Sentences with phrase «larger trials of»

Second, while the small sample size that accompanies an open trial is a limitation, our findings were statistically significant, with large effect sizes that are comparable to larger trials of standard PCIT.

The small, phase 1 trial enrolled 11 patients and found that side - effects were similar in this population as previously reported in larger trials of enzalutamide against prostate cancer.

A large trial of supplements is due to finish in July, but a smaller one, in which 36 people took a pill containing all three pigments every day for six months, has already yielded positive results.

Several large trials of amyloid - based therapies are underway in groups of people more carefully selected to be at high risk for Alzheimer's.

«To the best of our knowledge, this is the largest trial of a perioperative, cardiac output - guided hemodynamic therapy algorithm to date.

He points out that the largest trials of antihypertensive therapy and statins for people in this age group have shown only a marginal reduction in stroke and very modest reductions in other cardiovascular events.

The first reviewed three large trials of multivitamins and 24 trials of single or combined vitamins involving over 400,000 people.

«Phase 1 results point to larger trial of enzalutamide and fulvestrant in breast cancer.»

«There are a lot of questions about how to implement it,» says Connie Celum, an HIV researcher at the University of Washington in Seattle, who led a large trial of the drug in East Africa and has begun studies to answer practical delivery questions, such as which subsets of people are at highest risk.

«These data support moving forward with a larger trial of the enzalutamide plus fulvestrant combination.»

Gordeuk and his colleagues are also planning a larger trial of desferrioxamine in 300 children with cerebral malaria.

Dr. Azad is a national leader in GI cancer, including serving as a member of the national NCI Colon Cancer Task Force and the NCI MATCH (Molecular Analysis for Therapy Choice) Agents and Genes Working Group, the largest trial of personalized medicine in the country.

The study, 11 conducted from 1968 to 1973, included 9,423 participants between the ages of 20 and 97, making it the largest trial of its kind.

Recently, raw, unpublished data from a double blind, randomized controlled trial conducted between 1968 and 1973 with ten thousand participants, making this the largest trial of its kind, was re-reviewed.

ADHD students given methylphenidate combined with psychosocial treatment showed significant improvement in classroom behavior and academic performance in what is being called the first large trial of the effects of multiple doses of methylphenidate on the behavior and performance of young teens in a classroom setting.

Not exact matches

While the new mid-stage study results from DNDi were impressive (they showed cure rates of 96 % to 97 % even for the sickest patients and those with liver scarring), more late - stage trials will be necessary before the drug is available on a large scale in the developing world.

Just this month, as part of the first large - scale clinical trial of its kind, researchers working in rural India found that newborns who were given a synbiotic were at a substantially lower risk of developing sepsis, a potentially fatal condition characterized by severe infection.

Some small studies have suggested that synbiotics could provide benefits to a range of other conditions influenced by the gut microbiome as well, including obesity, diabetes, and non-alcoholic fatty liver disease, but larger - scale clinical trials focusing on each of those conditions are needed.

Currently in the U.K., he will go back to Privateer's headquarters in Seattle, then visit Tilray's 60,000 - square foot facilities in British Columbia, Canada, then to Australia, where Tilray has an import license to send marijuana for a clinical trial with a chemotherapy - induced nausea and vomiting study with the University of Sydney, the government of New South Wales and the country's largest cancer hospital.

Residents at Alkimos Beach and White Gum Valley are set to participate in trials of solar energy technology and battery storage that could lead to large reductions in power bills.

Years of trial and error have taught me that I prefer to eat much larger infrequent meals and not to start eating until later on in the day.

In a surprising twist, Merck's anacetrapib, a heart disease drug, produced strong results in a large clinical trial of 30,000 patients, according to the company.

David Sanford, chairman of Sanford Heisler Sharp, the law firm that argued the largest - ever employment gender discrimination case to go to trial — a class action suit against Novartis Pharmaceuticals that resulted in a $ 253 million jury award for plaintiffs in 2010, reduced post-trial to $ 175 million — noted that in that case, the company had just three investigators for a workforce of thousands.

Even if just a trial, the development represents a stunning milestone considering the capital and resources that other, much larger companies have dedicated to the development and eventual commercial deployment of a self - driving taxi service.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Announced a clinical trial collaboration with Pfizer, Inc. (Pfizer) to evaluate the safety and efficacy of the investigational combination of Yescarta and Pfizer's utomilumab, a fully humanized 4 - 1BB agonist monoclonal antibody, in patients with refractory large B - cell lymphoma.

