Sentences with phrase «large research trials»

Two large research trials, in which men are randomized to undergo or not undergo PSA testing, are under way in the United States and in Europe.

Not exact matches

Following preliminary clinical trials, the company is now in discussion with a major New York City hospital to integrate Fever Smart into a large clinical research program.

Plenty of respected research supports the safety of planned home birth (most recent large prospective trial published in the British Medical Journal), but for women who need to deliver in a hospital due to a complication, the midwife stays by your side and adopts a doula role.

The protective effects of breast feeding have been shown to be dose responsive16 17 18 and minimal breast feeding may not be protective.17 Researchers in lactation have advocated that research on promotion of breast feeding must target exclusive breast feeding, 19 and ours is one of the larger randomised controlled trials with this primary outcome.

They may have done a thesis with a translational focus, but few will have received training in the requirements for doing modern patient - oriented research, which includes large doses of epidemiology, statistics, and human - subject trial design.

In light of the results, the CNIO Breast Cancer Clinical Research Unit has already launched a large - scale Phase II Clinical Trial to validate the results in a large group of patients.

The research team is planning larger, multicenter trials to confirm the role of subglandular ADC analysis in predicting preterm birth, Dr. Masselli said.

In science news around the world, the National Institutes of Health expands the definition of clinical trials, the U.S. Department of Agriculture restores previously public animal welfare records, seismologists fear the loss of a key research vessel, Brazil's indigenous tribes win land rights, and China's — and the world's — largest radio telescope gets a no - fly zone.

That's because a trial like this one is almost without precedent in modern medical research: It involves giving children a vaccine that is almost certain not to benefit them, and that might harm them, all to protect other children from an unlikely scenario — a large - scale anthrax attack.

People diagnosed with cancer gained 3.34 million years of life thanks to cancer clinical trials run by SWOG and supported with public funds, according to new study results to be presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO), the world's largest clinical cancer research meeting.

The downside is that, when a clinical trial works and promises large revenues, we have to stimulate our research very quickly.

«Our research is exciting as it represents the only double - blind, randomized clinical trial with this large of a sample size, and a mid-term follow - up rate of five years,» noted Mohtadi.

In one trial, the research team selectively removed the largest species of coral guard - crab, T. flavopunctata, from corals in the path of the army of sea stars and observed the effects.

To test the potential benefit and safety of targeted hypothermia in donors on delayed organ function rates in the recipients of their kidneys, Niemann and his research team conducted a randomized controlled trial in two large organ donation service areas from March 2012 to October 2013.

Using simple statistics, without data about published research, Ioannidis argued that the results of large, randomized clinical trials — the gold standard of human research — were likely to be wrong 15 percent of the time and smaller, less rigorous studies are likely to fare even worse.

The attendees developed a list of top research priorities and a research agenda for exercise in solid organ transplant, which includes the need to conduct large multicenter intervention studies, standardize measures of physical function in clinical trials, examine the benefits of novel types of exercise, and assess the effects of exercise on measures such as immunity, infection, and cognition.

Dr Chris Gale is supported by a Medical Research Council (MRC) Clinician Scientist Fellowship to develop large, simple clinical trials that use routinely recorded electronic health record data held in the National Neonatal Research Database (NNRD).

While some research suggests that a diet high in omega - 3 fatty acids can protect brain health, a large clinical trial by researchers at the National Institutes of Health found that omega - 3 supplements did not slow cognitive decline in older persons.

While a postdoctoral fellow at the Naval Medical Research Institute in Bethesda, he developed a system for large - scale efficient culture of lymphocytes that has proved to be the foundation for over 35 early phase clinical trials of adoptive immunotherapy.

The results come from analysis of one arm of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS), the world's largest ovarian cancer screening trial, led by UCL and funded by the Medical Research Council, Cancer Research UK, Department of Health and The Eve ApTrial of Ovarian Cancer Screening (UKCTOCS), the world's largest ovarian cancer screening trial, led by UCL and funded by the Medical Research Council, Cancer Research UK, Department of Health and The Eve Aptrial, led by UCL and funded by the Medical Research Council, Cancer Research UK, Department of Health and The Eve Appeal.

Despite lowering low - density lipoprotein (LDL), known as «bad» cholesterol, while markedly increasing levels of high - density lipoprotein (HDL), or «good» cholesterol, a large clinical trial to investigate the cholesterol drug evacetrapib was discontinued early after a preliminary analysis showed it did not reduce rates of major adverse cardiovascular events, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.

A large randomized controlled trial of ischemic postconditioning in patients who had experienced the deadliest form of heart attack — ST - segment elevation myocardial infarction (STEMI)-- failed to show that this procedure significantly reduces death from any cause or hospitalization for heart failure, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.

Our current research combined with information from large clinical trials with antioxidants suggests that people who have been recently diagnosed with cancer should avoid such supplements.»

Research fingering glutamate signaling in negative symptoms has spurred the idea of targeting glutamate receptors, but this approach has failed in large trials.

The drug has already demonstrated safety in nonhuman primate trials, and the cardiovascular research might even be able to skip ahead to a larger phase II trial based on safety data from the ongoing phase I studies, Leeper suggests.

«It's probably premature to run large trials without evidence that they have a therapeutic effect that [we] understand,» cautions Arnold Kriegstein, director of the Broad Center of Regenerative Medicine and Stem Cell Research at the University of California, San Francisco.

