Sentences with phrase «largest genomic study»

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EPFL scientists have carried out a genomic and evolutionary study of a large and enigmatic family of human proteins, to demonstrate that it is responsible for harnessing the millions of transposable elements in the human genome.

«We now hope to design larger clinical studies to treat patients» tumors harboring these novel genomic aberrations to further explore the precise extent of clinical benefit for patients with primary or advanced cholangiocarcinoma.»

Those who heard the talk in a packed auditorium at the University of Basel were impressed by the genomic data's high resolution — it is the largest data set of ancient DNA ever presented in a single study — even though some aren't convinced about the exact details.

In a Q&A, Dishman explained why he thinks he got the job, even though, as Kaiser pointed out, he «does not have a background in genomics or large, long - term health studies, nor even a Ph.D.» «I think I'm a weird mix of a bunch of different capabilities that they need,» Dishman said.

Large - scale genomic studies will probably uncover more gene variants associated with increased risk of developing PTSD, says de Quervain, and may provide a better understanding of the molecular mechanisms involved.

The study is the largest and most ethnically diverse genomics study of multiple myeloma to date, the researchers said.

Ioannidis says that researchers have become increasingly sophisticated at acquiring large amounts of data from genomics and other studies, and at spinning it in different ways — much like TV weathercasters proclaiming every day a record - setting meteorological event of some sort.

The advent of genomics and rapid sequencing techniques has seen HeLa cells used in numerous large - scale studies of gene function and expression.

The large - scale genomic study of the Scandinavian wolf population is reported in Nature Ecology & Evolution.

Moreover, they have re-used large amounts of data from previous genomic studies and analysed them again with new and better methods.

This deficit in African ancestry genomic data was identified during an 18 - month long study conducted under the auspices of the larger Consortium on Asthma among African - Ancestry Populations in the Americas (CAAPA).

Also, a number of large - scale genomics studies have linked variants of the CPEB4 gene with the impairment of fat metabolism.

Furthermore, the large volume of data obtained from their study, which was deposited into a public genomics data repository, provides a wealth of information available to other researchers to accelerate ALS research.

Researchers leading the largest genomic tumor profiling effort of its kind say such studies are technically feasible in a broad population of adult and pediatric patients with many different types of cancer, and that some patients can benefit by receiving precision drugs targeted to their tumors» mutations or being enrolled in clinical trials.

«Metabolomics is now often used to accompany large genomic cohort studies from biobanks, to correlate genotype and genomic variants with specific phenotypes, to complement nutritional studies monitoring food components or endogenous metabolites, or to support measurements in epidemiology studies,» says Andreas Huhmer, director of proteomics and metabolomics marketing at Thermo Fisher Scientific, headquartered in Waltham, Massachusetts.

The objective of this study is to validate the diagnostic performance and practical feasibility of massively parallel genomic sequencing for the non-invasive prenatal assessment of trisomy 21 in a large number of pregnancies that have undergone conventional screening and were clinically indicated for definitive testing by amniocentesis or chorionic villus sampling.

A large - scale genomic study uncovered novel genetic variants and led researchers to an unexpected gene that affects bone density and fracture risk.

A secondary goal of the study was to develop laboratory protocols to improve the throughput of massively parallel genomic sequencing for handling large sample numbers.

Large - scale genomic studies have shown that half of epithelial ovarian cancers (EOCs) have alterations in genes regulating homologous recombination (HR) repair.

In fact, this study reports the largest scale use of massively parallel genomic sequencing (so called next generation sequencing) for medical diagnostics to date and shows that it is practically feasible on a large scale.

Two large - scale studies reveal new insights into the genomic characteristics of childhood cancers.

$ 25M was committed by NHGRI to its Large - Scale Sequencing and Analysis Centers (LSACs) for genomic studies.

We hope that the easy availability of these large datasets will be useful to many yeast (and non-yeast) researchers, and as the authors say, will help to «guide future population genomics and genotype — phenotype studies in this classic model system.»

Led by Charis Eng, M.D., Ph.D., Hardis Chair of the Genomic Medicine Institute and Director of its Center for Personalized Genetic Healthcare of Cleveland Clinic, the study — the largest clinical study to date on the identification of PTEN — involved 3,042 participants, including both adults and children.

Ageing research and more generally the study of the functional basis of human diseases profit enormously from the large - scale approaches and resources in mouse functional genomics: systematic targeted mutation of the mouse genome, systemic phenotyping in mouse clinics, and the archiving and distribution of the mouse resources in public repositories.

For many human diseases, large - scale genomic studies have identified common genetic variants that occur more frequently in people with cardiovascular, autoimmune, inflammatory and infectious diseases, diabetes and asthma than in those without these diseases.

In a large - scale genomic study, published in Science today, a team of researchers led by Uppsala University found that this behaviour might be rooted in their genetic make - up, revealing a likely common evolutionary path that allows for separating populations into novel species.

Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival.

Large - scale genomic studies on other chlamydial species are giving insights into the biology of these organisms but have not yet been performed on C. abortus.

It concludes that Neanderthals were more numerous than previous genetic studies often supposed, perhaps finally aligning genomic findings with the larger populations extrapolated from artifacts and fossils.

The branch serves as a focal point at the NIH campus for the analysis of a wide variety of large - scale genomic data generated in the course of laboratory and clinical studies, with branch members actively involved in efforts aimed at developing new bioinformatic approaches for the analysis and visualization of these data.

However, following the flourishing of large - scale genomics, several studies have investigated CNVs across the whole chromosome.

By focusing on a specific set of case studies to which genomic techniques might be applied we will be able to drill down on these scientific challenges but also open the larger conversation about the rights and responsibilities of these new technologies.

Epidemiologic research is of increasing importance in the era of large scale genomics and databases, where large numbers of patients must be accumulated to study subtle individual effects that translate into large population effects.