The alternative model is that mutations of
large phenotypic effect underlie most of these traits in dogs and that the same variants have been transferred to a wide diversity of dog breeds leading to phenotypic diversity from a narrow genetic base [5], [8], [12].
Not exact matches
We are particularly interested in assessing whether the majority of
phenotypic variation among breed - affiliated dogs is a consequence of QTLs of
large effect or whether much of the variation is attributable to many QTLs of modest or small
effect.
The
largest numbers of variants identified by genome - wide association are copy - number changes, which have a greater
phenotypic effect than do single nucleotide polymorphisms.