Sentences with phrase «large numbers of drug»

That makes it relatively simple to gauge the effectiveness of large numbers of drug candidates in treating a condition caused by a particular mutation.

We have the highest percentage of «Christians» in this nation with the largest prison population, the larger number of drug users and that is a nation divided over religion because of god fearing Christians who believe in this wondrous loving god that gives little girls cancer to test the faith of her parents as they watch her dying.

A large number of drugs used today originate from nature.

«We wanted to see whether very - large - scale screening across a diverse collection of cancer cell lines and a large number of drugs could yield new combinations for patients with cancer,» says Adam Friedman, MD, PhD, of the CBRC and the MGH Cancer Center, who led the study.

Research led by scientists at the University of Birmingham shows more precisely how G protein - coupled receptors, which are the key target of a large number of drugs, work.

«This is an unbiased approach to combining the maximum possible data and comparing a large number of drugs rather than one versus a select handful, so there's much more confidence in these findings,» says Dr. Parikh.

Not exact matches

Since then, the film argues, a variety of measures — from Jim Crow laws to President Richard Nixon's «war on drugs» and President Bill Clinton's «three - strikes - you're - out» legislation — have served to send increasingly large numbers of black men in prison, and several legal scholars and activists interviewed on camera suggest a profit motive at work, as well as racism.

Topics included: early reporting on inaccuracies in the articles of The New York Times's Judith Miller that built support for the invasion of Iraq; the media campaign to destroy UN chief Kofi Annan and undermine confidence in multilateral solutions; revelations by George Bush's biographer that as far back as 1999 then - presidential candidate Bush already spoke of wanting to invade Iraq; the real reason Bush was grounded during his National Guard days — as recounted by the widow of the pilot who replaced him; an article published throughout the world that highlighted the West's lack of resolve to seriously pursue the genocidal fugitive Bosnian Serb leader Radovan Karadzic, responsible for the largest number of European civilian deaths since World War II; several investigations of allegations by former members concerning the practices of Scientology; corruption in the leadership of the nation's largest police union; a well - connected humanitarian relief organization operating as a cover for unauthorized US covert intervention abroad; detailed evidence that a powerful congressional critic of Bill Clinton and Al Gore for financial irregularities and personal improprieties had his own track record of far more serious transgressions; a look at the practices and values of top Democratic operative and the clients they represent when out of power in Washington; the murky international interests that fueled both George W. Bush's and Hillary Clinton's presidential campaigns; the efficacy of various proposed solutions to the failed war on drugs; the poor - quality televised news program for teens (with lots of advertising) that has quietly seeped into many of America's public schools; an early exploration of deceptive practices by the credit card industry; a study of ecosystem destruction in Irian Jaya, one of the world's last substantial rain forests.

As Fusion notes, «the nootropics community is surprisingly large and involved,» with a number of online forums offering recipes and information on users» drugs of choice.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SDrug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the Sdrug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

In the last 10 years, a large number of twin and multiple births are attributed to fertility treatments including fertility drugs and in vitro fertilization.

Other factors that may lead to fetal distress during pregnancy and labor include an advanced maternal age, drug or alcohol use, diabetes and a large number of prior deliveries.

When Chicago citizens were asked about the parks during five community forums convened by the Mayor «s Drug and Gang Task Force, the largest number of negative comments by far were about the district «s failure to make its programs known to the public.

When City Councilman Daniel Dromm (D - Jackson Heights) criticized Mayor Michael Bloomberg's administration for the large number of marijuana possession arrests made on his watch and advocated for legalizing medical marijuana, he said he was not dismissing the drug's ill effects.

The nation's largest pharmacy benefit manager, Express Scripts, will soon limit the number and strength of opioid drugs prescribed to first - time users as part of a wide - ranging effort to curb an epidemic affecting millions of Americans.

Drug - delivery devices that flag nonsensical number entry could prevent a large fraction of hospital - based errors and perhaps deaths.

Very large numbers of eggs (28 - 33) were retrieved and they underwent many more rounds of treatment (up to 10) with fertility drugs than is common practice.

In the March 19, 2004, issue of Science — dedicated to drug discovery — Phil Szuromi, Valda Vinson, and Eliot Marshall wrote: «In recent years, the number of new drugs approved annually by the U.S. Food and Drug Administration has at best stayed steady, despite large increases in R&D investment.&radrug discovery — Phil Szuromi, Valda Vinson, and Eliot Marshall wrote: «In recent years, the number of new drugs approved annually by the U.S. Food and Drug Administration has at best stayed steady, despite large increases in R&D investment.&raDrug Administration has at best stayed steady, despite large increases in R&D investment.»

A statin drug commonly used to lower cholesterol is not effective in reducing the number and severity of flare ups from chronic obstructive pulmonary disease (COPD), according to the results of a large multicenter clinical trial designed and directed by Gerard J. Criner, MD, Director of Pulmonary and Critical Care Medicine at Temple University Hospital in Philadelphia, PA..

