In a separate paper published in the same issue of ChemBioChem, the researchers demonstrated that they could use this technology not only to synthesize peptides, but also combine these to form
large synthetic proteins.
Not exact matches
«Recent advances in chemical
protein synthesis make it more feasible to produce
larger synthetic D -
proteins,» says Michael S. Kay, M.D., Ph.D., professor of biochemistry at the University of Utah School of Medicine and senior author of the study.
«We wondered if we could make and fold
larger proteins to greatly expand the reach of mirror - image drug discovery,» adds Dr. Weinstock (now a scientist at
Synthetic Genomics, La Jolla, CA).
The valve consists of a channel
protein, the mechanosensitive channel of
large conductance (MscL) from Escherichia coli, modified by attachment of
synthetic compounds that undergo light - induced charge separation to reversibly open and close a 3 - nanometer pore.
Our data are also consistent with the contention that there is no
protein synthetic advantage gained by consuming increasingly
large servings of
protein in a single meal (7, 16).
Most are made with highly processed ingredients and often include artificial flavours,
synthetic sweeteners, cheap chocolate coatings, and soy
protein (the
largest genetically modified crop in the world).