Sentences with phrase «large phase»

However, our promising results warrant further investigation in larger phase 3 disability - driven trials.»

«We demonstrated that quality can be accomplished across the sites, but consider a different approach to the design,» she said, explaining that rather than treating negative symptom patients as one homogenous target, priority should be given to exploring the usefulness of novel mechanisms in separate negative symptom domains to better define the target population and maximize the chance of success before launching large phase III trials.

It just makes large Phase III trials in hospital - based programs near impossible.»

A test - of - concept trial is not designed to establish the efficacy of a particular candidate but rather to help researchers decide if a candidate is worth testing in larger Phase III trials.

The approximately 100,000 - square - foot center — the first and largest phase of the project — is to be on the grounds of Nassau Community College and will be built with a combination of public and private funding: about $ 10 million in county capital funding, $ 25 million in asset forfeiture monies and about $ 5 million in donations raised by the foundation.

The Christie has the largest phase 1 clinical trials unit in the world, and its cancer researchers also work closely with industry to take their drugs through trials.

The largest Phase 1 study in the history of oncology, the research was conducted at UCLA and 11 other sites in the U.S., Europe and Australia.

Together, the trials are part of the largest phase III program in moderate to severe plaque psoriasis completed to date, which involved more than 3,300 patients in more than 35 countries.

We're delighted that our results have led to a larger phase 3 clinical trial which is now ongoing.»

«This study has led to a large phase II study that has not yet been published» said Dr. Issa.

Kipnes is currently recruiting patients for a second safety trial as well as a larger Phase 2 trial of the drug's effectiveness.

«Because the study showed a statistically significant benefit among patients whose disease progressed on an aromatase inhibitor, a larger phase III study comparing this combination to other approved therapies used after initial therapies fail, like exemestane and everolimus, should be done.»

It is the first and largest phase III randomized controlled trial of stable, synthetic human angiotensin II.

When Theravance, the company in South San Francisco, California, that developed the drug, designed the large phase III clinical trials needed for approval, the FDA simply required a demonstration that the drug eliminated symptoms of infection as reliably as the approved antibiotic vancomycin.

«In fact, these results informed the recent decision by officials at Brazil's Butantan Institute to advance the TV003 vaccine into a large phase 3 efficacy trial.»

«Given safety and positive trends toward effectiveness in this phase 2 study, a larger phase 3 study is warranted to test whether resveratrol is effective for individuals with Alzheimer's — or at risk for Alzheimer's,» Turner says.

The results of a large phase III study in seven African countries, which used a vaccine based on a protein snippet from Plasmodium falciparum, the malaria parasite, will be released before the end of the year.

Based on the results of this trial and past work, Ory said a larger phase three clinical trial — that is both randomized and controlled — is already underway investigating cyclodextrin for patients with NPC.

The drug has already demonstrated safety in nonhuman primate trials, and the cardiovascular research might even be able to skip ahead to a larger phase II trial based on safety data from the ongoing phase I studies, Leeper suggests.

They estimate that using these algorithms to predict outcomes could allow a drug sponsor to reduce the size of the trial by at least 20 % and save as much as $ 6 million in a large phase III trial.

Although just published in The Lancet, those findings have since been overtaken by strikingly positive results from the larger phase III trials.

Should the results of this study be repeated in the larger Phase III trial, it would lead to a new standard of care for kidney cancer patients, said Dr. Hammers, formerly of Johns Hopkins medical system, who holds the Eugene P. Frenkel, M.D. Scholar in Clinical Medicine at UT Southwestern.

We are now beginning a larger Phase 2 trial to better evaluate its effectiveness and confirm its safety.»

Dr. Henry noted that while ATHENA observed a small patient population, the results are promising and consistent with what was seen with PRECISE and should provide the foundation for a large phase 3 trial.

Long - term follow - up of a large phase III study showed that chemohormonal therapy involving docetaxel added to androgen deprivation therapy (ADT) prolongs overall survival (OS) over ADT alone in metastatic hormone - sensitive prostate cancer (mHSPC) patients with high - volume disease.

The researchers noted that initial clinical trial data have been validated in larger phase II trials in the setting of relapsed / refractory HL, non-Hodgkin's lymphoma (NHL), and multiple myeloma (MM).

A large phase I trial offers further evidence that the anti — PD - L1 agent avelumab is generally well tolerated and results in relatively few serious adverse events.

The trial mainly tested the safety of the drug in people, and so the final word on whether aducanumab works to ameliorate the memory and cognitive losses associated with Alzheimer's will have to wait until the completion of two larger phase III trials.

Plans are underway at the MHRP site in Nigeria to participate in a large phase 2 study of the ChAd3 Ebola vaccine.

Dr. Ribas is the principal investigator for a large phase 1 trial of the anti-PD-1 drug pembrolizumab, owned by Merck.

Merck's anti-PD-1 drug pembrolizumab (MK - 3475) is currently being investigated in a large a phase I trial for patients with metastatic melanoma and lung cancer.

Plans are being developed for a larger phase 2 trial to launch in the future at City of Hope.

One clinical trial has begun and others will follow that are large phase III, randomized clinical trials comparing salvage chemotherapy plus autologous stem cell transplant versus CAR T - cell therapy, that is, second - line therapy administered earlier in the disease course.

On May 23, just nine days after the Ryan Lee opening, Ross will unveil the first and largest phase of his ambitious summer show at MASS MoCA, «Clifford Ross: Landscape Seen & Imagined,» an immersive multi-media exhibition that takes place across two buildings, six galleries, two courtyards and two beer gardens.

The decision in Harrison v Coventry, if followed, also concerns me in that the amount of time expended in recording a triple level of coding contemporaneously in any case could be «disproportionate» to the amount of that time that is simply wasted in circumstances where cases or large phases are simply dealt with within the budget allowed by the court.

Anglo American on the formation of the Lafarge / Tarmac JV the largest Phase II investigation ever undertaken by the former UK Competition Commission