Sentences with phrase «large systematic study»

In the first large systematic study of protein localization in the cell, 263 previously unlocalized proteins could be mapped to individual compartments in the cell and the existence of 65 proteins was shown for the very first time.

Not exact matches

Even so, in their conclusions, the authors of the paper are highly cautious, and say: «Despite the large significance of the measurement reported here and the stability of the analysis, the potentially great impact of the result motivates the continuation of our studies in order to investigate possible still unknown systematic effects that could explain the observed anomaly.

With absolutely no indication about the quality of the studies (and methods used) in each individual study, readers have no way of assessing the quality of the larger systematic review.

* And in the largest and possible most systematic study to date, conducted on five different ethnic groups from both Chicago and New York involving over 1,400 subjects Mosenkis (2000) found far more positive adult outcomes for individuals who coslept as a child, among almost all ethnic groups i.e. African Americans and Puerto Ricans in New York, Puerto Ricans, Dominicans, and Mexicans in Chicago than there were negative findings.

In addition, there was no effect on breastfeeding duration when the pacifier was introduced at 1 month of age.280 A more recent systematic review found that the highest level of evidence (ie, from clinical trials) does not support an adverse relationship between pacifier use and breastfeeding duration or exclusivity.281 The association between shortened duration of breastfeeding and pacifier use in observational studies likely reflects a number of complex factors such as breastfeeding difficulties or intent to wean.281 A large multicenter, randomized controlled trial of 1021 mothers who were highly motivated to breastfeed were assigned to 2 groups: mothers advised to offer a pacifier after 15 days and mothers advised not to offer a pacifier.

«This method has important implications for the way future systematic studies are conducted as it provides researchers with a way to strategically target regions of interest in their study organism, such as single - copy regions of the nuclear genome or portions of organellar genomes, to produce large data sets at low costs,» says Uribe - Convers.

Researchers expect the data presented in this study to fuel the formation of large national and international research consortiums to conduct comprehensive, systematic analysis of inherited (germline) genome data in large cohorts of uveal melanoma patients.

The study — a systematic review and meta - analysis of published data — is the largest to quantify whether e-cigarettes assist smokers in quitting cigarettes.

Before this study, there had been no large ‐ scale, systematic longitudinal analysis of suicide in Greece, and suicide data were lumped by year, not month, making it harder to test the short ‐ term relationship between specific events and deaths.

These findings are generally consistent with those from recent systematic reviews, some of which also included trials of statins for secondary prevention.47,51 - 53 Similar to other meta - analyses of primary and secondary prevention trials, 54,55 this review found no association between use of statins and increased risk of muscle - related harms, although some observational studies and randomized rechallenge trials found statins associated with increased risk of myopathy or joint - related symptoms.56 - 58 The large HOPE - 3 trial found statins associated with increased risk of cataract surgery, an unanticipated finding.14 No other trial of statins for primary prevention evaluated risk of cataracts or cataract surgery.

The three newly - discovered radio - emitting brown dwarfs were found as part of a systematic study of nearby brown dwarfs using the National Science Foundation's Very Large Array (VLA) radio telescope.

In the largest and most systematic of these studies, Cantero et al. (2003) found that oscillations in the 4 — 7 Hz frequency range could be recorded from both the hippocampus and neocortex.

The three newly - discovered radio - emitting brown dwarfs were found as part of a systematic study of nearby brown dwarfs using the National Science Foundation's Very Large Array radio telescope.

Ageing research and more generally the study of the functional basis of human diseases profit enormously from the large - scale approaches and resources in mouse functional genomics: systematic targeted mutation of the mouse genome, systemic phenotyping in mouse clinics, and the archiving and distribution of the mouse resources in public repositories.

From this large - scale study of protein expression and localization, systematic errors as well as similarities between the IF and FP methods could be found.

«This is the first time the two imaging methods IF and FP have been combined to study the location of a large number of proteins in the cell in an efficient and systematic way», says Emma Lundberg, principal investigator and Director of the Subcellular Protein Atlas.

This study additionally demonstrates that the systematic examination of panels of biological candidate genes in large, well - characterised populations can be an effective complement to positional cloning approaches.

Another systematic review limited to primary prevention trials also found no association with increased risk of diabetes (4 trials; RR, 1.05 [95 % CI, 0.84 to 1.32]-RRB-.48 However, individual trials were inconsistent, with 1 large trial (JUPITER) reporting an increased risk (3.0 % vs 2.4 %; RR, 1.25 [95 % CI, 1.05 to 1.49]-RRB-.29 The JUPITER study was the only primary prevention trial reporting diabetes risk that evaluated high - potency statin therapy.

It's important to remember that, as this is a systematic review study, it provides large - scale average values rather than specific diet strategies.

My colleagues and I have studied spending patterns in large districts such as New York City, Chicago and Cleveland, and consistently found systematic differences in resources across schools within these districts (Rubenstein, et al., 2007; Stiefel, Rubenstein and Berne, 1998).

Still, the study's large sample size and systematic, controlled approach will yield data that could fuel research on questions that go well beyond cancer, he said - such as whether goldens in some geographic regions or with certain traits, like size or coat color, are more or less likely to have particular conditions.