Sentences with phrase «largest gene family»

At around 1,800 genes, it is the second - largest gene family to be discovered in an animal, after the elephant's 2,000 olfactory - receptor genes.

The octopus genome contains around 1,800 C2H2 zinc finger transcription factors, the second largest gene family so far discovered in animals (olfactory receptor genes in elephants are the largest at around 2,000).

To answer these questions, Senior lecturer Xiao - Ru Wang and colleagues examined the signature of selection among members of a large gene family, the glutathione S - transferase (GST) in pine genome.

Not exact matches

The gene aquaporin - 1 encodes channel - forming integral protein (CHIP), a member of a large family of water transporters found throughout nature.

A team led by Margaret Pericak - Vance of Duke University, Jonathan Haines of Vanderbilt University in Nashville, Tennessee, and Allen Roses — a former Duke researcher now in charge of genetics research at the Glaxo Wellcome Company in Research Triangle Park, North Carolina — scanned the DNA of members of 16 large families with a high rate of Alzheimer's, looking at 280 genetic markers that might help identify candidate genes.

The researchers also found that wtf4 is a member of a large family of selfish genes, and that at least one other wtf gene also causes meiotic drive, suggesting that the family proliferated due to meiotic drive.

Although there is no direct test yet, women in some families with large numbers of cases can be tested for known genetic markers that are inherited alongside the gene.

But you asked me right, the importance of gene duplication; most — I say, most, [which] is a rough number — but a very large number of the genes that carry out functions in our body are parts of [the] family of the genes, members of [the] family of the genes that have expanded by gene duplication.

Bierut and her colleagues analyzed data gathered through the Collaborative Study on the Genetics of Alcoholism (COGA), a large, multi-center, family study designed to identify genes that contribute to AUDs.

The protein studied in the mold is part of a larger family of proteins also found in humans and involved in many essential biological processes including gene regulation and fatty acid metabolism.

The study found that 8,600 families of genes are shared across deuterostomes, a large animal grouping that includes a variety of organisms, ranging from acorn worms to star fishes, from frogs to dogs, to humans.

Traditionally, geneticists have hunted down genes by tracking the inheritance of a genetic disease through large families or by searching for suspected problematic genes among patients.

Through the study of a large family with TAAD features, an international team of genetic researchers have now discovered that a mutation in the TGFB3 gene is also responsible for the condition.

For a decade, the group at North Carolina has studied a large family of genes in mice called L1, some of which are dormant.

The earlier discovery of mutations in UBQLN2 gene, which causes ALS and ALS / dementia in children and adults, in the Siddique lab led to the screening of the UBQLN family of genes in a large cohort of patients with familial ALS, resulting in the identification of the UBQLN4 mutation.

For instance, in the human genome we still see the remnants of the large olfactory receptor gene family that gave our evolutionary ancestors a keen sense of smell, even though humans no longer rely on them.

Right now, researchers must haplotype by analyzing genetic material from large families, or in their absence track gene frequencies in lots of individuals, a statistical process that is «prone to error,» says geneticist Andrew Collins of Southampton University in the United Kingdom.

Instead, they helped Myriad Genetics, the company that studied those tissues, to establish broad gene patents and achieve large profits by selling tests that many donor families could not afford.

Trying to narrow the site of the mutation, gene mapper Hans Eiberg of the University of Copenhagen and colleagues examined members of a large Danish family, an approach that allowed them to follow DNA as it passed from one generation to another.

Another 41 families carried mutations in a larger set of genes whose role in cancer is «emerging,» Walsh said.

The study focused on a small subset of nuclear receptors, a large family of proteins that regulate gene expression in response to signals from various binding partners, including steroids and fats.

It was so large that we actually treated it as two distinct families, because we thought there were two genes.

This approach, which relies on a few large families, can produce misleading results for a disorder such as ADHD which may involve several genes, unlike single - gene disorders such as cystic fibrosis or Huntington's disease.

In the most detailed large - scale study to date of the proteins that package DNA, researchers have mapped a family of switches that turn genes on and off.

The genome encodes a large number of novel receptor kinases and contains expansions of a variety of gene families, including those associated with virulence.

Many species - specific genes, especially large surface antigen families, occur at nonsyntenic chromosome - internal and subtelomeric regions.

The evolution of mammalian genomes is thought to include at least two whole genome duplications of an ancestral genome (Holland et al., 1994), as well as duplication of sub-chromosomal segments together with extensive gene duplication that has given rise to many large multigene families (Lundin, 1993).

The largest multigene family in P. cynomolgi comprises pir genes.

Additional gene duplication and divergence in eumetazoans further increased transcription factor gene family number, which in general are 2 to 34 times larger in eumetazoans than in Amphimedon.

Like many scientists, we think that gene silencing is the most promising approach to developing meaningful therapies for HD families, and it's gratifying that large companies are willing to make a large financial investment in the therapy.

Friday, Oct. 20, 5:30 - 5:50 p.m., South Hall B, South Building Featured Plenary Abstract: The contribution of rare variants, polygenic risk, and novel candidate genes to the hereditary risk of breast cancer in a large cohort of breast cancer families N. Li, Peter MacCallum Cancer Center, et al

Whilst a number of genes have been identified previously from investigation of families with Mendelian inheritance patterns, sequencing the DNA from large cohorts of individuals with congenital heart disease is now providing fresh insights into the genetics of these conditions.

Nicki provides unique insight into being part of a large Italian - American family afflicted with the BRCA2 gene, and shares poignant stories about her mother and aunts who faced breast and ovarian cancer with extraordinary grace and courage.

Only then somebody asked dad for help, because he was considerably larger than the other men of the family, courtesy of his freakishly tall American genes.

The study was among the first to use large - scale DNA sequencing to systematically analyze all 86 members of the PTK gene family in melanoma samples.