The size of the brain's ventricles — cerebrospinal fluid - filled spaces deep within the brain — became progressively
larger during the course of treatment, and changes were also seen within the subventricular zone, one of two structures in which new brain cells are generated in adults.
Evidence from
large RCTs reveals that depressive symptoms and functional impairments may not improve at the same rate with
treatment.28, 70 Therefore, symptoms and functioning should be tracked regularly
during the
course of treatment with information gathered from both the patients and their families when possible.