Sentences with phrase «larger trial using»

Wyss - Coray, whose group did most of the mouse studies that inspired the clinical trial, now plans to conduct a second, larger trial using plasma from which many proteins and other molecules have been removed.

The program will involve clinical trials testing for safety in humans, followed by a larger trial using non-human primates exposed to Ebola.

A large trial using EDTA given intravenously demonstrated clinical benefits.

Not exact matches

The 5G plan announced on Tuesday by the third - largest wireless carrier stands in start contrast to the emphasis from bigger competitors Verizon (vz) and AT&T, which are both running trials for fixed wireless Internet service using 5G to serve homes and businesses.

If large - scale trials can replicate safety and efficacy results, the drug could be approved for legal use by 2021.

In an early trial of this recipe I didn't have chocolate chips on hand so I did this as a backup plan, but I ended up really liking the texture the larger chunks of chocolate added so I kept using this method.

Previous trials included a very large plastic lidded basket intended for storing soiled cloth diapers that came complimentary from the diaper service we used when our first son was born.

Clearly, additional large randomize trials are needed to further understand the possibility of using probiotics to manage infant colic crying and which subgroup of infant could potentially profit from such intervention.

We used data from a large cluster - randomized trial to assess the impact of a breastfeeding promotion intervention on socioeconomic inequalities in breastfeeding (exclusivity and duration) and in child cognitive ability at early school age.

Most trials of prenatal home visiting have produced disappointing effects on pregnancy outcomes such as birth weight and gestational age, 9,16,17 although one program of prenatal and infancy home visiting by nurses has reduced prenatal tobacco use in two trials18, 19 and has reduced pregnancy - induced hypertension in a large sample of African - Americans.20

The program of prenatal and infancy home visiting by nurses described above produced treatment - control differences in 15 - year - olds» arrests and reductions in arrests and convictions among 19 - year - old females.32, 33 In a subsequent trial with a large sample of urban African - Americans the program produced treatment impacts on 12 - year - olds» use of substances and internalizing disorders.34

Despite aromatherapy's long history of use, there is still a lack of large - scale clinical trials exploring the effects of aromatherapy on anxiety.

In addition, there was no effect on breastfeeding duration when the pacifier was introduced at 1 month of age.280 A more recent systematic review found that the highest level of evidence (ie, from clinical trials) does not support an adverse relationship between pacifier use and breastfeeding duration or exclusivity.281 The association between shortened duration of breastfeeding and pacifier use in observational studies likely reflects a number of complex factors such as breastfeeding difficulties or intent to wean.281 A large multicenter, randomized controlled trial of 1021 mothers who were highly motivated to breastfeed were assigned to 2 groups: mothers advised to offer a pacifier after 15 days and mothers advised not to offer a pacifier.

The safety of the vaccine has been established in large clinical trials and will be continually monitored as it comes into wider use,» Ed Yong, health information manager at the charity told politics.co.uk

«If we find that lymphoscintigrams using tilmanocept are at least as good as the conventional radiocolloid tracer in identification and visualization of sentinel nodes, we would like to see a randomised clinical trial involving large numbers of patients,» says Prof de Bree.

As Scientific American reported earlier this year, more than half of the current cancer clinical trials do incorporate some form of immunotherapy but still oncologists are often only in the early stages of understanding how to use such treatment on a larger scale.

The team is now calling for a much larger clinical trial, involving one quarter of a million women, to investigate the effect of the screening using HPV testing on cancer rates.

However, it's not routinely used outside of clinical trials — in large part because it costs between # 4,000 (US$ 5,700) and # 7,000 for each recipient.

A statin drug commonly used to lower cholesterol is not effective in reducing the number and severity of flare ups from chronic obstructive pulmonary disease (COPD), according to the results of a large multicenter clinical trial designed and directed by Gerard J. Criner, MD, Director of Pulmonary and Critical Care Medicine at Temple University Hospital in Philadelphia, PA..

A large Australian trial showing that daily use of nicotinamide, a form of vitamin B3, for 12 months reduced the incidence of new non-melanoma skin cancers by 23 % in patients at high risk for skin cancer

The largest trial to date of «brain - training» computer games suggests that people who use the software to boost their mental skills are likely to be disappointed.

Young also hopes the results, which should be compiled by the end of the year, will provide enough preliminary evidence to help raise funds for a larger trial testing the use of social media to combat abuse of a broader number of substances.

Using simple statistics, without data about published research, Ioannidis argued that the results of large, randomized clinical trials — the gold standard of human research — were likely to be wrong 15 percent of the time and smaller, less rigorous studies are likely to fare even worse.

Dr Chris Gale is supported by a Medical Research Council (MRC) Clinician Scientist Fellowship to develop large, simple clinical trials that use routinely recorded electronic health record data held in the National Neonatal Research Database (NNRD).

Osaka University scientists found that some potential γ — secretase inhibitors such as semagacestat, which have been used in large clinical trials that ended in failure, do not function as true inhibitors as originally expected, but rather cause accumulation of toxic intraneuronal Aβ.

