Sentences with phrase «large randomized studies»

There have already been other large randomized studies which haven't shown a significant connection between inhaled corticosteroids and diabetes onset.

In 2010, ANet won a competitive $ 5 million Investing in Innovation (i3) grant from the U.S. Department of Education, which it is using, in part, to fund a large randomized study of its impact.

Not exact matches

«A Large, Randomized, Prospective Study of the Impact of a Pre-Run Stretch on the Risk of Injury in Teenage and Older Runners» http://www.usatf.org/stretchStudy/index.asp (accessed September 7, 2010)

The most recent findings of the Belarus study (an excellent, large scale, randomized, first world study) were recently published and show that 11 year - olds have a 17 % GREATER chance of being obese or overweight if they were in the breastfeeding group than in the control group.

Static stretching neither prevented or induced injury when compared to not stretching before running, according to the results of a first - of - its - kind large scale randomized study presented at the 2011 Annual Meeting of the American Academy of Orthopaedic Surgeons in San Diego.

He points to research by a Stanford University researcher, Allan K. Mishra, who has studied PRP for years, whose in his most recent published research includes a large multicenter study [8] involving a host of well - respected orthopedic surgeons around the country who followed 230 patients in a double - blind randomized control study [the gold standard for medical research].

This study is still the largest randomized control trial done to date on HFA.

The results of our study are also consistent with a large cluster randomized trial25 of breastfeeding promotion in which verbal IQ at age 6.5 years was 7.5 points (one - half of an SD) higher in the breastfeeding promotion group.

In addition, there was no effect on breastfeeding duration when the pacifier was introduced at 1 month of age.280 A more recent systematic review found that the highest level of evidence (ie, from clinical trials) does not support an adverse relationship between pacifier use and breastfeeding duration or exclusivity.281 The association between shortened duration of breastfeeding and pacifier use in observational studies likely reflects a number of complex factors such as breastfeeding difficulties or intent to wean.281 A large multicenter, randomized controlled trial of 1021 mothers who were highly motivated to breastfeed were assigned to 2 groups: mothers advised to offer a pacifier after 15 days and mothers advised not to offer a pacifier.

«This is the largest randomized trial of any behavioral intervention in children with autism spectrum disorder, and it shows that parent training works,» notes Lawrence Scahill, MSN, PhD, professor of pediatrics at Marcus and Emory School of Medicine, who directed the study.

More large - scale, randomized controlled studies are needed to tease out the risks and benefits.

The researchers write that a large - scale, controlled and randomized study should be conducted to validate their findings.

«Randomized trials have confirmed the value of radiation dose escalation for prostate tumors, and the potential benefits of larger radiation doses in fewer fractions, are expected to increase the therapeutic efficacy for men with prostate cancer,» said Anders Widmark, MD, a professor of radiation sciences at Umeå University in Umeå, Sweden and lead author of the study.

To identify the relevant mutations the scientists analyzed the blood samples of 1,858 men from three independent cohorts in Europe and North America: the Swiss arm of the European Randomized Study for Prostate Cancer Screening, the large American Screening trial, Prostate, Lung, Colorectal, and Ovarian (PLCO), Princess Margaret Cancer Centre (University Health Network) and Mount Sinai Hospital (Sinai Health System) in Toronto.

«It is still possible, however, that vitamin D supplementation could have beneficial effects on cardiovascular health via non-blood pressure effects, and ongoing large randomized trials are due to report on this in the next few years,» the study concludes.

Using simple statistics, without data about published research, Ioannidis argued that the results of large, randomized clinical trials — the gold standard of human research — were likely to be wrong 15 percent of the time and smaller, less rigorous studies are likely to fare even worse.

The study is believed to be the first and largest, multicenter, double - blind, randomized controlled trial of its kind to investigate the use of sublingual immunotherapy against ragweed allergy.

Larger, well - designed studies, such as cluster randomized trials, are ultimately needed to confirm the effectiveness of this strategy,» writes Alice Y. Guh, M.D., M.P.H., and L. Clifford McDonald, M.D., of the Centers for Disease Control and Prevention, Atlanta.

Contrary to the proclamations of many scientists, unreliable medical study results do not disappear with large, randomized controlled trials, in which subjects are randomly assigned to a treatment or placebo group.

«We are currently waiting for the results of a larger, randomized study currently being conducted in the United Kingdom that uses the same Risk of Ovarian Cancer Algorithm in a similar population of women.

The study was the first randomized - controlled trial to examine the potential benefits of the low fat diet on the management of MS.. The study found no significant differences between the two groups in brain lesions detected on MRI brain scans or on other measures of MS.. But while the number of trial participants was relatively small, study leaders believe the significantly improved fatigue symptoms merited further and larger studies of the diet.

Called the high - dimensional propensity score algorithm (hd - PS), it is a tool for improving not randomized clinical trials but broader observational studies, in which researchers watch a large pool of participants and look for correlations — like the fact that wine drinkers live longer than other drinkers.

The Physicians» Health Study II (PHS II) remains the only randomized, large - scale, long - term trial to test whether a daily multivitamin reduced cardiovascular disease risk, and researchers found that after 11 years of follow up, there was no significant difference in risk of major cardiovascular disease (CVD) events among men who took a multivitamin compared to those that took a placebo.

Based on the study published, a larger randomized trial is underway in Tanzania to determine if DAR - 901 prevents the earliest stage of infection with tuberculosis, before symptoms are apparent.

