Sentences with phrase «late stage changes»

Not exact matches

His intention to change Obamacare at this late stage could also have far - reaching impacts.

And it doesn't change the fact that our late - stage venture markets are over-valued relative to public markets, so either

It should be no surprise that many countries in the late stages of their own investment - growth «miracles» have tried this kind of transformation, but none has ever managed so radical a change within its financial sector quickly enough, at least in part because the capital allocation decision is at the heart of distributional politics.

The late - stage venture capital business is forever changed by what Softbank is doing.

It'd be too much work to change a 10 - page cover story at a really late stage in the game.

It seems probable that the metabolic and endocrine changes observed in the later stages of alcoholism may play an important part in the perpetuation of the addiction.

These two claims are based on the defining assumption of Ford's genetic approach: that Whitehead's metaphysical thought changed almost constantly from the time he came to Harvard in 1924 until it finally crystallized, in late 1928, during the last stages of preparing for publication his Gifford Lectures.

Late stage customisation enhances marketing capabilities and also allows manufacturers to be more flexible with decision - making on site, whether it involves changing «best before» dates and production data or adding in promotional codes that can be used for interacting with customers, raising brand loyalty and running sales campaigns.

Maintain our good relationship with them, get a nice chunk of change for a 29 year old defender, Toby gets his payday, a guaranteed league title (or at least more likely than at Spurs) and probably late stages CL (although it is PSG), everyone wins

Rather, she praises him for his willingness to change his game at this late stage.

Robbie Brady's late header sent Republic of Ireland into the knockout stages of the European Championship for the first time after a 1 - 0 win over a much - changed Italy side in Lille.

Robbie Brady's late header sent the Republic of Ireland into the knockout stages of the European Championship for the first time after a 1 - 0 win over a much - changed Italy side in Lille.

Pura Kiki features a unique design allowing parents to use the bottle with a nipple for your baby's early stage and bottle feeding needs then later on, you can change the nipple into a sip or a straw.

• No contact at one stage does not necessarily predict no - contact at a later stage: Maclean & Eekelaar (1997) found non-resident fathers changing the nature and extent of their contact with their children over time, with many drifting back into contact after initial separation.

The early stages of labour when you are confident you will be able to breathe your way through the pain of labour and will have no need for any drugs, this can change later on!

Estimates of the numbers of women booked for home birth but delivering in hospital were even more difficult to obtain because hospital records do not always specify this information accurately and no national estimate exists.1 4 Data collected in this region in 1983 suggested that 35 % of these women changed to hospital based care either before or during labour, and a more detailed prospective study of all planned home births in 1993 found a total transfer rate of 43 %.8 Women were classified as having booked for a home birth when a community midwife had accepted a woman for home delivery and had this arrangement accepted by her manager and supervisor of midwives at any stage in pregnancy, irrespective of any later change of plan.

Any amount of caffeine can also cause changes in your baby's sleep pattern or normal movement pattern in the later stages of pregnancy.

During the late stages of pregnancy the milk will change to colostrum, and some older nurslings will continue to feed even with this change, while others may wean due to the change in taste or drop in supply.

«What can we do to ensure that, if the leave campaign looks to be gaining momentum at a late stage, that will not be used to pretend that there are things on the meeting's agenda to try to change people's opinions, or that things will not be leaked in advance of that meeting to try to give people the impression that the Government have agreed a better deal than is actually the case?»

We do appreciate that it is not ideal to be changing our approach at this late stage.

A compromise deal would therefore have to include provisions that Britain «pay [s] our fair share of the costs of enlargement», the budget be reduced, and a mid-term review be set up to allow for changes at a later stage.

The rationale seems to be that with the narrowest of wins in sight, a late - stage leadership change would be an unnecessary risk.

It is only fair and reasonable that any changes proposed at this late stage meet those high standards.

Most research has focused on understanding and managing the late consequences of sepsis while little is known about the changes occurring in the bone marrow at early stages of the response to bacterial infection, when the opportunity for effective treatment might still be available.

To better understand what metabolic changes occur in place of fatty acid - burning, Kelly's team studied well established mouse models of the early and late stages of heart failure.

Professor Sinclair said: «It is well established that prior to conception and in the early stages of pregnancy during natural or assisted reproduction subtle chemical changes can affect the human genome leading to development and late - onset chronic diseases.

The researchers concluded that in the early stages after stroke, improvements in voluntary movement can be attributed to a reduction in brain swelling because of the trauma and other spontaneous repairs, while later improvements result from «neuronal plasticity» — the reorganization or regeneration of nerve cells within the spinal cord in response to changes in the nerve network.

