Sentences with phrase «large potential benefits»

Affecting an entire life course of a person has such large potential benefits that even costly interventions can make sense.

This study implies the larger potential benefits of the school garden programs.

Unarguably, the single largest potential benefit that can be perceived of as a result of belonging to a trade organization is the ability of such an organization to be able to stand up and articulate the benefits of its industry, particularly in the face of external challenges.

Not exact matches

With the benefit of hindsight, Novolker points out that for a business - to - business firm like his, many larger potential customers in the States may balk at the prospect of being the first customer, even if the supplier has a solid reputation in Canada.

«E-commerce creates the potential for even the smallest local firm to sell globally and, in so doing, creates an environment in which the benefits of trade can be shared by all Canadian firms, and not accrue to just large multinational firms,» the report says.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

This type of automatic payment is also good for borrowers because, among other things, it has the potential to help a small business eliminate cash flow lumpiness by making more frequent and smaller debits on a daily or weekly basis as opposed to requiring a large loan payment on a monthly basis — although that is not the only benefit to small business owners.

The paper is regarded as the first stage in a larger research project and aims to provide the fintech industry in Hong Kong with a reasonably comprehensive study of the key features, benefits, risks and potential of DLT.

Workers just beginning their careers, workers in professions with a high upside income potential, and individuals expecting a large windfall, such as a family trust or inheritance, can greatly benefit from contributing after - tax dollars to a Roth IRA or Roth 401 (k).

However, given that more complex products like loans and mortgages will likely require in - person service, you shouldn't dismiss the potential benefit of having a nearby Bank of America branch if you plan to buy a home or finance some other large purchase in the future.

Furthermore, it can be argued that confronting particular belief or non-belief claims with the potential of shaping individual behaviors (and at the larger scale, government policy, regulations, and laws) can, in fact, provide benefits.

However, when you consider the potential for your rewards points to skyrocket, not to mention the convenience Plastiq offers, this is a relatively small fee for what can be an extremely large benefit.

You replace the older Gen with a younger Gen, Cazorla will be replaced eventually and the club as a business would benefit more from a large fee so the budget for the potential replacement can be bigger.

This is an incredibly difficult question to answer for a variety of reasons, most importantly because over the years our once vaunted «beautiful» style of play has become a shadow of it's former self, only to be replaced by a less than stellar «plug and play» mentality where players play out of position and adjustments / substitutions are rarely forthcoming before the 75th minute... if you look at our current players, very few would make sense in the traditional Wengerian system... at present, we don't have the personnel to move the ball quickly from deep - lying position, efficient one touch midfielders that can make the necessary through balls or the disciplined and pacey forwards to stretch defences into wide positions, without the aid of the backs coming up into the final 3rd, so that we can attack the defensive lanes in the same clinical fashion we did years ago... on this current squad, we have only 1 central defender on staf, Mustafi, who seems to have any prowess in the offensive zone or who can even pass two zones through so that we can advance play quickly out of our own end (I have seen some inklings that suggest Holding might have some offensive qualities but too early to tell)... unfortunately Mustafi has a tendency to get himself in trouble when he gets overly aggressive on the ball... from our backs out wide, we've seen pace from the likes of Bellerin and Gibbs and the spirited albeit offensively stunted play of Monreal, but none of these players possess the skill - set required in the offensive zone for the new Wenger scheme which requires deft touches, timely runs to the baseline and consistent crossing, especially when Giroud was playing and his ratio of scored goals per clear chances was relatively low (better last year though)... obviously I like Bellerin's future prospects, as you can't teach pace, but I do worry that he regressed last season, which was obvious to Wenger because there was no way he would have used Ox as the right side wing - back so often knowing that Barcelona could come calling in the off - season, if he thought otherwise... as for our midfielders, not a single one, minus the more confident Xhaka I watched played for the Swiss national team a couple years ago, who truly makes sense under the traditional Wenger model... Ramsey holds onto the ball too long, gives the ball away cheaply far too often and abandons his defensive responsibilities on a regular basis (doesn't score enough recently to justify): that being said, I've always thought he does possess a little something special, unfortunately he thinks so too... Xhaka is a little too slow to ever boss the midfield and he tends to telegraph his one true strength, his long ball play: although I must admit he did get a bit better during some points in the latter part of last season... it always made me wonder why whenever he played with Coq Wenger always seemed to play Francis in a more advanced role on the pitch... as for Coq, he is way too reckless at the wrong times and has exhibited little offensive prowess yet finds himself in and around the box far too often... let's face it Wenger was ready to throw him in the trash heap when injuries forced him to use Francis and then he had the nerve to act like this was all part of a bigger Wenger constructed plan... he like Ramsey, Xhaka and Elneny don't offer the skills necessary to satisfy the quick transitory nature of our old offensive scheme or the stout defensive mindset needed to protect the defensive zone so that our offensive players can remain aggressive in the final third... on the front end, we have Ozil, a player of immense skill but stunted by his physical demeanor that tends to offend, the fact that he's been played out of position far too many times since arriving and that the players in front of him, minus Sanchez, make little to no sense considering what he has to offer (especially Giroud); just think about the quick counter-attack offence in Real or the space and protection he receives in the German National team's midfield, where teams couldn't afford to focus too heavily on one individual... this player was a passing «specialist» long before he arrived in North London, so only an arrogant or ignorant individual would try to reinvent the wheel and / or not surround such a talent with the necessary components... in regards to Ox, Walcott and Welbeck, although they all possess serious talents I see them in large part as headless chickens who are on the injury table too much, lack the necessary first - touch and / or lack the finishing flair to warrant their inclusion in a regular starting eleven; I would say that, of the 3, Ox showed the most upside once we went to a back 3, but even he became a bit too consumed by his pending contract talks before the season ended and that concerned me a bit... if I had to choose one of those 3 players to stay on it would be Ox due to his potential as a plausible alternative to Bellerin in that wing - back position should we continue to use that formation... in Sanchez, we get one of the most committed skill players we've seen on this squad for some years but that could all change soon, if it hasn't already of course... strangely enough, even he doesn't make sense given the constructs of the original Wenger offensive model because he holds onto the ball too long and he will give the ball up a little too often in the offensive zone... a fact that is largely forgotten due to his infectious energy and the fact that the numbers he has achieved seem to justify the means... finally, and in many ways most crucially, Giroud, there is nothing about this team or the offensive system that Wenger has traditionally employed that would even suggest such a player would make sense as a starter... too slow, too inefficient and way too easily dispossessed... once again, I think he has some special skills and, at times, has showed some world - class qualities but he's lack of mobility is an albatross around the necks of our offence... so when you ask who would be our best starting 11, I don't have a clue because of the 5 or 6 players that truly deserve a place in this side, 1 just arrived, 3 aren't under contract beyond 2018 and the other was just sold to Juve... man, this is theraputic because following this team is like an addiction to heroin without the benefits