The 10 - year Warfarin and Aspirin for Reduced Cardiac Ejection Fraction (WARCEF) trial is the largest randomized, double - blind comparison of aspirin and warfarin (also known by its brand name Coumadin) for heart failure, following 2,305 heart failure patients whose heart muscle pumps less oxygen - rich blood into the body, known as reduced ejection fraction, at 168 study sites in 11 countries on three continents.

«The results in our study are very similar to those obtained in a large European randomized clinical study (ERSPC) thus confirming the effect of PSA testing on the risk of prostate cancer death.

A 2000 study by Hannah et al. was the largest, randomized controlled trial to examine the type of deliver on mother and infant outcomes.

The early findings are so promising that the researchers have been awarded a grant from the Australian Research Council, in partnership with Villa Maria Catholic Homes, to follow up on the study with a large randomized control trial.

Ideally, Hirsch and Morello said they would like to conduct a larger, randomized study with multiple clinics and multiple health systems over a longer time period.

«PROBIT, the largest randomized trial ever carried out in the area of human lactation, continues to yield scientifically and clinically important information more than two decades after its inception,» says Dr. Michael Kramer, from McGill's Faculty of Medicine and the Research Institute of the McGill University Health Centre (RI - MUHC), the Principal Investigator on the PROBIT study.

In this study, to our knowledge the largest randomized clinical trial of robotic - assisted laparoscopic surgery for patients with rectal adenocarcinoma suitable for curative resection, there were no statistically significant differences in the rates of conversion to open laparotomy for robotic - assisted laparoscopic surgery compared with conventional laparoscopic surgery (8.1 % vs 12.2 %, respectively), and there were no statistically significant differences in CRM +, complication rates, or quality of life at 6 months.

A large - scale randomized clinical study is needed to confirm the therapeutic value of video - game treatment in clinical situations.

«While the results of this study are preliminary, they hold promise for enhancing and maintaining brain reserve in later life, particularly among sedentary individuals who may benefit most urgently from behavioral interventions like Experience Corps,» said Carlson, who is now leading a larger fMRI trial as part of a large - scale randomized trial of the Baltimore Experience Corps Program.

These findings are generally consistent with those from recent systematic reviews, some of which also included trials of statins for secondary prevention.47,51 - 53 Similar to other meta - analyses of primary and secondary prevention trials, 54,55 this review found no association between use of statins and increased risk of muscle - related harms, although some observational studies and randomized rechallenge trials found statins associated with increased risk of myopathy or joint - related symptoms.56 - 58 The large HOPE - 3 trial found statins associated with increased risk of cataract surgery, an unanticipated finding.14 No other trial of statins for primary prevention evaluated risk of cataracts or cataract surgery.

A Phase 3, Randomized, Open - Label Study Evaluating the Efficacy of Axicabtagene Ciloleucel versus Standard of Care Therapy in Subjects with Relapsed / Refractory Diffuse Large B Cell Lymphoma (ZUMA - 7)

We are currently performing process development of our AST - VAC1 manufacturing process in preparation for a confirmatory Phase 2b study designed to reproduce these results in a larger, randomized trial.

5/21/2007 Nationwide Study Compares Surgeries to Treat Urinary Incontinence in Women The University of California, San Diego Medical Center along with nine other clinical research institutions across the United States has completed the largest randomized clinical trial to date comparing two commonly performed surgical procedures to t...

The drug, a monoclonal antibody called ipilimumab, is the first treatment of any kind ever shown in a large, randomized phase III clinical study (study MDX010 - 20) to improve overall survival in patients with metastatic melanoma who no longer respond to standard therapy.

The LEAP study, designed and conducted by the ITN with additional support from FARE and led by Professor Gideon Lack at Kings College London, is the first randomized trial to prevent food allergy in a large cohort of high - risk infants.

A large, randomized study led by a UNC Lineberger Comprehensive Cancer Center researcher found that vitamin D and calcium supplements do not reduce the risk of colorectal adenomas, which are benign tumors that can evolve into colorectal cancer.

While there have been a number of human clinical studies, we need larger, randomized, properly - controlled clinical trials that look specifically at these suspects.

The final nail in the coffin was the 2006 Women's Health Initiative, the largest randomized dietary study ever undertaken, which proved this notion false.

Likewise, a large meta - analysis study of 10 randomized, double - blind studies found that on average, chromium led to a 1.1 kg loss in weight [6].

A 7 - month randomized control study showed milk supplemented with Lactobacillus rhamnosus SP1 resulted in reduced larger dental caries in children.

Further support for the benefit of plant - based diets comes from a large, randomized feeding study of blood pressure reduction, the 8 - wk DASH study in 459 people (46).

The Women's Health Study is the largest randomized clinical trial to investigate the impact of aspirin and vitamin E on the primary prevention of cardiovascular and cancer...

[2, 4] Eating two larger meals a day (breakfast and lunch) is more effective than six smaller meals in a reduced - energy regimen for patients with type 2 diabetes: a randomized crossover study.

There are 4 relatively large, randomized «diet - induced weight loss» studies that all reported fairly comprehensive food intake and body composition data.

Recent randomized controlled studies back up the point that diet drinks may sabotage weight loss efforts despite the large decrease in consumed sugars.

And when the rigorous evidence is available from randomized controlled trials, often the results are at odds with the findings of the observational studies,» explains Dr. JoAnn Manson, chief of preventive medicine at Brigham and Women's Hospital, professor of medicine at Harvard Medical School, and principal investigator of a large randomized trial known as VITAL (Vitamin D and Omega - 3 Trial).