Sentences with phrase «largest timed cycle»

An event so popular that riders from 60 countries turn up for what is the billed as the «largest timed cycle race in the world».

Not exact matches

They hope to be able to amass enough data about women's menstrual cycles, sexual behavior, mood, and diet that they can help any woman know exactly when to conceive, warn her about early problems like potential endometriosis, and over time, promote better health care for women in general by collecting large amounts of information that hasn't been collected before.

Armed with the facts about long sales - cycle times, he has modified his plan to focus on building a larger sales team and putting more prospects in the pipeline.

This positive cycle allows them to justify large capital investments in their facilities and provide substantial returns for their shareholders, as share prices for these global companies are at all - time highs.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

The Balanced Asset Class Index which included large caps, small caps, value stocks and bonds fared much better than the all - stock options and outperformed the other options over the full cycle 4 out of 5 times.

For example, we can predict that no major government attacks on corporate success are likely from the time of a stock market bottom of Cycle degree or larger through most of the ensuing bull market.

The large rise in real wages at this time explains why the unemployment rate indicates a deeper and longer recession than the other indicators of the cycle.

And the largest bicycle manufacturer in the world by sales is Giant from Taiwan with 1.8 bn sales or 7,5 times the sales of Hero cycles.

Although global warming may now be a serious concern, it is likely that long - term climate cycles will cause large ice sheets to return at some time in the distant future, and cataclysmic outburst floods will probably recur in this region.»

Even in those circumstances where a loan proves successful, and there is right to buy clause, it will eat a large hole in the transfer kitty for the following summer, for a player that you already have, leaving no option but for the cycle to repeat next time around when further improvement is required.

This finding was replicated in the second cycle of the study (CIS 2003).40 Another large Canadian study41 found that children who were spanked by their parents were seven times more likely to be severely assaulted by their parents (e.g., punched or kicked) than children who were not spanked.

Due to the fact that Android systems are so diverse and fragmented and that Android systems have a notoriously long update cycle (typically due to the hold time at mobile carriers), the window of vulnerabilities is typically very large.

The team compiled data from many studies and for the first time synthesized observations and numerical model output to develop a cohesive view of the carbon cycle in a large coastal region.

The timing of this decline correlates with environmental changes associated with the onset of the last glacial cycle, the team reports, whereas archaeological evidence does not support the presence of large populations of humans in eastern Beringia until more than 15,000 years later.

Elliott Main, M.D. who is the medical director of the CMQCC and the presenter of the study at the SMFM annual meeting, explained, «The keys for success were (1) multi-partner engagement, (2) rapid cycle data and (3) use of a novel quality improvement model involving pairing physician and nurse mentors working with five to eight hospitals at a time, all within the construct of a large statewide project.»

«That means water must have recycled through the valley systems on Mars many times, and a large open body of water or ocean is needed to facilitate such active cycling,» Luo said.

At any given instant it can be argued that the cell is in a «state» defined by its components — their concentrations and locations, the interactions between components — that are modulated in space and time, and the complex circuitry — that involves a large number of interacting networks and a snapshot of the dynamical processes — such as gene expression, cell cycle, transport of components, etc..

M2009 use a simplified carbon cycle and climate model to make a large ensemble of simulations in which principal uncertainties in the carbon cycle, radiative forcings, and climate response are allowed to vary, thus yielding a probability distribution for global warming as a function of time throughout the 21st century.

In the process of exploring how the liver's daily cycles work, Panda found that mice which eat within a set amount of time (12 hours) resulted in slimmer, healthier mice than those who ate the same number of calories in a larger window of time, showing that when one eats may be as important as what one eats.

Studies show women with a larger waistline is more prone to secrete cortisol at the time of stress, creating a recurring cycle (9).

It warns LED street lights are five times more disruptive to the human sleep cycle than traditional street lighting and that recent large surveys link brighter residential lighting with reduced sleep, poor functioning, and more obesity.

Not only do fertility trackers motivate you to log your body's rhythms and changes throughout the month, but they can help you see larger patterns in your cycle, too — and that's info that your doctor will love to have on hand the next time you're in for a checkup.

To Hramiec's point, this fuels a vicious cycle when it comes to competency models spreading: if a small minority of fully competency - based schools can not spur a supply of integrated competency - based technology solutions, it is unlikely that larger systems, whose demand ultimately drives the edtech market, will move away from time - based practices.

That's a long time in modern cars years — a whole product cycle — and its absence will either steer buyers higher up in the range to the larger QX60, or down to the QX50.

Using less than 20 % of your available credit card limit each billing cycle (yes, even if you pay your balances in full and on time), paying down loans with large balances and making all your loan payments on time are easy ways to improve your credit score.