In 2002, the research team for TRIGR (Trial to Reduce IDDM in the Genetically at Risk), led in the U.S. by principal investigator Dorothy Becker, M.D., professor of pediatrics at Children's Hospital and the University of Pittsburgh School of Medicine, embarked on a large - scale study of 2,159 infants with a family member affected by type 1 diabetes and with genetic risk for type 1 diabetes to find out whether delaying the exposure to complex foreign proteins such as cow's milk proteins would decrease the risk of diabetes.

A large group of government researchers from the Centre for Ecology and Hydrology in Merlewood, Rothamsted Research, and the Scottish Crop Research Institute designed a trial that would pit three GM crops against conventional counterparts in some 60 fields across the country.

As the next step for this line of research, the investigators plan to expand to a larger prospective multicenter trial to further investigate the efficacy of the treatment in a larger sample of patients with dry AMD.

The early findings are so promising that the researchers have been awarded a grant from the Australian Research Council, in partnership with Villa Maria Catholic Homes, to follow up on the study with a large randomized control trial.

«PROBIT, the largest randomized trial ever carried out in the area of human lactation, continues to yield scientifically and clinically important information more than two decades after its inception,» says Dr. Michael Kramer, from McGill's Faculty of Medicine and the Research Institute of the McGill University Health Centre (RI - MUHC), the Principal Investigator on the PROBIT study.

The Lifespan Cancer Institute is Rhode Island's largest center dedicated to the diagnosis and treatment of all cancers and blood disorders; to cutting - edge research and clinical trials, and to the survival and follow - up care of all patients.

Another major pharma player, Roche, canceled its BACE1 research back in 2013, but several large - scale trials for BACE1 inhibitors are still currently in development or underway.

This will allow patients to be more quickly matched to potentially lifesaving clinical trials, even as it leads to larger and richer analyses of data for research purposes.

The latest data, the result of the largest long - term follow - up study of autism treatment yet undertaken, is from a randomised controlled trial by three UK research groups and published in The Lancet.

In this study, O'Connor and colleagues studied all cases of morphologic induction failure from the large, multicenter Medical Research Council UK ALL 2003 trial, to determine whether end of induction MRD should be used in defining induction failure.

In a substudy, review outcomes were also compared across different types of clinical research, based in large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified humanresearch, based in large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified humanResearch, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified humanResearch and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified humanresearch focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified humanresearch; and (7) use of deidentified human tissue.

5/21/2007 Nationwide Study Compares Surgeries to Treat Urinary Incontinence in Women The University of California, San Diego Medical Center along with nine other clinical research institutions across the United States has completed the largest randomized clinical trial to date comparing two commonly performed surgical procedures to t...

The clinic is a national clinical trial centre for new pharmaceutical therapies; imaging research, advanced genetics and immunology research; and is home to the world's largest MS registries (database) of over 7500 patients, many of whom have been followed for over 25 years.

«If the pilot trial is successful, we plan to pursue a larger trial to explore this strategy's potential as a straightforward and cost - effective way to improve the existing therapy for AML and MDS,» said Peter Jones, Ph.D., D.Sc., co-senior author of the PNAS study, chief scientific officer at Van Andel Research Institute (VARI) and co-leader of the Van Andel Research Institute — Stand Up To Cancer (VARI — SU2C) Epigenetics Dream Team.

To make these recommendations, the Task Force looks at research — ideally, large - scale clinical trials — and weighs a procedure's potential costs versus benefits.

In the new study, a research team led by David M. Nathan, MD, of Massachusetts General Hospital, in Boston, looked at results from three large, long - term studies: the Diabetes Control and Complications Trial (DCCT); its follow - up study, the Epidemiology of Diabetes Interventions and Complications (EDIC); and the Pittsburgh Epidemiology of Diabetes Complications (EDC) study.

A large number of peer - reviewed research, including long - term randomized controlled trial data, has demonstrated that growth hormone replacement improves energy, strength, cardiac function, blood pressure, cholesterol levels, insulin sensitivity cognitive function, immunity, and psychologic well - being; decreases body fat; increases lean muscle; prevents and reverses heart disease; prevents and improves osteoporosis; and improves quality of life.

Harry Wang, director of health and mobile product research at Parks Associates, a Dallas - based market research firm, said the study is one of the largest randomized trials of its kind and appears to be well - designed.

The research presented here is the first large - scale randomized - control trial designed to measure what students learn from school tours of an art museum.

In large part because randomized trials are considered the gold standard of research design and are used in medical research, many contend that the only way to truly professionalize education research is to demand the use of randomized trials or «true experiments.»

However, The independent evaluators from National Centre for Social Research found that the children who received the Switch - on intervention in this larger trial made no more progress than the children in the «business as usual» control group.

Beginning in 2015, a coalition of research and education institutions will launch a large - scale, randomized controlled trial evaluation of principal professional development funded by the U.S. Department of Education's Institute of Education Sciences.

The Center's staff has extensive experience in statistical analyses and data management, qualitative research methods, randomized controlled trials and quasi-experimental studies, and large - scale surveys.

By sharing the hospital's successes with the community at large, we help generate funding for state - of - the - art equipment, new research projects and clinical trials, and help attract new star recruits to work at The Ottawa Hospital.