Tissue engineers have been unable to grow epidermis with the functional barrier needed for drug testing, and have been further limited in producing an in vitro (lab) model for large - scale drug screening by the number of cells that can be grown from a single skin biopsy sample.

«Additional studies are needed to assess the effects of those drugs, with larger numbers of treated and untreated patients as well as individuals who do not have Parkinson's.»

But most Africans with HIV claim never to use drugs, engage in prostitution, or have large numbers of sexual partners.

A large number of these companies are clustered in Toronto, Montreal, Vancouver, Ottawa, and Saskatoon and provide a significant number of drug discovery jobs in those areas.

The system can yield dose - response curves for candidate drugs, screen the phenotypes of large numbers of gene mutations, or execute complex custom protocols for completely new experiments.

But a new study finds that just a few resistant mutants can protect large numbers of normal bacteria that would have been thought to be susceptible to the drug therapy.

The nanopores can be filled with specific cytokines, oligonucleotides, large protein antigens, or any variety of drugs of interest to allow a vast number of possible combinations to treat a range of infections.

An innovative technique that quickly produces large numbers of structurally related compounds is changing the way drugs are discovered

Analyzing large numbers of cells, each with slight differences in their DNA, for their ability to carry out a behavior or survive a drug treatment can reveal the importance of particular genes, or sections of genes, in those abilities.

«Despite strong evidence against the use of codeine in children, the drug continues to be prescribed to large numbers of them each year,» said Sunitha Kaiser, MD, UCSF assistant clinical professor of pediatrics at UCSF Benioff Children's Hospital San Francisco and lead author.

While the incidence of highly drug - resistant tuberculosis in the United States is still negligible, the disease is gaining ground in countries where large numbers of people have immune systems weakened by HIV.

He notes that the strategy opens up the possibility of repurposing a large number of existing drugs for PKD therapy.

The number of surgical procedures and drugs prescribed to treat and prevent cardiovascular disease has risen substantially over the past two decades, and in 2012 - 13 the NHS spent just under # 7 billion in England alone on cardiovascular disease, the largest chunk of which was spent on hospital care.

The test called SkimuneTM, which is trademarked and has a patent pending, has been successfully tested by a number of large pharmaceutical companies on drugs in development and provides a reliable result within two weeks.

Robert Beall becomes CEO of the CFF and, grasping the limitations of gene therapy, invests $ 3.2 million in Aurora Biosciences Corp., where cell physiologist Paul Negulescu begins to look for a chemical cure using high - throughput methods to test large numbers of potential drugs.

Antibiotics also are responsible for the largest number of medication - related adverse events and the cause of about one in five visits to emergency departments for adverse drug reactions.

In recent years, the number of new drugs approved annually by the U.S. Food and Drug Administration has at best stayed steady, despite large increases in R&D investment.

«Rapid access to large quantities of neurons will be useful for testing a significant number of pharmacological drugs in order to identify those capable of preventing the death of motor neurons,» concludes Cécile Martinat.

St. Michael's was the only site outside of the United States involved in the Phase 2 clinical trial for the drug and had the largest number of patients enrolled in the Phase 3 trial.

In a presentation of early clinical trial data to the 20th Annual Scientific Meeting of the Society for Neuro - Oncology, physician scientists from the University of New Mexico Comprehensive Cancer Center reported that a large number of study participants responded well to the drug combination.

Older adults who died from cancer had the largest increase in the number of drugs.

take a lead in developing the next generation of cancer cell lines and use cell lines to systematically explore in vitro sensitivity to large numbers of anticancer drugs and drug combinations in order to inform choice of cancer types for early drug trials.

The application of Dr. Snyder's techniques has enhanced the development of new agents in the pharmaceutical industry by enabling rapid screening of large numbers of candidate drugs.

Using good quality data from a large number of people, the experienced scientists conducting this research found that people who took certain types of arthritis drugs had a lower risk of dementia than people not taking this treatment.

As potential lead drug candidates, we generated a large number of derivatives of the curry spice curcumin, which is effective in AD transgenic mice [8, 9].

In the search for compounds that might alter a protein's behavior or function — such as that of alpha - synuclein — drug companies often rely on so - called target - based screens that test the effect large numbers of compounds have on the protein in question in rapid, automated fashion.

Because this idea was so attractive to researchers studying brain diseases, a large number of potential drugs were developed by pharmaceutical companies that block glutamate receptors, including mGluR5.

Our plant technology allows us to provide a cost - effective production solution for drugs needed in large quantities due to the number of people affected by disease and / or high dosage requirements.

Normally, a phase 2 study is conducted in a slightly larger number of people, with the goal of collecting a little bit of evidence that the drug may work.

There have been a number of challenges with these new drugs, and they haven't really made it to phase three clinical trials, and so the reason is that it's very difficult to develop very specific inhibitors, because there is a large family of these phosphatases and it's difficult to ensure a specificity of your drug.

We are applying it to evaluate large number of potential drug targets in a faster and more systematic way than before and to select the best ones to work on.