It is very costly to be stuck in a payday loan cycle for a long time and can lead to larger financial problems.»

When it comes to purchasing securities traded on an open market, a decision to invest a large sum all at once can expose you to the risk of buying at an inopportune time in the market cycle.

Currently there are 50 stocks that make the cut, all of which are high quality, have large moats that have allowed them to continue to prosper during all points of the business cycle, even raising dividends during times of recession.

Using less than 20 % of your available credit card limit each billing cycle (yes, even if you pay your balances in full and on time), paying down loans with large balances and making all of your loan payments on time are easy ways to improve your credit score.

It is very costly to be stuck in a payday loan cycle for a long time and can lead to larger financial problems,» according to Credit.com.

The onset of the first heat cycle, when a female can become pregnant, follows the same time frame as puberty (4 to 6 months) for cats and small dogs, though it may be delayed until 18 to 24 months in larger breeds of dogs.

Litter Robot: the most suitable version is the Litter Robot Open Air because it has adjustable cleaning cycle times, the waste chamber it's a little larger than previous versions and it has been designed thinking about multiple cats.

What I was concerned about is her coming in heat, we do not want to breed her, but our Vet said that «They — have researched spaying the larger breeds of dogs before they go through one or two heat cycles, and found out that was one of the reasons they have discovered they have physical problems later in life» ---- We have been married for 51 years, and have never been without two labs at one time (a dog needs a dog companion, the same as humans) when we lose one, we all mourn her loss, so we get her a puppy and we start another member of our family.

The Atlantic Palolo Worm, Eunice schemacephala, is a larger form that spawns at times related to the lunar cycles.

You will need the full amount of cash to pay off the bill within the billing cycle, so this isn't the card for you if you're looking to make a large purchase and spend some time paying it off.

I spent a significant amount of my time on Everything rolling as an avalanche of large boulders across the unending grassy hills of a green continent, simply because I could — you're given the ability to become any of your previously encountered things, at any phase in the ascent / descent cycle, so the possibilities are endless and highly entertaining.

Two game modes — test your world - building skills in timed cycles of creation and destruction under Ragnarosa and Fortuna's vigilant watch, or take your time and build up a world as large as you can at your own pace, under the calming influence of Serenity.

Defeating large bosses turns back the moon's cycle and gives you more time to operate.

Shown alongside five new large - scale collage works on paper that use gold leaf, cuttings from the Financial Times, batik fabric flowers and luxury magazine covers, Shonibare's reflection on the Hong Kong economy and its desire for luxury goods is a poignant reminder of the cycle of contradictions surrounding wealth and power, poverty and danger; dare to dream rich and you may lose your head, fail to dream rich and risk dying of poverty.

A period for which the SCL index is NOT «well defined», and an area many times larger than the Greenland Sea, behaving in a fashion for which we have no recent precedent according to literature — see, for instance the review article from Polyak et al, 2010 — «could» be natural since a possible relationship between sea ice and solar cycle length has been demonstrated, sort of.

Second, sub-stage 19c lies near the middle - Pleistocene, a time when the climate system appears to have been most clearly transitioning from smaller amplitude, shorter period, and more symmetric glacial cycles, to the larger, longer, and more saw - toothed glacial cycles of the late Pleistocene.

, but a suggestion for avoiding coupling shock: take a large number of model runs; for each assign a location in some n - space for indices of the more important modes of (internal) variability (but maybe also include indices for timing relative to and magnitude of eruptions, solar cycles, etc.).

This leaves the solar cycle the only known cause of climate change on large scale, up to modern times where there is a documented antropogenic contribution.

Several studies claim that on average the earth the solar cycle has amplitude of approximately 0.1 K. (Three times larger than what present models predict).

3 claims that the GHG human emission rate is approximately 2 times larger than the observed rate during the last decades, so if the Sun drives a little bit the CO2 and CH4 cycle mechanisms (which in this case are absorbing large amount of CO2 and CH4 from the atmosphere) it might leave a signal in the CO2 and CH4 record as well.

The change in insolation due to orbital changes are significant, of the order of 50 W / m2, or 50 times larger than the change of TSI over the solar cycle.

The better way of looking at the issue is to take as the starting point a stationary carbon cycle where large volumes of carbon are moving around all the time and consider the human contribution as a disturbance to this system.

We see this on shorter timescales in glacial cycles and the second great field geology rule is that small things and short time mimics large things and long time.

Lui - 2011 Fig. 2 Power Spectrum shows large power density at frequencies below 0.05 / yr (i.e. cycle times > = 20 years).