Sentences with phrase «larger cell population»

This finding comes as a surprise, considering that the average migration speed of the larger cell population does not change through multiple cycles.

Yet, our knowledge about the regulation of the genome is generally based on datasets derived from large cell populations that provide an ensemble average interpretation of the biological system and disregard existing cell - to - cell heterogeneity.

Single - cell RNA - sequencing (scRNA - seq) allows studying heterogeneity in gene expression in large cell populations.

Not exact matches

However, the MIT team adapted it to randomly turn on or off distinct gene sets across large populations of cells, allowing the researchers to identify genes that protect cells from a protein associated with Parkinson's disease.

«Flow cytometry identified a large population of apoptotic melanoma cells, and single - cell electrophoresis indicated that mensacarcin causes genetic instability, a hallmark of early apoptosis,» Loesgen said.

They demonstrated that non-obese diabetic (NOD) mice treated with a specific (AID / RAD51) pathway inhibitor had larger populations of certain B cells that were capable of suppressing diabetogenic T cell responses, and greatly reduced T1D development, compared with untreated controls.

The idea is that these cells may be present in the body, but their population isn't large enough to exert an anti-tumor effect.

In order to thoroughly investigate cures for a diverse population, cell lines from a large sampling of individuals are needed.

Tanyi and colleagues made each patient's vaccine by sifting through the patient's own peripheral blood mononuclear cells for suitable precursor cells, and then growing these, in the lab, into a large population of dendritic cells.

Most theorists assume that such a complex concept would have to be supported by large populations of cells, each of which corresponds to one component of the object (the bun, the bifocals, the leather miniskirt).

Although the new JNCI study did not analyze individual cell phone usage — preferring instead to take a broader look at the population at large — other research has examined subgroups of cell phone users to try to discern different trends among more frequent use.

They observed that after allergic sensitization, some mouse strains generated large populations of MMC9 cells while other strains did not.

For instance, researchers often use so - called «gene guns» to fire particles coated with strands of DNA known as plasmids at large populations of cells.

Using only the DNA from sloughed - off cells floating in the ocean, scientists have been able to determine the population size and genetic properties of one of the world's largest and most mysterious animals: the whale shark.

They showed that when these cells experience warmer temperatures and get more nutrients they can double or triple their cell division rates, allowing them to potentially bloom into a large population fairly quickly at sea.

Lee hopes the work will allow other researchers to investigate the effects of transfection on individual cells, not just large populations.

«Computer - based classification of cells based on large population of cell images opens up new perspectives.

In the cases, just this last couple of elections, where stem cell politics, for example, has been played out in the electoral process, stem cell research is [has] done better than the winning candidates for offices; and I think, apart from that, I think that we do have a serious problem in general education of the sciences and that accounts for the reluctance of a large segment of the population to accept the principles of evolution and think that there is still a debate about it, which there isn't — and that's a problem we need to solve, — but I still think there is an incredible constituency for science in this country.

However, they had to carefully time the shutdown so that the cell population would be large enough to produce a substantial amount of glucaric acid.

The research group plans to move forward with more - advanced technology and larger populations to investigate field cancerization in other lung cancer subtypes, such as small - cell lung cancer, in smokers and in lung cancers that develop in non-smokers.

Most theorists assume that such a complex concept must be supported by large populations of cells, each of which corresponds to one component of the object (the bun, the bifocals, the leather miniskirt).

Using molecular tools, he and his colleagues conducted a study, published in Science in 2012, which showed that a large population of fungal cells — called a mycobiome — lives in the gut and likely plays a role in IBD.

AIM2 is present in all immune and epithelial cells, which make up a large part of the intestine's cell population and help to maintain a healthy gut.

Developing therapeutic cell populations from human ES cells will be far more demanding: cells will have to be stable, predictable, pure, have proven functionality, be nontumor - forming, and be «scalable» — capable of growing in very large numbers.

«What's particularly noteworthy about this work is we were able to present an integrative link from genetics, cell - and animal - based experiments, all the way up to clinical outcomes in large human population,» Liu said.

Today, analyzing and editing genomes, proteomes and metabolomes has become a standard for many model systems; imaging beyond the diffraction limit of light and new technologies for studying protein structures provide insights deeper than ever before; the characterization of large populations of cells or organisms brings unprecedented statistical power; and studying nearly all organisms of an ecosystems as a whole allows generating comprehensive models.

Proteomics — the large - scale study of proteins, particularly their structure and function — combined with transcriptomics — the examination of the expression level of messenger ribonucleic acids (mRNAs) in a given cell population - played a significant role in the recent derivation of a combined protein and gene list that constitutes one of the largest descriptive data sets of its kind.

This may be relevant for understanding the evolution of the large human CMV - specific CD8 + T cell populations seen in humans.

Clinical trials are now underway that aim to see if the large populations of T regulatory cells generated in the thymus can be exploited to better protect against type 1 diabetes.

However, with few exceptions, the stem cell and regenerative medicine industry has remained inadequately capitalized to carry out large - scale clinical trials independently, and major pharmaceutical firms have tended to show more interest in the use of hiPSCs as a source of large, pure populations of specific somatic cells for use in drug compound screening and toxicology tests, than they have in therapeutic uses of stem cells and their derivatives.

This is particularly true in the case of persistent herpesviruses such as human CMV, which are typified by large virus - specific CD8 + T cell populations during viral latency.

However, ostensibly homogeneous cell populations exhibit large clonal variance that can confound analyses and undermine reproducibility.

A robust CD45 + cell population was detected (A) of which a large portion was Gr - 1 + (B).

At 13 weeks, two distinct CD68 - positive cell populations were observed, one type was small and non-pigmented (Fig. 8C) and the other consisted of large highly pigmented cells (Fig. 8 D).

In the HIGH and MID populations, we observed more large (containing > 200 cell) colonies that were predominantly GCTM - 2 positive (Figure 4b — c).

The low density culture protocol helps in generating larger number of CD133 + endothelial population from initially fewer CD133 + endothelial progenitor cells; EPCs (Figure S1).

The Penn team was surprised by the large portion of the genome that changed its chromatin signature in senescence, particularly in the tightly bound laminar regions in the senescent cell population.

Unlike normal plasma cells, the malignant plasma cells look large and round with a high mitotic index (measure of the proliferation of a cell population) in early stages of cellular differentiation.

Pets are exposed to many of the same environmental risks as people The cancer cells are biologically comparable There is a large population of cats and dogs with pre-existing cases of cancer Cancer occurs in pets within years compared to decades in humans