This relatively
late age of diagnosis is a reminder of how important it is to be aware of milestones that mark a child's development and to act early if a delay is suspected.
For people with celiac disease,
the later the age of diagnosis, the greater the chance of developing another autoimmune disorder.
In a 1999 study, Ventura, et al. found that for people with celiac disease,
the later the age of diagnosis, the greater the chance of developing another autoimmune disorder.
Not exact matches
The state (SCDDSN) agreed that any child who was deemed «presumptively eligible» for ABA through BabyNet and
later received a
diagnosis of ASD would continue to receive ABA therapy after reaching
age three under the Medicaid waiver or through the special state appropriations.
Mucosal melanoma tends to develop
later in life compared with cutaneous melanoma, with a median
age at
diagnosis of 70 vs 55 years.
Overall, researchers showed that regardless
of other risk factors, including
age at
diagnosis or the initial white blood cell count, patients with an MRD level
of 1 percent or more on day 19
of therapy were far less likely than other young leukemia patients to be alive and cancer - free 10 years
later.
The mean
age at
diagnosis was 6.2 ± 3.1 years but changes were seen as early as 1.1 and as
late as 12.6 years
of age.
As a result, they tend to spend more time onlooking (watching other children without joining) and hovering on the edge
of social groups.8, 11 There is some evidence to suggest that young depressive children also experience social impairment.12 For example, children who display greater depressive symptoms are more likely to be rejected by peers.10 Moreover, deficits in social skills (e.g., social participation, leadership) and peer victimization predict depressive symptoms in childhood.13, 14 There is also substantial longitudinal evidence linking social withdrawal in childhood with the
later development
of more significant internalizing problems.15, 16,17 For example, Katz and colleagues18 followed over 700 children from early childhood to young adulthood and described a pathway linking social withdrawal at
age 5 years — to social difficulties with peers at
age 15 years — to
diagnoses of depression at
age 20 years.
Given their typical
age of onset, a broad range
of mental disorders are increasingly being understood as the result
of aberrations
of developmental processes that normally occur in the adolescent brain.4 — 6 Executive functioning, and its neurobiological substrate, the prefrontal cortex, matures during adolescence.5 The relatively
late maturation
of executive functioning is adaptive in most cases, underpinning characteristic adolescent behaviours such as social interaction, risk taking and sensation seeking which promote successful adult development and independence.6 However, in some cases it appears that the delayed maturation
of prefrontal regulatory regions leads to the development
of mental illness, with neurobiological studies indicating a broad deficit in executive functioning which precedes and underpins a range
of psychopathology.7 A recent meta - analysis
of neuroimaging studies focusing on a range
of psychotic and non-psychotic mental illnesses found that grey matter loss in the dorsal anterior cingulate, and left and right insula, was common across
diagnoses.8 In a healthy sample, this study also demonstrated that lower grey matter in these regions was found to be associated with deficits in executive functioning performance.
Weighted - average correlation coefficients between equivalent pairs
of SDQ and Child Behavior Checklist subscales11 from 9 parent - reported studies were uniformly strong and positive (range: 0.52 < r < 0.71).10 Several studies showed strong correlations between SDQ subscales and «real world» outcomes such as clinical
diagnoses (criterion validity); SDQ scores identified school -
aged children with concurrent behavioral and emotional disorders, including attention - deficit / hyperactivity disorder (ADHD) and autism spectrum disorder / Asperger syndrome (ASD / AS), and predicted their occurrence 3 years
later.4, 12,13 However, multitrait - multimethod analyses have not provided consistently strong evidence
of discriminant validity
of the school -
age SDQ subscales.
Deaf children whose hearing losses were diagnosed by 6 months
of age and provided early intervention shortly after
diagnosis showed typical development
of language abilities as compared to those who were diagnosed
later and subsequently, if at all, provided early intervention services (Yoshinaga - Itano, Sedey, Coulter, & Mehl, 1998).
Finally, we used criterion outcome measures at
age 5, which included parent - reported
diagnoses of ADHD and ASD / AS and teacher - reported measures
of personal, social, and emotional (PSE) development to assess the utility
of the preschool SDQ to predict clinical outcomes 2 years
later.