Fogerite said a larger randomized controlled trial would be needed to determine whether yoga could be used as a prescribed treatment for individuals with moderate disability due to MS.. More than 2.3 million people — two to three times more women than men — throughout the world are diagnosed with this disease which can cause poor coordination, loss of balance, slurred speech, tremors, numbness, extreme fatigue and problems with memory and concentration.

This is a very promising finding that provides an excellent basis for future larger scale trials using the intervention in very early development.»

* GRAIL plans to use the money to further develop the technology and to run the large clinical trials (involving hundreds of thousands of subjects) needed to see if screening will be feasible.

The study is believed to be the first and largest, multicenter, double - blind, randomized controlled trial of its kind to investigate the use of sublingual immunotherapy against ragweed allergy.

Westin launched his campaign last spring, and by the fall he had handed over management of his clinical trials — most recently testing the efficacy of a combination of three drugs used to treat large B - cell lymphoma — to colleagues.

Previous large ovarian cancer screening trials have used a fixed cut - off for CA125 (more than 35U / mL) to identify a possible abnormality.

As a result of the trial's findings, which confirm and expand on a recently published large clinical trial using the same software to inform treatment decision - making, thrombectomy procedures for late - arriving patients will probably double, said Albers, and this also opens up the prospect of using clot - busting medications well beyond the current 4.5 - hour window.

Researchers from the United Kingdom undertook an open randomized controlled trial to determine if autoinflation with a nasal balloon could be used on a large scale to benefit children in primary care settings.

In March, in their largest trial so far, they used a plastic tube 14 centimetres wide which reached from the surface of Lake Nyos to its bed, 208 metres below.

In an editorial accompanying the published article in Circulation, experts from the Technische Universität and the Munich Heart Alliance, Gjin Ndrepepa and Adnan Kastrati, affirmed that, if confirmed by a subsequent analysis of large numbers of patients, the results of METOCARD - CNIC trial are likely to lead to a change in clinical practice: «In this regard, a pharmaco - protective strategy able to reduce infarct size by 20 percent when used in conjunction with primary PCI nurtures great hope in clinical benefit.»

The researchers drew patients from a large trial focusing on the use of CCTA in people who had come to the emergency department with acute chest pain.

A disease as variable as ALS requires costly clinical trials to make this comparison using a large control group.

Spigelman cautions, however, that larger trials are needed to confirm the effectiveness of both therapies and for them to be approved for global use.

«Based on this study, we're now conducting a larger trial to measure the impact of virtual reality on the use of pain medications, length of hospital stay and post-discharge satisfaction scores,» Spiegel said.

This study was designed to use readily available agents in an accepted large - animal model of human heart attack with the goal of obtaining evidence that this treatment is ready to be moved into human clinical trials.»

They estimate that using these algorithms to predict outcomes could allow a drug sponsor to reduce the size of the trial by at least 20 % and save as much as $ 6 million in a large phase III trial.

Ashikaga cautions that larger - scale clinical trials are needed before the measurement can be recommended for wider use.

Acetazolamide has been used for decades as a respiratory stimulant for patients with COPD and metabolic alkalosis (an increase in the alkalinity of body fluids due to an increase in alkali intake or a decrease in acid concentration), but no large randomized placebo - controlled trial has been available to confirm this approach.

In this study, researchers used blood samples collected several years before breast cancer development from two large UK cohorts of women — the MRC National Survey of Health and Development and the UK Collaborative Trial of Ovarian Cancer Screening.

But the findings do provide researchers with ample evidence to pursue funding for larger clinical trials and to use the drug as a lead for future drug development, they said.

«More studies are warranted to confirm the deleterious effect of antibiotic use in large prospective trials and to develop novel diagnostic tools based on gut microbiota in cancer patients, to predict response / resistance to ICIs and identify the key microbiota signatures for each tumor site,» the researchers wrote.

These findings are generally consistent with those from recent systematic reviews, some of which also included trials of statins for secondary prevention.47,51 - 53 Similar to other meta - analyses of primary and secondary prevention trials, 54,55 this review found no association between use of statins and increased risk of muscle - related harms, although some observational studies and randomized rechallenge trials found statins associated with increased risk of myopathy or joint - related symptoms.56 - 58 The large HOPE - 3 trial found statins associated with increased risk of cataract surgery, an unanticipated finding.14 No other trial of statins for primary prevention evaluated risk of cataracts or cataract surgery.

Using the large patient group in the ProTECT III trial, the researchers hope to validate promising TBI biomarkers as predictors of clinical outcome and also evaluate the relationship between progesterone treatment, biomarker levels and outcome.

Although these platforms can be used successfully for small - scale expansion of hMSCs, other platforms will be required to generate the quantity of cells required to support the increasing number of clinical trials utilizing hMSCs and the subsequent large - scale production.

take a lead in developing the next generation of cancer cell lines and use cell lines to systematically explore in vitro sensitivity to large numbers of anticancer drugs and drug combinations in order to inform choice of cancer types for early drug trials.