Sentences with phrase «larger fibrils»

She says that these findings also have implications for designing treatments for Parkinson's, noting that some drugs currently under development are focused on getting rid of larger fibrils that make up Lewy bodies.

For the new study, Dokholyan's team, including lead author Cheng Zhu, PhD, a postdoctoral researcher in his lab, conducted complicated experiments to compare how trimers affect neurons to how larger fibrils affect neurons.

«But we were able to find an SOD1 mutation that stabilizes the trimer structure and another mutation that promotes the creation of the larger fibrils at the expense of smaller structures.

Not exact matches

But in a study published in the Proceedings of the National Academy of Sciences, scientists at the University of North Carolina at Chapel Hill found evidence that these large SOD1 fibrils protect rather than harm neurons.

«Large aggregates of ALS - causing protein might actually help brain cells: UNC School of Medicine scientists add to evidence that small aggregates of SOD1 protein are the brain - cell killing culprits in ALS, but the formation of larger, more visible, and fibril - like aggregates of the same protein may protect brain cells.»

Left: cells with large, fibril - like aggregates of SOD1 protein.

Laboratory studies also have largely failed to prove that large SOD1 fibrils are harmful to neurons.

An amyloid fibril is a large structure consisting of misfolded proteins.

In the past, he said, much research on Alzheimer's and similar disease focused on fibrils, large bundles of misfolded proteins that form in the brain.

Amyloid - β 42 (Aβ42) has a strong ability to oligomerize to form diffusible oligomers as well as larger polymers called fibrils that form insoluble amyloid plaques, a major hallmark of AD.