Two congressional Democrats are demanding more information about President Trump's potential conflicts of interest stemming from his part ownership of the nation's largest federally subsidized housing complex, Starrett City, which they say could benefit financially from decisions made by HUD.

«For immigrant communities, communities of color, and New Yorkers at large, a convention carries far more risks than potential benefits.

The biggest potential business tax cut benefiting a large chunk of wealthy New Yorkers — a reduction in tax rates for owners of pass - through entities — is the least likely of the proposed Trump reforms to be enacted any time soon.

Holt noted that AAAS, the world's largest general scientific society, has defended and advanced the scientific process and communicated its potential for generating benefits for humanity amid «countless shifting political winds» since its founding in 1848, and will continue to do so.

«Randomized trials have confirmed the value of radiation dose escalation for prostate tumors, and the potential benefits of larger radiation doses in fewer fractions, are expected to increase the therapeutic efficacy for men with prostate cancer,» said Anders Widmark, MD, a professor of radiation sciences at Umeå University in Umeå, Sweden and lead author of the study.

And scientists who conduct human challenge studies, which typically involve a few dozen participants, say they have critical benefits: In addition to saving time and money, they can reveal harm caused by a potential drug or vaccine before it enters large - scale human efficacy trials.

«Key benefits of large - scale use of universal over conventional flu vaccines: Mathematical model reveals potential effects of new vaccines that target multiple flu strains.»

To test the potential benefit and safety of targeted hypothermia in donors on delayed organ function rates in the recipients of their kidneys, Niemann and his research team conducted a randomized controlled trial in two large organ donation service areas from March 2012 to October 2013.

The study was the first randomized - controlled trial to examine the potential benefits of the low fat diet on the management of MS.. The study found no significant differences between the two groups in brain lesions detected on MRI brain scans or on other measures of MS.. But while the number of trial participants was relatively small, study leaders believe the significantly improved fatigue symptoms merited further and larger studies of the diet.

The technique has the potential to benefit a large population of patients with neurodegenerative disorders, where there remains a specific unmet need for blood - brain penetrating therapeutic delivery strategies.

