S. programs implemented by master's degree - level mental health or developmental clinicians have found significant effects on a number of important child behavioural problems.36, 37 Additionally, a paraprofessional home visitation program found effects on externalizing and internalizing behaviours at child age 2; however due to the large number of effects measured in this study, replication of the findings is warranted.38

In addition, there was no effect on breastfeeding duration when the pacifier was introduced at 1 month of age.280 A more recent systematic review found that the highest level of evidence (ie, from clinical trials) does not support an adverse relationship between pacifier use and breastfeeding duration or exclusivity.281 The association between shortened duration of breastfeeding and pacifier use in observational studies likely reflects a number of complex factors such as breastfeeding difficulties or intent to wean.281 A large multicenter, randomized controlled trial of 1021 mothers who were highly motivated to breastfeed were assigned to 2 groups: mothers advised to offer a pacifier after 15 days and mothers advised not to offer a pacifier.

The Feedback Intervention Trial (FIT) is the first such trial to be done in a large number of hospitals anywhere in the wTrial (FIT) is the first such trial to be done in a large number of hospitals anywhere in the wtrial to be done in a large number of hospitals anywhere in the world.

First, you will have to do the trial with a large number of people.

«If we find that lymphoscintigrams using tilmanocept are at least as good as the conventional radiocolloid tracer in identification and visualization of sentinel nodes, we would like to see a randomised clinical trial involving large numbers of patients,» says Prof de Bree.

One became scared of the police because of the large numbers of arrests and detentions without trial in the community.

More clinical trials with larger numbers of participants are needed to tease out the most effective cannabis - based therapies.

A statin drug commonly used to lower cholesterol is not effective in reducing the number and severity of flare ups from chronic obstructive pulmonary disease (COPD), according to the results of a large multicenter clinical trial designed and directed by Gerard J. Criner, MD, Director of Pulmonary and Critical Care Medicine at Temple University Hospital in Philadelphia, PA..

If animal tests go well, the next trials will be with humans, a process that involves three stages — one for safety, the next to see if the protein kills cancer in a limited number of people, and the last to turn it loose in a large group.

Young also hopes the results, which should be compiled by the end of the year, will provide enough preliminary evidence to help raise funds for a larger trial testing the use of social media to combat abuse of a broader number of substances.

To answer these questions, the scientists went in a new direction: They performed infection trials in a large number of cell cultures at different temperature levels.

«We have shown that a large number of study participants are routinely exposed to the risks of trial participation without the benefits that sharing and publishing results would have for patients in the future.

A few trials even indicated that large numbers of people learned they had harmless, but nevertheless alarming, medical abnormalities.

Yale enrolled the largest number of participants at any one site (84 of 790) for these double - blind, placebo - controlled trials that investigated the efficacy of testosterone gel for multiple outcomes, including sexual function, physical function, and vitality.

Because of the urgent needs of a large number of cancer patients, most of these gene therapy trials are directed against cancer.

Another limitation is that the trial did not select patients who were at the highest risk for developing another arterial blockage, such as those over age 65, those who have had more than one heart attack or those known to have a large number of blood clots.

The study was the first randomized - controlled trial to examine the potential benefits of the low fat diet on the management of MS.. The study found no significant differences between the two groups in brain lesions detected on MRI brain scans or on other measures of MS.. But while the number of trial participants was relatively small, study leaders believe the significantly improved fatigue symptoms merited further and larger studies of the diet.

Researchers are planning to extend the clinical trial to a much larger number of patients in a multinational study, to demonstrate not only a reduced infarct size, but also a reduced mortality in patients who receive early metoprolol during transit to hospital.

In an editorial accompanying the published article in Circulation, experts from the Technische Universität and the Munich Heart Alliance, Gjin Ndrepepa and Adnan Kastrati, affirmed that, if confirmed by a subsequent analysis of large numbers of patients, the results of METOCARD - CNIC trial are likely to lead to a change in clinical practice: «In this regard, a pharmaco - protective strategy able to reduce infarct size by 20 percent when used in conjunction with primary PCI nurtures great hope in clinical benefit.»

