Sentences with phrase «largest placebo»

Although it included just 326 patients, the study is the largest placebo - controlled trial to date on antidepressants in people with dementia.

«Testosterone therapy improves sexual interest, function in older men: Largest placebo - controlled study to date finds testosterone can address low libido, erectile dysfunction.»

The study is the largest placebo - controlled trial in older men conducted on the subject to date.

A larger placebo - controlled clinical trial, sponsored by the National Institute of Mental Health (NIMH), is now underway.

Furthermore, randomized controlled trials of antidepressants consistently demonstrate large placebo effects.

Not exact matches

But a large 2011 study of close to 36,000 men found that the risk of prostate cancer actually increased among the men taking Vitamin E compared to the men taking a placebo.

A large new meta - analysis of antidepressants suggests that they do actually work, at least when compared with placebo, in treating depression.

It may have to do with Addyi's high pricing (on par with Viagra at $ 26 per pill without an assistance program), its daily intake requirement (unlike Viagra, it adds up to $ 780 per month), its potentially deleterious side effects (low blood pressure and fainting), its restrictions on alcohol consumption (abstinence vs. large quantities not recommended for Viagra patients), a 10 % efficacy rate (whereas Viagra works 50 % of the time compared to a placebo, according to a recent study), and its subtle neurotransmitter - targeting mechanism (contrast that to the obvious hydraulics of Viagra).

He contributes to other large - scale clinical trials including SAVE (evaluating whether treatment of obstructive sleep apnoea with continuous positive airways pressure can reduce the incidence of serious CV events in patients with established CVD), and CREDENCE, a randomised, double - blind, placebo - controlled trial assessing whether canagliflozin can slow the progression of diabetic nephropathy in patients with type 2 diabetes.

As it turned out, subjects who experienced the largest change in the mu - opioid system between the placebo injection and the painful one tended to report the least pain.

But those results didn't hold up in a larger group of 139 patients randomized to take opioids or placebo, nor did they appear in a different pain test that applied a gradually heated probe to the forearm.

Researchers leading a large, ongoing study in women called VOICE that compares PrEP with pills to a vaginal microbicide plan to revaluate the ethics of continuing to use a placebo control group given the new evidence of oral Truvada's powerful impact.

In a series of short - term placebo - controlled trials, researchers at Ben Gurion University of the Negev in Israel found that large doses of inositol — 12 to 18 grams a day — helped alleviate depression, panic disorder, and obsessive - compulsive disorder.

In a landmark 1999 study, Harvard psychiatrist Andrew Stoll found that bipolar patients who were given large doses of omega - 3s did significantly better and resisted relapse longer than a matched group of patients who were given placebos.

Participants who took the largest 10 - mg dose showed less decline on one of two memory tests than those receiving lower doses, or the placebo.

He argues that «placebos at large», constructed...

Results of the second, larger study were nearly as impressive: 38 percent of patients who took baby aspirin developed new polyps, compared with 47 percent of patients taking the placebo.

1) Placebo (an inert pill) 2) Omega - 3 [specifically docosahexaenoic acid (DHA, 350 mg) and eicosapentaenoic acid (650 mg)-RSB- 3) Lutein and zeaxanthin (nutrients found in large amounts in green leafy vegetables) 4) Omega - 3 and Lutein / zeaxanthin

Yale enrolled the largest number of participants at any one site (84 of 790) for these double - blind, placebo - controlled trials that investigated the efficacy of testosterone gel for multiple outcomes, including sexual function, physical function, and vitality.

He argues that «placebos at large», constructed by big government and religion, help us overcome our overcautious nature, which evolved when big threats were more common.

Lloyd - Jones's editorial is based on a large new study published in the journal that looked at adults, ages 50 to 80, with cardiovascular disease who took extended - release niacin (vitamin B3) and laropiprant (a drug that reduces face flushing caused by high doses of niacin) to see if it reduced heart attack and stroke compared to a placebo over four years.

Contrary to the proclamations of many scientists, unreliable medical study results do not disappear with large, randomized controlled trials, in which subjects are randomly assigned to a treatment or placebo group.

«This was the first large, double - blind, randomized, placebo - controlled trial to assess whether giving intravenous beta blockers before these patients undergo angioplasty would further improve their outcomes.

The Physicians» Health Study II (PHS II) remains the only randomized, large - scale, long - term trial to test whether a daily multivitamin reduced cardiovascular disease risk, and researchers found that after 11 years of follow up, there was no significant difference in risk of major cardiovascular disease (CVD) events among men who took a multivitamin compared to those that took a placebo.

And it remains true that no homeopathic remedy has ever been shown to work in a large randomised placebo - controlled clinical trial.