Terry Engelder, a geologist at Pennsylvania State University, University Park, who was among the first to recognize the economic potential of the Marcellus Shale formation, says that large data sets like the one Siegel is working with is, at least, one benefit of the whole fracking controversy.

The potential benefits may be revealed by future research on behavior — such as remembering tasks throughout the day and driving safely — in larger groups of adults.

Dr Andreoli concluded: «The potential of using CO2 for making everyday materials is huge, and would certainly benefit large - scale producers.

«These are encouraging results, and we hope to verify the potential benefits of COX - 2 inhibitors soon in a large clinical trial,» said senior author Scott Hultgren, PhD, the Helen L. Stoever Professor of Molecular Microbiology.

«There are many potential benefits to concentrating our environmental impact by intensifying drivers of land - use change, such as agriculture and forestry, in exchange for gazetting large remote undisturbed reserves.

The article points to skepticism that, although home equity represents a large amount of total wealth among the middle - class, potential benefits to low - and moderate - income homeowners are questionable due to challenging mortgage terms and lower home value and appreciation rate.

Potential considerations include balancing health - related benefits and harms between individuals and the larger community, minimizing threats to individual privacy and autonomy, and ensuring just distribution of scarce resources.

This project aims to heighten awareness among relevant countries of the ecological role of large carnivores, their socio - economic impacts and the potential benefits of their presence.

Potential cardioprotection was based on generally supportive data on lipid levels in intermediate outcome clinical trials, trials in nonhuman primates, and a large body of observational studies suggesting a 40 % to 50 % reduction in risk among users of either estrogen alone or, less frequently, combined estrogen and progestin.2 - 5 Hip fracture was designated as a secondary outcome, supported by observational data as well as clinical trials showing benefit for bone mineral density.6, 7 Invasive breast cancer was designated as a primary adverse outcome based on observational data.3, 8 Additional clinical outcomes chosen as secondary outcomes that may plausibly be affected by hormone therapy include other cardiovascular diseases; endometrial, colorectal, and other cancers; and other fractures.3, 6,9

This large study with long - term follow - up was one of the first to examine the potential benefits of different doses and durations of aspirin use.

MONDAY, October 11 (Health.com)-- Folic acid supplements have long been thought to have potential heart benefits, but a large new study suggests that they don't lower the risk of heart attacks or strokes.

Folic acid supplements have long been thought to have potential heart benefits, but a large new study suggests that they don't lower the risk of heart attacks or strokes.

To make these recommendations, the Task Force looks at research — ideally, large - scale clinical trials — and weighs a procedure's potential costs versus benefits.

Large, longer term studies in populations who could benefit most from the potential benefits of outdoor exercise are necessary to completely analyze the effects of outdoor exercise on physical and mental wellbeing.

But, research studies haven't shown any benefit from taking these supplements, and some potential for harm if taken in very large doses.

Convinced of the transformative power of such a course, he envisioned the potential spreading of yoga and inner peace within the correctional facility in a sustainable way: Yoga teachers within would reach a larger inmate population and in turn benefit to the entire prison.

SAN FRANCISCO, April 3, 2017 — The first - ever global symposium, solely dedicated to sharing the latest scientific discoveries on the potential health benefits of 100 % pure maple products from Canada, took place on April 2 in San Francisco at the 253rd annual meeting of the American Chemical Society (ACS), the largest scientific society in the world.

One large Japanese study on the health benefits of green tea showed that a squeeze of lemon in the tea helped the body to absorb 13 % more of the tea's antioxidant potential than tea consumed without the lemon!

You'll benefit from practicing this pose toward the end of the sequence, because the previous poses will soften the larger back muscles that would otherwise prevent each vertebra from twisting to its full potential.

We're eating «twice as much protein» as we need, so the first thing we can recommend is just «decreasing the intake of protein... has... a large potential to bring health benefits.»

The benefit of a Christian dating site is the large number of Christians in every age group gives you a much larger pool of potential Christian dating partners to choose from.

A much larger pool of potential mates is one of the biggest benefits of online dating services.

plusizedating.com enables its members many benefits including a large membership database to chose from, the ability to not only post photos to profiles, but, to rate them, generate a friends list, send instant flirts and email messages, save potential matches, post a blog and create alerts of new joining matching members.

Senior dating sites bring the benefit of a large list of potential partners in your area.

Online services for those Catholic dating sites bring the benefit of a large list of potential partners, as opposed to the small number of people you might find on your own.

However, with the potential benefits of making the switch, including large savings on IT investments, easier access and greater levels of security, it could be the best decision that your school makes around technology.