That doesn't mean women are intentionally changing their sexual orientation, but for various reasons, such change is often happening later in women's lives and may actually change back - and - forth multiple times during different life stages throughout a woman's lifetime.

Changes in the manipulation medium, as well as a move from late to early stages after first appearance of pronuclei, produced blastocysts which were statistically indistinguishable from those produced in normal IVF by measures of morphology, ploidy and gene expression.

This gas was enriched in the heavy elements (i.e., elements heavier than helium) produced in stars during the later stages of their evolution, so that the interstellar gas in the Galaxy is continually being changed.

The progression of melanoma from early to late stage involves a series of signaling changes within the cell, often described in terms of «pathways.»

«Basic scientific research supported by the Department of Energy is crucial to providing the foundation for innovative technologies and later - stage research to reduce carbon emissions and combat climate change,» said Under Secretary for Science and Energy Lynn Orr.

When my mom was diagnosed with late - stage endometrial cancer and had to make some changes to her predominantly plant - based diet, I was also forced to reckon with the veracity of my own beliefs.

When pregnant rats were given low does of 2 mg / kg / day via their diet it the late stages of gestation and through the end of lactation, their offspring had «decreased male anogenital distance and retention of nipples, reduction of testicular spermatocyte development as well as mammary glad changes at low incidence in both sexes.»

For people who are in the later stage of burnout, changing the underlying cause may not be enough.

Conversely, within non-diabetic populations, periods of IER (75 - 85 % ER on restricted days) do not typically affect fasting glucose levels 37, 41, 45, 48 or HbA1c 41, 48; results of which can often be replicated by short term CER studies.62 - 65These findings are unsurprising given that frank hyperglycaemia within the T2DM diagnostic range is effectively a late - stage manifestation of IR, which along with compensatory increases insulin secretion, can precede the onset of T2DM by many years.66, 67 Findings from one large scale prospective cohort study, Whitehall II, reveal a sharp increase in the trajectory towards fasting hyperglycaemia which is only detectable three years prior to diagnosis with T2DM.67 Consequently, it can be argued that changes in circulating insulin concentrations, fasting (hepatic) insulin sensitivity and glucose uptake / clearance are more sensitive markers of deteriorating glucose control than fasting glycaemia in non - diabetics.68 - 70

Early - life stressors are known to induce changes in gene expression that set the stage for disease in later life.30 Thus, unfortunately, exposure to mercury in either parent, even prior to conception, can affect the child's own genetic expression.

Maybe it just changes the profile of growth hormone release so that even though you don't have as much of a peak in the first sleep cycle, maybe you have more growth hormone released at later stages.

Perhaps the most striking thing about Dishonored is the way the later stages of the game change, depending on how you've approached earlier missions.

In addition to this, later stages are notable for restricting or removing certain abilities of Kagemaru, simultaneously raising the difficulty and forcing players to change tactics.

Worse yet, a late - stage costume change conjures specific memories of an iconic Myers identity, inspiring titters rather than the tingles I assume Stein had hoped for.

For contemporary cinephiles, The Last Metro sets the stage for Deneuve and Depardieu's reunion twenty - four years later in André Téchiné's Changing Times, another politically revisionist romance.

«I later helped other schools with how they could apply a similar methodology, so they were modelling change in the early stages, rather being in the situation I was in.»

A puncture and a small navigation error, together with a reduction in speed in the later part of the stage, to prevent damage to the car's steering, did not change the pair's overall race classification of sixth place.

Changing your pen name at a later stage of your career, especially if it means to republish your books under a different author name is painful.

This is not only exciting but allows the author complete control so that they can change anything about the way their book looks and feels even at this late stage.

The processor is an octa - core unit clocked at 1.9 GHz — based on what we know so far, this could be the Exynos 5433 but could change to an Exynos 7420 at a later stage to take advantage of Android 5.0's support for 64 - bit processing.

Adobe has announced that its latest update to the Flash runtime in 10.2 will be included with the RIM PlayBook tablet as well as Android 3.0, with the bulk of the changes centering around its new Stage Video hardware acceleration for Flash video in order to reduce processor and memory demands.

Your employees may find it helpful to have access to these options if they want to change their investment mix at a later stage.

Your Income needs will probably change during retirement so we've ensured our pension offers the options you may require, from the flexibility of a drawdown pension in the early stages of retirement, to effective estate planning later.