Acetazolamide has been used for decades as a respiratory stimulant for patients with COPD and metabolic alkalosis (an increase in the alkalinity of body fluids due to an increase in alkali intake or a decrease in acid concentration), but no large randomized placebo - controlled trial has been available to confirm this approach.

While second - stage results showed no significant differences between participants continuing to receive weekly doses of the active drug, those receiving biweekly doses and those shifted to placebo, Kimball notes that, since it is typical for the severity of HS symptoms to increase and decrease and because the study protocol required treatment discontinuation for participants whose symptoms stopped responding to the drug, larger scale studies will be required to better define the ideal length and frequency of treatment.

Maharaj and Trevino call for larger, placebo - controlled studies of potential treatments for PMDD.

«Both physical functioning and quality of life are severely affected, and while many treatments are used to relieve symptoms and try to get the disease under control, this largest set of placebo - controlled information to date clearly shows that improvement can result for patients.»

A cosmetics industry representative interviewed for this story pointed out that the EWG report «lacks many of the rigors that you would normally associate with a real scientific report,» such as a large study population and control or placebo groups.

In the new study, the largest of its kind to date, the researchers randomly assigned 369 U.S. and Canadian men with prostate - related symptoms to take saw - palmetto capsules or an identical placebo.

The study looked at the effect of dietary supplementation using 2,000 international units of nonprescription vitamin E daily in a large group of elderly Alzheimer's patients and compared their results over an average of around two years to similar patients who received a placebo, a pharmaceutical marketed as a «treatment» for Alzheimer's disease (memantine), or a combination of memantine along with vitamin E.

Another explanation: The size and length of the clinical trials in the U.S. were larger, factors associated with bigger placebo responses, though researchers don't know why.

The outcomes of this preliminary study have resulted in the implementation of larger, placebo - controlled clinical studies to assess if individuals with heart failure as well as diabetes show improvement in their exercise capacity when given epicatechin - rich cocoa.

Overall, the difference in weight loss between the pyruvate supplement and placebo groups was not large, amounting to approximately 1.1 - 1.6 kg (about 2 - 3 lb) additional weight loss in the pyruvate groups.

One large randomized, double - blind, placebo - controlled trial showed that MYO (4 g / day) for 14 weeks, increased HDL («good» cholesterol) levels and resulted in significant weight loss (and decreased leptin levels) in women with PCOS, although no change in insulin was detected.

The National Cancer Institute is conducting a large study combining vitamin E and selenium alongside a placebo test in men aged 55 or older to see if the combination protects against prostate cancer.

The National Cancer Institute is conducting a large study combining vitamin E and selenium, a mineral found in walnuts, alongside a placebo test in men aged 55 or older, to see effects on prostate cancer incidence.

While promising, large - scale placebo - controlled clinical trials in patients with neurological disorders are still lacking.

Their larger 2013 placebo - controlled, double - blinded, crossover study found LDN improved mood but did not help with sleep or fatigue.

A double - blind flight simulation study assessing motor performance in licensed pilots «flying» through pre-specified (and practiced) holding patterns showed that smoking marijuana significantly increased major and minor errors, and led to larger average deviations from the assigned flight sequence, compared to those who smoked placebo cigarettes.

Both ladies were extremely motivated and dedicated to the n = 1 experiments «wanting» the intervention to work — hence placebo effects may play a large role in the self - reported improvements.

Initial studies showed that patients taking testolone saw a large increase of muscle mass that was not found with the placebo group.

In a larger study, adults with multiple risk factors and LDL choles - terol concentrations above 4.14 mmol / L or between 3.37 and 4.14 mmol / L were randomized to one of seven groups to receive either oatmeal or oat bran at various levels or a placebo control (Davidson et al., 1991).

In the pilot study, 30 large, middle - aged dogs will be involved — half receiving low doses of rapamycin, half receiving placebos.

Millions of women stopped using the hormones after a large U.S. government study in 2002 found that postmenopausal women given HRT had higher risks of heart attack, stroke, breast cancer and blood clots than women given an inactive placebo.

Specifically, as Figure 2 shows, improvement from baseline operated as a ∩ - shaped curvilinear function in relation to baseline severity, with those at the lowest and highest levels experiencing smaller gains, whereas those in - between experienced larger gains; the slope for placebo declined as severity increased, whereas the slope for drug was slightly positive.

Although venlafaxine and paroxetine had significantly (p < 0.001) larger weighted mean effect sizes comparing drug to placebo conditions (ds = 0.42 and 0.47, respectively) than fluoxetine (d = 0.22) or nefazodone (0.21), these differences disappeared when baseline severity was controlled.

In addition, children with ASD respond equal to placebo as to specific drugs, while adverse effects of these drugs are larger (King et al. 2009).