We talk with two pioneering physicians — one of whom is overseeing the world's largest HIV vaccine trial and the other led a groundbreaking successful pilot in the U.S. — to see how far we are from getting to zero.

Grail, a year - old, Menlo Park, Ca. - based early cancer screening startup that spun out of the DNA - sequencing giant Illumina is reportedly looking to raise up to $ 1.7 billion in fresh funding to launch a large - scale clinical trial.

The results, which mirror those of similar, small - scale studies of the illegal drug in recent years, come as MDMA is about to enter larger, Phase 3 trials this summer.

Some of Japan's largest companies, including Samsung and Deutsche Telecom, picked up on Evernote's loyal following and began preloading their devices with the platform, shelling out huge sums to offer their customers pre-paid one - year Evernote trials.

The adaptive pathways concept applies primarily to treatments in areas of high medical need where it is difficult to collect data via traditional routes and where large clinical trials would unnecessarily expose patients who are unlikely to benefit from the medicine.

One of Juno's rivals, Kite Pharma, yesterday said it had completed its enrollment of 72 patients with diffuse large B - cell lymphoma in the Phase II portion of the ZUMA - 1 trial, designed to assess KTE - C19.

Instagram got trial access to solid - state drives on the EC2 cloud - computing platform before that option became generally available, one of the perks of being a large customer, Krieger said.

Dr. Newman added that rival CAR T cell therapy developer Kite Pharma was still likelier to generate more revenue than Juno with KTE - C19, which last week completed patient enrollment in the Phase II portion of the ZUMA - 1 trial in patients with diffuse large B - cell lymphoma.

Prophecy Resource (TSX.V: PCY) has begun production of its first 10,000 tonnes of coal as a trial run of supply to be taken by rail to electric power stations in Darkhan and Erdenet, Mongolia's second and third largest cities after the capital, Ulaanbaatar.

As the trial of the head of one of South Korea's largest conglomerates on corruption charges got underway, the president's ousting meant she lost her immunity to prosecution over the corruption scandal that forced her from office.

The second reason is that Amarin will finally announce the top - line results of its large cardiovascular outcomes trial for Vascepa sometime in the third quarter of 2018.

Although Lu - PSMA - 617 put up good numbers in its small single - arm study, it still needs to outperform a physician's choice of approved treatments in a much larger global trial.

The truth is that, during the twentieth century, large parts of the world have given the collectivist alternative to capitalism a long, thorough, and staggeringly costly trial, and it seems to have failed absolutely everywhere.

Recent sex discrimination cases resulting in large settlements, in some cases awards of multi-million dollars, to be split with aggressive trial attorneys, are the latest examples of misusing the Civil Rights Act of 1964.

Carefully, he put a large sum of money away where no one could touch it and then faced trial.

«The two largest groups containing prisoners in the camps, both numbering in the millions, were the Polish Jews and the Soviet prisoners of war (POWs) held without trial or judicial process.

In an early trial of this recipe I didn't have chocolate chips on hand so I did this as a backup plan, but I ended up really liking the texture the larger chunks of chocolate added so I kept using this method.

The company then analyzes the different varieties, and the varieties that are successful will be planted in a larger trial consisting of several acres, and tested in different growing areas.

Whilst smaller size bottles encourage trial of products and categories, 48 % of people buying a 35 cl bottle will only purchase this smaller size and not larger variants

I came upon my ratios thru trial and error and made alot of choco sauce in the process but came upon that ratio that works, and it's interesting, yours is the same, just larger quantity.

Our highly skilled technicians combined with our laboratory - scale processing equipment reduce the need for large plant trials and accelerates the development of your product and speed to market distribution.

He contributes to other large - scale clinical trials including SAVE (evaluating whether treatment of obstructive sleep apnoea with continuous positive airways pressure can reduce the incidence of serious CV events in patients with established CVD), and CREDENCE, a randomised, double - blind, placebo - controlled trial assessing whether canagliflozin can slow the progression of diabetic nephropathy in patients with type 2 diabetes.

It's also a game that became dangerous for me when it introduced online rankings, as I could not stop playing once I noticed where I ranked in North America on time trial courses from the Wii edition — it was that experience with the time trials mode from my youth all over again, except instead of just besting myself and my dad and a couple of friends, it was a large percentage of a continent that I'm embarrassed to even quote here as it will give away just how time I spent with the game.

Three years of brilliant performances make Jones the 100 - and 200 - meter favorite at the trials, especially with Miller — who has not looked sharp in recent European races — saying last week that she is running merely to make the team in Sacramento, with victory in Sydney as her larger goal.