Sentences with phrase «lasting synaptic plasticity»

In addition to fragile X syndrome, my laboratory also has conducted studies to determine whether the signaling cascades that normally are required for long - lasting synaptic plasticity and memory are altered in mouse models of several developmental disorders, iincluding autism spectrum disorder (ASD), intellectual disability (ID), tuberous sclerosis complex (TSC), and Angelman syndrome.

We continue to focus our efforts on understanding the distinct roles of the various types of translational control in long - lasting synaptic plasticity and memory using pharmacological and genetic approaches in various brain regions, including the hippocampus, amygdala, and prefrontal cortex.

Detailed biochemical and sophisticated imaging experiments are employed to delineate the molecular signaling cascades that couple receptors to the translational apparatus during long - lasting synaptic plasticity in the hippocampus, amygdala, cortex, and striatum, and whether these types of translational control are required for memory formation, social behaviors, and behavioral flexibility.

It has been known for decades that triggering new protein synthesis is vital to the formation of long - term memories as well as for long - lasting synaptic plasticity — the ability of the neurons to change the collective strength of their connections with other neurons.

Moreover, in conjunction with these results, they found decreased protein synthesis, known to be required for long - term potentiation — a form of long - lasting synaptic plasticity — and for long - term memory.

Molecular studies of gene expression during long - lasting synaptic plasticity related to memory storage initially focused on the identification of positive regulators.

More recent work has revealed that the establishment of long - lasting synaptic plasticity and long - term memory also requires the removal of inhibitory constraints.

Not exact matches

The heightened potential for synaptic plasticity was temporary, lasting between a week and a month after ethanol injections stopped, according to the researchers.

It has been known for many years that long - lasting forms of synaptic plasticity and long - term memory require new protein synthesis.