St. Michael's was the only site outside of the United States involved in the Phase 2 clinical trial for the drug and had the largest number of patients enrolled in the Phase 3 trial.

In a presentation of early clinical trial data to the 20th Annual Scientific Meeting of the Society for Neuro - Oncology, physician scientists from the University of New Mexico Comprehensive Cancer Center reported that a large number of study participants responded well to the drug combination.

Although these platforms can be used successfully for small - scale expansion of hMSCs, other platforms will be required to generate the quantity of cells required to support the increasing number of clinical trials utilizing hMSCs and the subsequent large - scale production.

Importantly this new vaccine has a better safety profile than traditional injection allergen immunotherapy, however the trial participants experienced a high frequency of local side effects which were unexpected and warrants further investigation in larger numbers of patients.»

take a lead in developing the next generation of cancer cell lines and use cell lines to systematically explore in vitro sensitivity to large numbers of anticancer drugs and drug combinations in order to inform choice of cancer types for early drug trials.

In the first trial (Neurology 2007; 68:51 — 55), 12 weeks of phenylbutyrate treatment produced no beneficial effects, although the small number and relatively large age range of the patients may have hidden a modest effect.

There have been a number of challenges with these new drugs, and they haven't really made it to phase three clinical trials, and so the reason is that it's very difficult to develop very specific inhibitors, because there is a large family of these phosphatases and it's difficult to ensure a specificity of your drug.

«We have a larger number of patients in our group than on any single clinical trial, so we hope this will be an opportunity for researchers to learn about us and a way for us to learn more about our condition.

In a substudy, review outcomes were also compared across different types of clinical research, based in large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified human tissue.

This year we can expect to see large numbers of CRISPR gene - editing trials, but some are still afraid of this amazing technology.

While there have been a number of human clinical studies, we need larger, randomized, properly - controlled clinical trials that look specifically at these suspects.

However, large clinical trials with limited numbers of antioxidants, by that I mean few antioxidants out of all available ones, suggested that supplementing with a few antioxidants in large numbers may actually be harmful.

A large number of peer - reviewed research, including long - term randomized controlled trial data, has demonstrated that growth hormone replacement improves energy, strength, cardiac function, blood pressure, cholesterol levels, insulin sensitivity cognitive function, immunity, and psychologic well - being; decreases body fat; increases lean muscle; prevents and reverses heart disease; prevents and improves osteoporosis; and improves quality of life.

Before the new findings may find their way into treatment, they need to be backed up in a clinical trial with larger numbers of patients and MRI as the endpoint.

In evaluating the adaptogenic properties of Siberian ginseng, a large study reviewed the results of a number of clinical trials involving 2,100 healthy men and women ages 19 to 72.

365 D IETARY, FUNCTIONAL, AND TOTAL FIBER Energy Intake Grams of Dietary Fiber / Dietary Fiber Intake (g / d)(kcal / d) 1,000 kcal 16.1 2,722 5.9 20.7 2,787 7.4 24.3 2,781 8.7 28.3 2,754 10.3 34.8 2,705 12.9 2,000 a 12.4 6.2 16.6 2,000 8.3 19.6 2,000 9.8 23.0 2,000 11.5 28.9 2,000 14.45 1,600 b 11.5 7.2 14.3 1,600 8.9 16.4 1,600 10.25 18.8 1,600 11.75 22.9 1,600 14.31 Intervention Trials There have been a large number of intervention trials to ascertain whether fiber supplementation can alter blood lipid concentrations and therefore alter the risk oTrials There have been a large number of intervention trials to ascertain whether fiber supplementation can alter blood lipid concentrations and therefore alter the risk otrials to ascertain whether fiber supplementation can alter blood lipid concentrations and therefore alter the risk of CHD.

However, the large number of American sugars and» 3 Days Free Trial», make it worth a try.

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